Intracoronary Injection of Nicorandil Alleviates No-Reflow in Elderly Patients with Acute STEMI Undergoing Emergency PCI

doi:10.3923/ijp.2024.956.963

科研成果详情

题名	Intracoronary Injection of Nicorandil Alleviates No-Reflow in Elderly Patients with Acute STEMI Undergoing Emergency PCI
作者	Liu, Senfeng 1; Lin, Lili 2; Chen, Yuehong 1; Dong, Honglin 1; Xie, Shuyuan 1; Wang, Wei3; Huang, Yuxuan 1; Qiu, Yuanjie 1
发表日期	2024
发表期刊	INTERNATIONAL JOURNAL OF PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Nicorandil intracoronary injection no-reflow acute ST-segment elevation myocardial infarction percutaneous coronary intervention prognosis
其他关键词	ACUTE MYOCARDIAL-INFARCTION ; PERCUTANEOUS CORONARY INTERVENTION ; SHORT-TERM PROGNOSIS
摘要	Background and Objective: The incidence of slow or no reflow during emergency percutaneous coronary intervention (PCI) is as high as 10-30%. How to prevent or alleviate no-reflow and improve myocardial perfusion during PCI has become a crucial clinical issue. To evaluate the impact of intracoronary injection of nicorandil on the no-reflow phenomenon in elderly patients with acute ST-segment Elevation Myocardial Infarction (STEMI) undergoing emergency PCI. Materials and Methods: The clinical data of 200 elderly patients with STEMI exhibiting the no-reflow phenomenon during emergency PCI at The First Affiliated Hospital of Wenzhou Medical University from August, 2016 to December, 2018 were retrospectively analyzed. According to the different treatment methods, they were divided into control group (n = 86) for intracoronary injection of nitroglycerin and study (n = 114) group for intracoronary injection of nicorandil. The two groups were compared in terms of the following indexes: Thrombolysis in Myocardial Infarction (TIMI) flow grade, echocardiographic parameters, serum markers, hemodynamic parameters and major adverse cardiovascular events (MACE). Results: After injection, the study group had higher TIMI flow grade; higher left ventricular ejection fraction, antithrombin III and tissue plasminogen activator; higher E/A ratio; higher cardiac index; lower left atrium volume index, global end-diastolic index and systemic vascular resistance index; lower von Willebrand factor, creatine kinase-MB fraction, cardiac troponin I, N-terminal pro-brain natriuretic peptide, cardiac troponin T and fibrinogen and lower MACE rates than the control group (p<0.05). Conclusion: Intracoronary injection of nicorandil can effectively improve the no-reflow phenomenon and facilitate the prognosis of elderly patients with STEMI undergoing emergency PCI.
出版者	ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET
ISSN	1811-7775
EISSN	1812-5700
卷号	20 期号:6
DOI	10.3923/ijp.2024.956.963
页数	9
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001337978400005
收录类别	SCIE
通讯作者地址	[Liu, Senfeng]Xiamen Huaxia Univ, Xiamen 361024, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220688
专题	附属第一医院附属第一医院_神经外科
通讯作者	Liu, Senfeng
作者单位	1.Xiamen Huaxia Univ, Xiamen 361024, Peoples R China; 2.Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang 43400, Malaysia; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurosurg, Wenzhou 325000, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Liu, Senfeng,Lin, Lili,Chen, Yuehong,et al. Intracoronary Injection of Nicorandil Alleviates No-Reflow in Elderly Patients with Acute STEMI Undergoing Emergency PCI[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY,2024,20(6).
APA	Liu, Senfeng., Lin, Lili., Chen, Yuehong., Dong, Honglin., Xie, Shuyuan., ... & Qiu, Yuanjie. (2024). Intracoronary Injection of Nicorandil Alleviates No-Reflow in Elderly Patients with Acute STEMI Undergoing Emergency PCI. INTERNATIONAL JOURNAL OF PHARMACOLOGY, 20(6).
MLA	Liu, Senfeng,et al."Intracoronary Injection of Nicorandil Alleviates No-Reflow in Elderly Patients with Acute STEMI Undergoing Emergency PCI".INTERNATIONAL JOURNAL OF PHARMACOLOGY 20.6(2024).