In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegradable bone-implant applications

doi:10.1016/j.bioactmat.2024.09.026

科研成果详情

题名	In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegradable bone-implant applications
作者	Tong, Xian1,2; Shen, Xinkun3; Lin, Zhiqiang1; Zhou, Runqi 4; Han, Yue1; Zhu, Li 1; Huang, Shengbin1; Ma, Jianfeng1; Li, Yuncang 5; Wen, Cuie 5; Lin, Jixing1
发表日期	2025-01
发表期刊	Bioactive Materials 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Biodegradability Biotribological performance Mechanical property Osteogenesis Mg 2 Ge/Zn composite
其他关键词	CORROSION BEHAVIOR ; BINARY-ALLOYS ; ZINC-ALLOYS ; ZN ; MICROSTRUCTURE ; MG ; ANTIBACTERIAL ; DEFORMATION ; METALS ; CYTOCOMPATIBILITY
摘要	Zinc (Zn)-based composites are promising biodegradable bone-implant materials because of their good biocompatibility, processability, and biodegradability. Nevertheless, the low interfacial bonding strength, coordinated deformation capacity, and mechanical strength of current Zn-based composites hinder their clinical application. In this study, we developed a biodegradable in situ 4Mg2Ge/Zn-0.3Cu-0.05P composite (denoted ZMGCP) via phosphorus (P) modification and hot-rolling for bone-implant applications. The mechanical properties, corrosion behavior, biotribological performance, in vitro cytocompatibility and osteogenic differentiation, and in vivo osteogenesis and osteointegration of the as-cast (AC) and hot-rolled (HR) ZMGCP samples were systematically evaluated and compared to those of 4Mg2Ge/Zn-0.3Cu (denoted ZMGC). The primary and eutectic reinforcement Mg2Ge phases formed during solidification were refined after P modification and hot-rolling. The HR ZMGCP exhibited the best tensile properties among all the samples with an ultimate tensile strength of 288.9 MPa, a yield strength of 194.5 MPa, and an elongation of 17.7 %. The HR ZMGCP showed the lowest corrosion rate of 336 mu m/a, 186 mu m/a, and 61.7 mu m/a as measured by potentiodynamic polarization, electrochemical impedance spectroscopy, and immersion testing, respectively, among all the samples in Hanks' solution. The HR ZMGCP also showed higher biotribological resistance than its ZMGC counterpart. The HR ZMGCP exhibited the highest in vitro cytocompatibility, the best osteogenesis capability and angiogenesis property among the HR samples of pure Zn, ZMGC, and ZMGCP. Furthermore, the HR ZMGCP displayed complete in vivo biocompatibility, osteogenesis, osteointegration capability, and an appropriate degradation rate, showing significant potential for a biodegradable bone-implant material.
资助项目	Zhejiang Public Welfare Technology Application Research Project of China [LTGY24H140002, LTGY23H140002, LGF22H140008]; Australian Research Council (ARC) [DP240101131]
出版者	KEAI PUBLISHING LTD
ISSN	2452-199X
EISSN	2452-199X
卷号	43 页码:491-509
DOI	10.1016/j.bioactmat.2024.09.026
页数	19
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:001336022900001
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85205759604
通讯作者地址	[Ma, Jianfeng;Lin, Jixing]Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China. ; [Zhou, Runqi]Chongqing Med Univ, Higher Educ & Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn, Chongqing 401174, Peoples R China. ; [Wen, Cuie]RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia.
Scopus学科分类	Biotechnology;Biomaterials;Biomedical Engineering
SCOPUS_ID	SCOPUS_ID:85205759604
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220652
专题	口腔医学院、附属口腔医院口腔医学院、附属口腔医院_口腔医学研究所其他_温州市第三临床学院（温州市人民医院）其他_附属第三医院（瑞安市人民医院）
通讯作者	Zhou, Runqi; Ma, Jianfeng; Wen, Cuie; Lin, Jixing
作者单位	1.Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China; 2.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 3, Ruian Peoples Hosp, Sci & Educ Div, Wenzhou 325016, Peoples R China; 4.Chongqing Med Univ, Higher Educ & Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn, Chongqing 401174, Peoples R China; 5.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia
第一作者单位	口腔医学院、附属口腔医院; 口腔医学研究所
通讯作者单位	口腔医学院、附属口腔医院; 口腔医学研究所
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Tong, Xian,Shen, Xinkun,Lin, Zhiqiang,et al. In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegradable bone-implant applications[J]. Bioactive Materials,2025,43:491-509.
APA	Tong, Xian., Shen, Xinkun., Lin, Zhiqiang., Zhou, Runqi., Han, Yue., ... & Lin, Jixing. (2025). In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegradable bone-implant applications. Bioactive Materials, 43, 491-509.
MLA	Tong, Xian,et al."In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegradable bone-implant applications".Bioactive Materials 43(2025):491-509.