HIF-1α induced FGF18 alleviates renal ischemia/reperfusion injury via YAP

doi:10.1096/fj.202401238R

科研成果详情

题名	HIF-1α induced FGF18 alleviates renal ischemia/reperfusion injury via YAP
作者	Wang, Nan1,2; Huang, Zhiyuan3; Guan, Fangqian1; Wang, Jiaqi1; Chen, Yinyun 1; Wang, Hong 4; Jin, Litai1; Wang, Yang 4
发表日期	2024-10-15
发表期刊	FASEB Journal 影响因子和分区
语种	英语
原始文献类型	Article
关键词	acute kidney injury fibroblast growth factor 18 HIF-1 alpha ischemia/reperfusion YAP
其他关键词	CELL-CYCLE ARREST ; KIDNEY INJURY ; HIPPO PATHWAY ; PROLIFERATION ; APOPTOSIS
摘要	Acute kidney injury (AKI) is a devastating clinical condition characterized by an abrupt loss of renal function. The pathophysiology of AKI involves diverse processes and elements, of which survival and regeneration have been established to be significant hallmarks. And early studies have confirmed the fundamental role of FGFs in the regulation of AKI pathology, although the association between FGF18 and AKI still remains elusive. Our study demonstrates a substantial up-regulation of FGF18 in the renal tubules of mice subjected to ischemia. Notably, targeted overexpression of FGF18 effectively mitigates the impairment of kidney function induced by AKI. Mechanistically, FGF18 facilitates cell proliferation and anti-apoptosis in RTECs by enhancing the expression of YAP and facilitating its translocation to the nucleus. Aside from that, we also discovered that the substantial expression of FGF18 under ischemic conditions is HIF-1 alpha dependent. This study aims to uncover the inherent mechanism behind the beneficial effects of FGF18 in attenuating AKI. By doing so, it aims to offer novel insights into the development of therapeutic strategies for AKI.
资助项目	MOST \| National Natural Science Foundation of China (NSFC) [82273560]; National Natural Science Foundation of China [LZ21H020002]; Zhejiang Provincial Natural Science Foundation
出版者	WILEY
ISSN	0892-6638
EISSN	1530-6860
卷号	38 期号:19
DOI	10.1096/fj.202401238R
页数	15
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS记录号	WOS:001330225600001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39373977
SCOPUSEID	2-s2.0-85205815381
通讯作者地址	[Jin, Litai]Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China. ; [Wang, Yang]Wenzhou Med Univ, Sch Basic Med Sci, Wenzhou, Peoples R China.
Scopus学科分类	Biotechnology;Biochemistry;Molecular Biology;Genetics
SCOPUS_ID	SCOPUS_ID:85205815381
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220677
专题	药学院（分析测试中心）基础医学院（机能实验教学中心）附属台州医院其他_附属台州医院（浙江省台州医院）
通讯作者	Jin, Litai; Wang, Yang
作者单位	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China; 2.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Peoples Hosp, Dept Pharm, Hangzhou, Peoples R China; 3.Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Linhai, Peoples R China; 4.Wenzhou Med Univ, Sch Basic Med Sci, Wenzhou, Peoples R China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）; 基础医学院（机能实验教学中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Wang, Nan,Huang, Zhiyuan,Guan, Fangqian,et al. HIF-1α induced FGF18 alleviates renal ischemia/reperfusion injury via YAP[J]. FASEB Journal,2024,38(19).
APA	Wang, Nan., Huang, Zhiyuan., Guan, Fangqian., Wang, Jiaqi., Chen, Yinyun., ... & Wang, Yang. (2024). HIF-1α induced FGF18 alleviates renal ischemia/reperfusion injury via YAP. FASEB Journal, 38(19).
MLA	Wang, Nan,et al."HIF-1α induced FGF18 alleviates renal ischemia/reperfusion injury via YAP".FASEB Journal 38.19(2024).