Fluorescence imaging-guided lipid droplets-localized photodynamic therapy

doi:10.1002/agt2.665

科研成果详情

题名	Fluorescence imaging-guided lipid droplets-localized photodynamic therapy
作者	Wang, Shan 1; Wang, Qiang2; Lv, Yang3; Liu, Zhe3; Lee, Kippeum 4; Kim, Dongeun 4; Won, Miae 4,5,6; Shen, Jianliang3,7; Kim, Jong Seung 4,6
发表日期	2024-10-01
发表期刊	AGGREGATE 影响因子和分区
语种	英语
原始文献类型	Review ; Early Access
关键词	aggregation-induced emission intramolecular charge transfer lipid droplet photodynamic therapy photosensitizers
其他关键词	MOLECULAR DESIGN ; RECENT PROGRESS ; PROBE ; PHOTOSENSITIZERS ; CANCER
摘要	Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non-invasive nature and high specificity toward malignant tissues. In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle-targeted PDT strategy is supposed to be quite promising. Particularly, lipid droplets (LDs)-localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis. This review provides a comprehensive summary of the advancements of LDs-localized photosensitizers (PSs) according to their chemical structures and functions. Especially, these PSs are featured with fluorescence emission, thereby facilitating an imaging-guided phototherapy. The review highlights the cytocidal actions of these PSs, such as the cell death pathway and their cytotoxicity. Finally, some unresolved issues and challenges in this domain will be discussed. The state-of-the-art advances in the field of fluoresecence imaging-guided lipid droplets-localized photodynamic therapy are comphrehensively summarized in this review. The photosensitizes are introduced according to their structures, as well as their luminescent mechanisms such as aggregation-induced emission and intramolecular charge transfer. image
资助项目	National Natural Science Foundation of China [22207087]; Medical and Health Research Project of Zhejiang Province [2024KY407]; National Research Foundation of Korea [2018R1A3B1052702, RS-2024-00335130]; Starting Growth Technological R&D Program of the Ministry of SMEs and Startups [RS-2024-00422852, S3201803-TIPSProgram2021]
出版者	WILEY
ISSN	2766-8541
EISSN	2692-4560
DOI	10.1002/agt2.665
页数	20
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Materials Science
WOS记录号	WOS:001322617800001
收录类别	ESCI ; EI
EI入藏号	20244017143629
EI主题词	Photosensitizers
EI分类号	102.1.2.1 ; 103 ; 741.1/Optics ; 746 Imaging Techniques
通讯作者地址	[Shen, Jianliang]Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Peoples R China. ; [Won, Miae;Kim, Jong Seung]Korea Univ, Dept Chem, Seoul 02841, South Korea.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220611
专题	附属第一医院眼视光学院（生物医学工程学院）、附属眼视光医院其他_温州市第三临床学院（温州市人民医院）其他_附属第三医院（瑞安市人民医院）
通讯作者	Won, Miae; Shen, Jianliang; Kim, Jong Seung
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Zhejiang Key Lab Crit Care Med, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Ruian, Peoples R China; 3.Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Peoples R China; 4.Korea Univ, Dept Chem, Seoul 02841, South Korea; 5.Dongduk Womens Univ, Coll Pharm, Seoul, South Korea; 6.TheranoChem Inc, R&D Inst, Seoul, South Korea; 7.Univ Chinese Acad Sci, Wenzhou Inst, Zhejiang Engn Res Ctr Tissue Repair Mat, Wenzhou, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Shan,Wang, Qiang,Lv, Yang,et al. Fluorescence imaging-guided lipid droplets-localized photodynamic therapy[J]. AGGREGATE,2024.
APA	Wang, Shan., Wang, Qiang., Lv, Yang., Liu, Zhe., Lee, Kippeum., ... & Kim, Jong Seung. (2024). Fluorescence imaging-guided lipid droplets-localized photodynamic therapy. AGGREGATE.
MLA	Wang, Shan,et al."Fluorescence imaging-guided lipid droplets-localized photodynamic therapy".AGGREGATE (2024).