Aptamer-conjugated dendrimer-modified quantum dots for glioblastoma cells imaging

doi:10.1088/1742-6596/188/1/012032

科研成果详情

题名	Aptamer-conjugated dendrimer-modified quantum dots for glioblastoma cells imaging
作者	Li, Zhiming1,2,3,4; Huang, Peng 2; He, Rong 2; Zhang, Xiaomin 1; Bao, Chenchen 2; Ren, Qiushi 1; Cui, Daxiang 2
会议录名称	8TH CHINA INTERNATIONAL NANOSCIENCE AND TECHNOLOGY SYMPOSIUM (CINSTS09) 影响因子和分区
语种	英语
原始文献类型	Proceedings Paper
会议名称	8th China International Nanoscience and Technology Symposium (Cinsts 09)
会议日期	OCT 23-27, 2009
会议地点	Xiangtan, PEOPLES R CHINA
摘要	Targeted quantum dots have shown potential as a platform for development of cancer imaging. Aptamers have recently been demonstrated as ideal candidates for molecular targeting applications. In present work, polyamidoamine dendrimers were used to modify surface of quantum dots and improve their solubility in water solution. Then, dendrimer-modified quantum dots were conjugated with DNA aptamer, GBI-10, can recognize the extracellular matrix protein tenascin-C on the surface of human glioblastoma cells. The dendrimer-modified quantum dots exhibit water-soluble, high quantum yield, and good biocompatibility. Aptamer-conjugated quantum dots can specifically target U251 human glioblastoma cells. High-performance aptamer-conjugated dendrimers modified quantum dot-based nanoprobes have great potential in application such as cancer imaging.
资助项目	China National 973 ProjectNational Basic Research Program of China [2005CB723400-G]; China National 863 Project [2005AA001070, 2007AA022004]; National Natural Scientific Fund [20471599, 30672147]; Shanghai Scientific Fund [0752nm24]; Wenzhou Fund of Science and Technology [20070034, 07211206]
出版地	BRISTOL
出版者	IOP PUBLISHING LTD
ISSN	1742-6588
EISSN	1742-6596
卷号	188
DOI	10.1088/1742-6596/188/1/012032
页数	4
URL	查看原文
WOS类目	Nanoscience & Nanotechnology
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000280341500032
收录类别	CPCI ; SCOPUS
发表日期	2009-12-31
通讯作者地址	[Ren, Qiushi]Institute for Laser Medicine and Biophotonics,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,China
Scopus记录号	2-s2.0-73349101532
Scopus学科分类	Physics and Astronomy (all)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/22065
专题	附属第一医院_皮肤科第一临床医学院（信息与工程学院）、附属第一医院_皮肤病与性病学
通讯作者	Ren, Qiushi
作者单位	1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Inst Laser Med & Biophoton, Shanghai 200240, Peoples R China; 2.Shanghai Jiao Tong Univ, Inst Micro Nano Sci & Technol, Natl Key Lab Nano Micro Fabricat Technol, Key Lab Thin Film & Microfabricat,Minist Educ, Shanghai 200240, Peoples R China; 3.Wenzhou Med Coll, Dept Dermatol Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China; 4.Wenzhou Med Coll, Inst Dermatol, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	皮肤科; 皮肤病与性病学
推荐引用方式 GB/T 7714	Li, Zhiming,Huang, Peng,He, Rong,et al. Aptamer-conjugated dendrimer-modified quantum dots for glioblastoma cells imaging[C]. BRISTOL:IOP PUBLISHING LTD,2009.