Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling

doi:10.1016/j.phymed.2024.155976

科研成果详情

题名	Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling
作者	Yao, Yizhu 1; Song, Lanlan 1; Zuo, Ziyi1; Chen, Zhili 1; Wang, Yijia 1; Cai, Haijian 1; Gu, Yanting1; Lv, Zhanghang1; Guan, Jiale 2; Chen, Rujie2; Wang, Boxiang 2; Yang, Lehe 1; Huang, Xiaoying 1; Wang, Liangxing1
发表日期	2024-11
发表期刊	Phytomedicine 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Parthenolide Pulmonary arterial hypertension STAT3 Proliferation Apoptosis
其他关键词	APOPTOSIS ; PROLIFERATION
摘要	Background: Pulmonary hypertension (PH) is a chronic lung disease characterized by the progressive pulmonary vascular remodeling with increased pulmonary arterial pressure and right ventricular failure. Pulmonary vascular remodeling involves the proliferation, migration, and resistance to apoptosis of pulmonary artery smooth cells (PASMCs). Parthenolide (PTN) is a bioactive compound derived from a traditional medical plant feverfew (Tanacetum parthenium), and it has been studied for treatment of pulmonary fibrosis, lung cancer, and other related ailments. However, the function of PTN in the treatment of PH has not been studied. Purpose: This study aimed to evaluate the anti-proliferation and pro-apoptosis effects of PTN on PH and investigate its potential mechanisms. Methods: An in vivo hypoxia-induced pulmonary hypertension (HPH) model was established by maintaining male rats in a hypoxia chamber (10% O2) for 3 weeks, and PTN was intraperitoneally administered at the dose of 10 or 30 mg/kg. We assessed the impact of PTN on mean pulmonary arterial pressure (mPAP), pulmonary vascular remodeling, and right ventricular hypertrophy. In vitro, we evaluated hypoxia-induced cellular proliferation, migration, and apoptosis of rat PASMCs. Proteins related to the STAT3 signaling axis were analyzed by western blotting and immunofluorescence assays. Recovery experiments were performed using the STAT3 activator, colivelin TFA. Results: PTN significantly alleviated the symptoms of HPH rats by attenuating pulmonary arterial remodeling. It also prevented the proliferation and migration of PASMCs. PTN also induced the apoptosis of PASMCs. PTN could directly interact with STAT3 and markedly inhibited STAT3 phosphorylation and nuclear translocation. In vitro, and in vivo experiments demonstrated that overexpression of STAT3 partially suppressed the effect of PTN. Conclusion: Our study indicated that PTN alleviated hypoxia-induced pulmonary hypertension in rats by suppressing STAT3 activity.
资助项目	Natural Science Foundation of Zhejiang province [LZ23H010001]; National Natural Science Foundation of China [82170061, 82170062]; Key Laboratory of Heart and Lung of Wenzhou Medical University
出版者	ELSEVIER GMBH
ISSN	0944-7113
EISSN	1618-095X
卷号	134
DOI	10.1016/j.phymed.2024.155976
页数	14
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS记录号	WOS:001315368200001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39265445
SCOPUSEID	2-s2.0-85203511808
通讯作者地址	[Yang, Lehe;Huang, Xiaoying;Wang, Liangxing]Wenzhou Med Univ, Affiliated Hosp 1, Pulm Div, Wenzhou 325035, Zhejiang, Peoples R China.
Scopus学科分类	Molecular Medicine;Pharmacology;Pharmaceutical Science;Drug Discovery;Complementary and Alternative Medicine
SCOPUS_ID	SCOPUS_ID:85203511808
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218777
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_硕士
通讯作者	Yang, Lehe; Huang, Xiaoying; Wang, Liangxing
作者单位	1.Wenzhou Med Univ, Pulm Div, Wenzhou Key Lab Interdiscipline & Translat Med, Wenzhou Key Lab Heart & Lung,Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Clin Med Coll 1, Wenzhou 325035, Zhejiang, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yao, Yizhu,Song, Lanlan,Zuo, Ziyi,et al. Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling[J]. Phytomedicine,2024,134.
APA	Yao, Yizhu., Song, Lanlan., Zuo, Ziyi., Chen, Zhili., Wang, Yijia., ... & Wang, Liangxing. (2024). Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling. Phytomedicine, 134.
MLA	Yao, Yizhu,et al."Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling".Phytomedicine 134(2024).