Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study

doi:10.3389/fgene.2024.1335839

科研成果详情

题名	Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study
作者	Xie, Weidong1; Jiang, Haojie1; Chen, Yao 2; Yu, Zhaojie 3; Song, Yaoyu 3; Zhang, Huanhao 4; Li, Sen5; Han, Shaoliang1; Liu, Naxin1
发表日期	2024-09-16
发表期刊	FRONTIERS IN GENETICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	systemic lupus erythematosus (SLE) rheumatoid arthritis (RA) inflammatory bowel disease (IBD) type 1 diabetes(T1D) Mendelian randomization(MR)
其他关键词	INFLAMMATORY-BOWEL-DISEASE ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; GENETIC SUSCEPTIBILITY ; RHEUMATOID-ARTHRITIS ; ASSOCIATION ; EPIDEMIOLOGY ; MELLITUS ; RISK ; INSTRUMENTS ; LOCI
摘要	Background: Previous studies have suggested an association between Type 1 diabetes (T1D) and autoimmune diseases (AIDs), but the causal relationship remains unclear. Therefore, this study utilizes publicly available Genome-Wide Association Studies (GWAS) databases and employs a two-sample Mendelian Randomization (MR) approach to explore the causal relationships between T1D and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). Methods: Summary GWAS data for T1D, SLE, RA, and IBD were downloaded from open GWAS databases and the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). We employed a series of methods to select instrumental variables closely related to T1D. To enhance the reliability of our conclusions, we applied multiple robust analytical methods, with the inverse variance weighted (IVW) method as the primary approach. Validation and meta-analysis were conducted using the FinnGen consortium. Additionally, we assessed heterogeneity, pleiotropy, and sensitivity to ensure the robustness of our conclusions. Results: A potential causal association was found between T1D and SLE (OR = 1.37, 95% CI = 1.26 - 1.49, P < 0.001), which was further confirmed by meta-analysis. Similarly, a potential causal association was found between T1D and RA (OR = 1.32, 95% CI = 1.17 - 1.50, P < 0.001), and this was also confirmed by meta-analysis. Although the association between T1D and IBD showed P < 0.05, the leave-one-out test did not pass, and further meta-analysis indicated no significant statistical association between them. Conclusion: Our study reveals the relationships between T1D and three clinically common autoimmune diseases (SLE, RA, and IBD). This research supplements previous studies and provides a reference for future clinical work.
资助项目	Zhejiang Medical and Health Project (Key Talents) [2014RCA014]; Wenzhou Municipal Science and Bureau [Y20210184]; Zhejiang Provincial Health Department Medical Support Discipline-Nutrition [11-ZC24]; Natural Science Foundation of Zhejiang Province [LQ20H020002]; General Research Project of Zhejiang Provincial Department of Education [Y201942047]; Wenzhou Science and Technology Program [Y20180060]
出版者	FRONTIERS MEDIA SA
EISSN	1664-8021
卷号	15
DOI	10.3389/fgene.2024.1335839
页数	9
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:001322796100001
收录类别	SCIE
PubMed ID	39350769
通讯作者地址	[Han, Shaoliang;Liu, Naxin]Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Wenzhou, Peoples R China. ; [Li, Sen]Wenzhou Med Univ, Sch Basic Med, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220676
专题	附属第一医院基础医学院（机能实验教学中心）公共卫生学院第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_胃肠外科
通讯作者	Li, Sen; Han, Shaoliang; Liu, Naxin
作者单位	1.Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Wenzhou, Peoples R China; 2.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Grad Sch,Dept Med Oncol, Hangzhou, Peoples R China; 3.Wenzhou Med Univ, Sch Med 1, Sch Informat & Engn, Wenzhou, Peoples R China; 4.Wenzhou Med Univ, Sch Publ Hlth & Management, Wenzhou, Peoples R China; 5.Wenzhou Med Univ, Sch Basic Med, Wenzhou, Peoples R China
第一作者单位	附属第一医院; 胃肠外科
通讯作者单位	附属第一医院; 胃肠外科; 基础医学院（机能实验教学中心）
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xie, Weidong,Jiang, Haojie,Chen, Yao,et al. Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study[J]. FRONTIERS IN GENETICS,2024,15.
APA	Xie, Weidong., Jiang, Haojie., Chen, Yao., Yu, Zhaojie., Song, Yaoyu., ... & Liu, Naxin. (2024). Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study. FRONTIERS IN GENETICS, 15.
MLA	Xie, Weidong,et al."Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study".FRONTIERS IN GENETICS 15(2024).