YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2

doi:10.1038/s44319-024-00276-6

科研成果详情

题名	YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2
作者	Jiangyun Shen1; Liyan Lou1; Xue Du1; Bincheng Zhou1; Yanqi Xu1; Fuqi Mei1; Liangrong Wu 1,2; Jianmin Li3; Ari Waisman 4; Jing Ruan 5; Xu Wang 6
发表日期	2024-09-27
发表期刊	EMBO reports 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Inflammatory Bowel Disease NOD2 RIPK2 Ubiquitination YOD1
其他关键词	NF-KAPPA-B ; NOD2 ; BINDING ; A20 ; SUSCEPTIBILITY ; ENZYME
摘要	Inflammatory bowel disease (IBD) is a disorder causing chronic inflammation in the gastrointestinal tract, and its pathophysiological mechanisms are still under investigation. Here, we find that mice deficient of YOD1, a deubiquitinating enzyme, are highly susceptible to dextran sulfate sodium (DSS)-induced colitis. The bone marrow transplantation experiment reveals that YOD1 derived from hematopoietic cells inhibits DSS colitis. Moreover, YOD1 exerts its protective role by promoting nucleotide-binding oligomerization domain 2 (NOD2)-mediated physiological inflammation in macrophages. Mechanistically, YOD1 inhibits the proteasomal degradation of receptor-interacting serine/threonine kinase 2 (RIPK2) by reducing its K48 polyubiquitination, thereby increasing RIPK2 abundance to enhance NOD2 signaling. Consistently, the protective function of muramyldipeptide, a NOD2 ligand, in experimental colitis is abolished in mice deficient of YOD1. Importantly, YOD1 is upregulated in colon-infiltrating macrophages in patients with colitis. Collectively, this study identifies YOD1 as a novel regulator of colitis.
资助项目	MOST \| National Natural Science Foundation of China (NSFC)[81900496];MOST \| NSFC \| NSFC-Zhejiang Joint Fund \| \| Natural Science Foundation of Zhejiang Province (ZJNSF)[LZ24H090003]
出版者	SPRINGERNATURE
ISSN	1469-221X
EISSN	1469-3178
DOI	10.1038/s44319-024-00276-6
页数	19
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:001324538700003
收录类别	PUBMED ; SCIE
URL	查看原文
PubMed ID	39333628
通讯作者地址	[Wang, Xu]Wenzhou Med Univ, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325035, Peoples R China. ; [Wang, Xu]Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China. ; [Ruan, Jing]Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou 325000, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218993
专题	药学院（分析测试中心）附属第一医院附属第一医院_病理科其他_瓯江实验室
作者单位	1.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health); School of Pharmaceutical Sciences, Wenzhou Medical University, 325035, Wenzhou, China.; 2.Department of Pharmacy, Yiwu Central Hospital, 322099, Yiwu, China.; 3.Department of Pathology, The First Affiliated Hospital, Wenzhou Medical University, 325000, Wenzhou, China.; 4.Institute for Molecular Medicine, Johannes Gutenberg University Mainz, 55131, Mainz, Germany.; 5.Department of Pathology, The First Affiliated Hospital, Wenzhou Medical University, 325000, Wenzhou, China. ruanjing850617@163.com.; 6.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health); School of Pharmaceutical Sciences, Wenzhou Medical University, 325035, Wenzhou, China. sunrim@163.com.
第一作者单位	药学院（分析测试中心）; 瓯江实验室
通讯作者单位	温州医科大学; 药学院（分析测试中心）; 附属第一医院; 病理科
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Jiangyun Shen,Liyan Lou,Xue Du,et al. YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2[J]. EMBO reports,2024.
APA	Jiangyun Shen., Liyan Lou., Xue Du., Bincheng Zhou., Yanqi Xu., ... & Xu Wang. (2024). YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2. EMBO reports.
MLA	Jiangyun Shen,et al."YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2".EMBO reports (2024).