Ferric Iron/Shikonin Nanoparticle-Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes

doi:10.1002/advs.202405463

科研成果详情

题名	Ferric Iron/Shikonin Nanoparticle-Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes
作者	Chen, Xiaojing 1; Li, Zhangping 2; Ge, Xinxin3; Qi, Xiaoliang4; Xiang, Yajing 3; Shi, Yizuo3; Li, Ying 5; Pan, Yao 1; Wang, Yingying 1; Ru, Yiyu1; Huang, Kelei 1; Shao, Jiatan 1; Shen, Jianliang4,5; Li, He1
发表日期	2024-10-11
发表期刊	ADVANCED SCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	diabetes hydrogels oral ulcers shikonin, tissue adhesives
其他关键词	SCAFFOLDS
摘要	Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due to poor adherence, short retention time in the mouth, and less-than-optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made of a silk fibroin/hyaluronic acid matrix with light-sensitive adhesive qualities infused with ferric iron/shikonin nanoparticles to enhance healing effects is presented. Initially, this hydrogel forms an adhesive barrier over mucosal lesions through a straightforward local injection, solidifying when exposed to UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination and near-infrared photothermal bactericidal activity. These characteristics support bacterial elimination and regulate oxidative levels, promoting a wound's progression from inflammation to tissue regeneration. In a diabetic rat model mimicking oral ulcers, FSH3 significantly speeds up healing by adjusting the inflammatory environment of the injured tissue, maintaining balance in oral microbiota, and promoting faster re-epithelialization. Overall, the light-sensitive FSH3 hydrogel shows potential for rapid wound recovery and may transform therapeutic methods for managing oral ulcers in diabetes. A novel light-responsive hydrogel (FSH3) is crafted for treating diabetic oral ulcers. Upon application at the affected area, FSH3 binds robustly, delivering outstanding performance in eliminating reactive oxygen species and providing near-infrared photothermal bactericidal effects. It successfully eradicates bacteria and adjusts the oxidative environment to enhance wound healing. image
资助项目	Zhejiang Provincial Natural Science Foundation of China; Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar [LR23C100001]; National Natural Science Foundation of China [82171144, 21977081, 82372551]; Competitive Research Project of Quzhou Science &Technology Bureau [2022K47]; Wenzhou Basic Public Welfare Research Project [Y20220085]; [LQ22E030011]
出版者	WILEY
ISSN	2198-3844
EISSN	2198-3844
DOI	10.1002/advs.202405463
页数	20
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001329982500001
收录类别	SCIE ; EI ; PUBMED
EI入藏号	20244117182611
EI主题词	Tissue regeneration
EI分类号	101.1 ; 102.2.1 ; 801.1 Chemistry, General ; 801.2 Biochemistry ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	39392368
通讯作者地址	[Li, He]Wenzhou Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Wenzhou 325000, Zhejiang, Peoples R China. ; [Qi, Xiaoliang;Shen, Jianliang]Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Zhejiang, Peoples R China. ; [Shen, Jianliang]Univ Chinese Acad Sci, Wenzhou Inst, Zhejiang Engn Res Ctr Tissue Repair Mat, Wenzhou 325001, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220659
专题	附属第一医院附属第一医院_耳鼻咽喉科眼视光学院（生物医学工程学院）、附属眼视光医院口腔医学院、附属口腔医院其他_温州医科大学附属衢州医院
通讯作者	Qi, Xiaoliang; Shen, Jianliang; Li, He
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Quzhou Affiliated Hosp, Quzhou Peoples Hosp, Quzhou 324000, Peoples R China; 3.Wenzhou Med Univ, Sch & Hosp Stomatol, Wenzhou 325027, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Zhejiang, Peoples R China; 5.Univ Chinese Acad Sci, Wenzhou Inst, Zhejiang Engn Res Ctr Tissue Repair Mat, Wenzhou 325001, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 耳鼻咽喉科
通讯作者单位	附属第一医院; 耳鼻咽喉科; 眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Xiaojing,Li, Zhangping,Ge, Xinxin,et al. Ferric Iron/Shikonin Nanoparticle-Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes[J]. ADVANCED SCIENCE,2024.
APA	Chen, Xiaojing., Li, Zhangping., Ge, Xinxin., Qi, Xiaoliang., Xiang, Yajing., ... & Li, He. (2024). Ferric Iron/Shikonin Nanoparticle-Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes. ADVANCED SCIENCE.
MLA	Chen, Xiaojing,et al."Ferric Iron/Shikonin Nanoparticle-Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes".ADVANCED SCIENCE (2024).