Synthetic Optimization and Antibacterial Activity of Novel Benzodioxepine-Biphenyl Amide Derivatives

doi:10.17344/acsi.2024.8784

科研成果详情

题名	Synthetic Optimization and Antibacterial Activity of Novel Benzodioxepine-Biphenyl Amide Derivatives
作者	Yan, Shao-Peng1,2,3; Zhu, Zhi-Yu1,2,3; Jia, Qi-Ke 2,3; Ji, Rui-Ying1,2,3; Wang, Ya-Pin1,2,3; He, Dan1,2,3; Wang, Rong 1,2,3; Xu, Xiao-Jun 4; Zhou, Yang 1,2,3,5
发表日期	2024
发表期刊	ACTA CHIMICA SLOVENICA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Benzodioxepine amide biphenyl Suzuki coupling antibacterial activity FabH inhibitor
其他关键词	SYNTHASE-III FABH ; DIOXYGENATED RINGS ; CRYSTAL-STRUCTURE ; AGENTS
摘要	The biosynthesis of fatty acids is an important metabolic pathway in bacterial organisms. Previous studies have highligh-ted the synthesis of antimicrobial compounds anchored in the benzodioxepin scaffold and known for their pronounced antibacterial properties. Based on this fundamental knowledge, a series of eight innovative benzodioxepin-biphenyl amide derivatives were carefully designed and synthesized in the current research work. This was achieved through a sophisticated optimization of the synthetic methods. The scope of this study extends to a rigorous evaluation of the an-tibacterial properties and biocompatibility of the above-mentioned new derivatives. In particular, compound E4 proved to be an extremely effective antimicrobial agent. In addition to a detailed elucidation of the crystalline architecture of compound E4, a thorough docking study was also carried out to investigate the interactions with the enzyme FabH.
出版者	SLOVENSKO KEMIJSKO DRUSTVO
ISSN	1318-0207
EISSN	1580-3155
卷号	71 期号:3 页码:509-518
DOI	10.17344/acsi.2024.8784
页数	10
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:001330981600008
收录类别	SCIE
PubMed ID	39324322
通讯作者地址	[Wang, Rong;Zhou, Yang]Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315300, Peoples R China. ; [Wang, Rong;Zhou, Yang]Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Lab Adv Theranost Mat & Technol, Ningbo 315300, Peoples R China. ; [Wang, Rong;Zhou, Yang]Ningbo Cixi Inst Biomed Engn, Ningbo 315300, Peoples R China. ; [Zhou, Yang]Pingshan Translat Med Ctr, Shenzhen Bay Lab, Shenzhen 518118, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220636
专题	其他_温州医科大学慈溪生物医药研究院
通讯作者	Wang, Rong; Zhou, Yang
作者单位	1.Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315300, Peoples R China; 2.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Lab Adv Theranost Mat & Technol, Ningbo 315300, Peoples R China; 3.Ningbo Cixi Inst Biomed Engn, Ningbo 315300, Peoples R China; 4.Zhejiang Pharmaceut Univ, Coll Pharmaceut Engn & Biotechnol, Ningbo 315500, Peoples R China; 5.Pingshan Translat Med Ctr, Shenzhen Bay Lab, Shenzhen 518118, Peoples R China
第一作者单位	其他_温州医科大学慈溪生物医药研究院
通讯作者单位	其他_温州医科大学慈溪生物医药研究院
第一作者的第一单位	其他_温州医科大学慈溪生物医药研究院
推荐引用方式 GB/T 7714	Yan, Shao-Peng,Zhu, Zhi-Yu,Jia, Qi-Ke,et al. Synthetic Optimization and Antibacterial Activity of Novel Benzodioxepine-Biphenyl Amide Derivatives[J]. ACTA CHIMICA SLOVENICA,2024,71(3):509-518.
APA	Yan, Shao-Peng., Zhu, Zhi-Yu., Jia, Qi-Ke., Ji, Rui-Ying., Wang, Ya-Pin., ... & Zhou, Yang. (2024). Synthetic Optimization and Antibacterial Activity of Novel Benzodioxepine-Biphenyl Amide Derivatives. ACTA CHIMICA SLOVENICA, 71(3), 509-518.
MLA	Yan, Shao-Peng,et al."Synthetic Optimization and Antibacterial Activity of Novel Benzodioxepine-Biphenyl Amide Derivatives".ACTA CHIMICA SLOVENICA 71.3(2024):509-518.