Hsa_circ_0006010 and hsa_circ_0002903 in peripheral blood serve as novel diagnostic, surveillance and prognostic biomarkers for disease progression in chronic myeloid leukemia

doi:10.1186/s12885-024-12943-x

科研成果详情

题名	Hsa_circ_0006010 and hsa_circ_0002903 in peripheral blood serve as novel diagnostic, surveillance and prognostic biomarkers for disease progression in chronic myeloid leukemia
作者	Zhao, Jingwei1,2; Wang, Guiran1,2,3; Yan, Guiling 1,2; Zheng, Mengting1,2; Li, Hongshuang1,2; Bai, Yuanyuan1,2; Zheng, Xiaoqun1,2,4; Chen, Zhanguo1,2,5
发表日期	2024-09-20
发表期刊	BMC Cancer 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hsa_circ_0006010 Hsa_circ_0002903 Chronic myeloid leukemia Disease progression Diagnosis Surveillance Prognostic biomarkers
其他关键词	SURVIVAL ; EXPRESSION
摘要	Background In the era of tyrosine kinase inhibitor (TKI) treatment, the progression of chronic myeloid leukemia (CML) remains a significant clinical challenge, and genetic biomarkers for the early identification of CML patients at risk for progression are limited. This study explored whether essential circular RNAs (circRNAs) can be used as biomarkers for diagnosing and monitoring CML disease progression and assessing CML prognosis. Methods Peripheral blood (PB) samples were collected from 173 CML patients (138 patients with chronic phase CML [CML-CP] and 35 patients with accelerated phase/blast phase CML [CML-AP/BP]) and 63 healthy controls (HCs). High-throughput RNA sequencing (RNA-Seq) was used to screen dysregulated candidate circRNAs for a circRNA signature associated with CML disease progression. Quantitative real-time PCR (qRT-PCR) was used for preliminary verification and screening of candidate dysregulated genes, as well as subsequent exploration of clinical applications. Receiver operating characteristic (ROC) curve analysis, Spearman's rho correlation test, and the Kaplan-Meier method were used for statistical analysis. Results The aberrant expression of hsa_circ_0006010 and hsa_circ_0002903 during CML progression could serve as valuable biomarkers for differentiating CML-AP/BP patients from CMP-CP patients or HCs. In addition, the expression levels of hsa_circ_0006010 and hsa_circ_0002903 were significantly associated with the clinical features of CML patients but were not directly related to the four scoring systems. Furthermore, survival analysis revealed that high hsa_circ_0006010 expression and low hsa_circ_0002903 expression indicated poor progression-free survival (PFS) in CML patients. Finally, PB hsa_circ_0006010 and hsa_circ_0002903 expression at diagnosis may also serve as disease progression surveillance markers for CML patients but were not correlated with PB BCR-ABL1/ABL1(IS). Conclusions Our study demonstrated that PB levels of hsa_circ_0006010 and hsa_circ_0002903 may serve as novel diagnostic, surveillance, and prognostic biomarkers for CML disease progression and may contribute to assisting in the diagnosis of CML patients at risk for progression and accurate management of advanced CML patients.
资助项目	Medical and Health Research Science and Technology Plan Project of Zhejiang Province [2021KY216]; Basic Public Welfare Technology Research Project of Zhejiang Province [LGF20H200005]; Basic Scientific Research Project of Wenzhou City [Y20220123, Y20220744]
出版者	BMC
ISSN	1471-2407
EISSN	1471-2407
卷号	24 期号:1
DOI	10.1186/s12885-024-12943-x
页数	16
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001317452300005
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	3930486
SCOPUSEID	2-s2.0-85204512526
通讯作者地址	[Zheng, Xiaoqun;Chen, Zhanguo]Wenzhou Med Univ, Affiliated Hosp 2, Dept Clin Lab, 1111 Wenzhou Ave, Wenzhou 325024, Zhejiang, Peoples R China. ; [Zheng, Xiaoqun;Chen, Zhanguo]Wenzhou Med Univ, Yuying Childrens Hosp, 1111 Wenzhou Ave, Wenzhou 325024, Zhejiang, Peoples R China. ; [Zheng, Xiaoqun]Wenzhou Med Univ, Sch Lab Med & Life Sci, Key Lab Lab Med, Minist Educ China, Wenzhou 325035, Zhejiang, Peoples R China. ; [Chen, Zhanguo]Wenzhou Med Univ, Affiliated Hosp 2, Yuying Childrens Hosp, Key Lab Pediat Hematol & Oncol Dis Wenzhou, Wenzhou 325027, Zhejiang, Peoples R China.
Scopus学科分类	Oncology;Genetics;Cancer Research
SCOPUS_ID	SCOPUS_ID:85204512526
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218785
专题	附属第二医院检验医学院（生命科学学院、生物学实验教学中心）附属第一医院附属第一医院_病理科第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Zheng, Xiaoqun; Chen, Zhanguo
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Clin Lab, 1111 Wenzhou Ave, Wenzhou 325024, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, 1111 Wenzhou Ave, Wenzhou 325024, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou 325036, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Sch Lab Med & Life Sci, Key Lab Lab Med, Minist Educ China, Wenzhou 325035, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 2, Yuying Childrens Hosp, Key Lab Pediat Hematol & Oncol Dis Wenzhou, Wenzhou 325027, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 检验医学院（生命科学学院、生物学实验教学中心）
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Zhao, Jingwei,Wang, Guiran,Yan, Guiling,et al. Hsa_circ_0006010 and hsa_circ_0002903 in peripheral blood serve as novel diagnostic, surveillance and prognostic biomarkers for disease progression in chronic myeloid leukemia[J]. BMC Cancer,2024,24(1).
APA	Zhao, Jingwei., Wang, Guiran., Yan, Guiling., Zheng, Mengting., Li, Hongshuang., ... & Chen, Zhanguo. (2024). Hsa_circ_0006010 and hsa_circ_0002903 in peripheral blood serve as novel diagnostic, surveillance and prognostic biomarkers for disease progression in chronic myeloid leukemia. BMC Cancer, 24(1).
MLA	Zhao, Jingwei,et al."Hsa_circ_0006010 and hsa_circ_0002903 in peripheral blood serve as novel diagnostic, surveillance and prognostic biomarkers for disease progression in chronic myeloid leukemia".BMC Cancer 24.1(2024).