Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters

doi:10.1016/j.heliyon.2024.e37419

科研成果详情

题名	Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters
作者	Li, Ling 1,2; Dai, Fangyu1; Xu, Jie 1; Dong, Jiaoxuan 1; Wu, Bin 3; He, Songbin 1,4; Liu, Haipeng 5
发表日期	2024-09-30
发表期刊	Heliyon 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Carotid atherosclerotic plaque Computed tomography angiography (CTA) Plaque morphology Stroke Three-dimensional reconstruction
摘要	The three-dimensional (3D) geometry of carotid atherosclerotic plaques is associated with multiple cardiovascular diseases. However, it is unknown if carotid plaques of different sizes are consistent in 3D geometry, with a lack of quantitative observation. We aim to evaluate the geometric consistency of carotid plaques using the correlations between multidimensional parameters. 42 cases with asymptomatic stenosis caused by atherosclerotic plaque in the carotid artery were included. Carotid plaques and calcifications were identified on computed tomography angiography images and 3D reconstructed. Multidimensional geometric parameters (length, surface area, volume, etc.) were measured on the reconstructed 3D structures. Linear and non-linear (power function) fittings were used to investigate the relationships between multidimensional parameters. The analysis was performed based on cases and plaques, respectively. Spearman rank correlation analysis, R-squared, and p-values were used to evaluate the significance of the relationship. Significant relationship was defined as R-squared >0.25 and p < 0.05. In total, 112 atherosclerotic plaques and 74 calcifications were extracted. In plaque-based analysis, significant correlations were widely observed between paired multidimensional parameters of carotid plaques, where non-linear fitting showed higher R-squared values. Plaque volume and surface area were significantly correlated with total volume and total surface area of intra-plaque calcifications. In subject-based analysis, triglycerides and total cholesterol were significantly correlated with carotid plaque size. There is a consistency in geometry among carotid atherosclerotic plaques of different sizes. The size of a carotid plaque is associated with the patient's lipid profile.
资助项目	Medical and Health Science and Technology Plan Project of Zhoushan and Medical Health Science and Technology Project of Zhejiang Provincial Health Commission[2021YA07,2022KY1367];Medical and Health Science and Technology Plan Project of Zhoushan[2020C31048];
ISSN	2405-8440
卷号	10 期号:18
DOI	10.1016/j.heliyon.2024.e37419
收录类别	SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39309847
SCOPUSEID	2-s2.0-85203402942
通讯作者地址	[Liu, Haipeng]Centre for Intelligent Healthcare,Coventry University,Coventry,CV1 5RW,United Kingdom
Scopus学科分类	Multidisciplinary
SCOPUS_ID	SCOPUS_ID:85203402942
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218850
专题	其他_附属舟山医院（舟山医院）
通讯作者	Liu, Haipeng
作者单位	1.Department of Neurology,Zhoushan Hospital,Wenzhou Medical University,Zhejiang Province,Zhoushan,316000,China; 2.Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong,China; 3.Department of Neurology,People's Hospital of Quzhou,Zhejiang Province,Quzhou,324002,China; 4.Department of Neurology,Zhoushan Hospital,Zhejiang University,School of Medicine,Zhejiang Province,Zhoushan,316000,China; 5.Centre for Intelligent Healthcare,Coventry University,Coventry,CV1 5RW,United Kingdom
第一作者单位	其他_附属舟山医院（舟山医院）
第一作者的第一单位	其他_附属舟山医院（舟山医院）
推荐引用方式 GB/T 7714	Li, Ling,Dai, Fangyu,Xu, Jie,et al. Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters[J]. Heliyon,2024,10(18).
APA	Li, Ling., Dai, Fangyu., Xu, Jie., Dong, Jiaoxuan., Wu, Bin., ... & Liu, Haipeng. (2024). Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters. Heliyon, 10(18).
MLA	Li, Ling,et al."Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters".Heliyon 10.18(2024).