Computed tomography-based body composition indicative of diabetes after hypertriglyceridemic acute pancreatitis

doi:10.1016/j.diabres.2024.111862

科研成果详情

题名	Computed tomography-based body composition indicative of diabetes after hypertriglyceridemic acute pancreatitis
作者	Huang, Yingbao 1,2; Zhu, Yi 3; Xia, Weizhi4; Xie, Huanhuan 1; Yu, Huajun 5; Chen, Lifang2; Shi, Liuzhi6; Yu, Risheng 1
发表日期	2024-11-01
发表期刊	Diabetes Research and Clinical Practice 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Acute pancreatitis Body composition Computed tomography Diabetes Machine learning
其他关键词	ADIPOSE-TISSUE ; 1ST ATTACK ; MELLITUS ; RISK ; STRESS ; 3C
摘要	Background: Post‑acute pancreatitis prediabetes/diabetes mellitus (PPDM‑A) is one of the common sequelae of acute pancreatitis (AP). The aim of our study was to build a machine learning (ML)-based prediction model for PPDM-A in hypertriglyceridemic acute pancreatitis (HTGP). Methods: We retrospectively enrolled 165 patients for our study. Demographic and laboratory data and body composition were collected. Multivariate logistic regression was applied to select features for ML. Support vector machine (SVM), linear discriminant analysis (LDA), and logistic regression (LR) were used to develop prediction models for PPDM-A. Results: 65 patients were diagnosed with PPDM-A, and 100 patients were diagnosed with non-PPDM-A. Of the 84 body composition-related parameters, 15 were significant in discriminating between the PPDM-A and non-PPDM-A groups. Using clinical indicators and body composition parameters to develop ML models, we found that the SVM model presented the best predictive ability, obtaining the best AUC=0.796 in the training cohort, and the LDA and LR model showing an AUC of 0.783 and 0.745, respectively. Conclusions: The association between body composition and PPDM-A provides insight into the potential pathogenesis of PPDM-A. Our model is feasible for reliably predicting PPDM-A in the early stages of AP and enables early intervention in patients with potential PPDM-A.
资助项目	Zhejiang University Clinical Medicine Innovation Center for the Diagnosis and Treatment of Hepatobiliary and Pancreatic Diseases[2013TD06];Medical Science and Technology Project of Zhejiang Province[2024KY140];Science and Technology Plan Project of Wenzhou Municipality[Y20210229];
出版者	ELSEVIER IRELAND LTD
ISSN	0168-8227
EISSN	1872-8227
卷号	217
DOI	10.1016/j.diabres.2024.111862
页数	9
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001319716600001
收录类别	SCOPUS ; PUBMED ; SCIE
URL	查看原文
PubMed ID	39299391
SCOPUSEID	2-s2.0-85204238258
通讯作者地址	[Yu, Risheng]Department of Radiology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China
Scopus学科分类	Internal Medicine;Endocrinology, Diabetes and Metabolism;Endocrinology
SCOPUS_ID	SCOPUS_ID:85204238258
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218871
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院第一临床医学院（信息与工程学院）、附属第一医院_临床检验诊断学
通讯作者	Yu, Risheng
作者单位	1.Department of Radiology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China; 2.Department of Radiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 4.Department of Radiology,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 5.Department of Hepatobiliary Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 6.Department of Clinical Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Huang, Yingbao,Zhu, Yi,Xia, Weizhi,et al. Computed tomography-based body composition indicative of diabetes after hypertriglyceridemic acute pancreatitis[J]. Diabetes Research and Clinical Practice,2024,217.
APA	Huang, Yingbao., Zhu, Yi., Xia, Weizhi., Xie, Huanhuan., Yu, Huajun., ... & Yu, Risheng. (2024). Computed tomography-based body composition indicative of diabetes after hypertriglyceridemic acute pancreatitis. Diabetes Research and Clinical Practice, 217.
MLA	Huang, Yingbao,et al."Computed tomography-based body composition indicative of diabetes after hypertriglyceridemic acute pancreatitis".Diabetes Research and Clinical Practice 217(2024).