The Significance of Lymph Node Dissection in Patients with Early Epithelial Ovarian Cancer

doi:10.62713/aic.3353

科研成果详情

题名	The Significance of Lymph Node Dissection in Patients with Early Epithelial Ovarian Cancer
作者	Bao, Ruru1; Olivier, Mpano 2; Xiang, Junmiao 1; Ye, Piaopiao 2; Yan, Xiaojian2
发表日期	2024-08
发表期刊	ANNALI ITALIANI DI CHIRURGIA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	early ovarian cancer lymph node dissection prognosis
其他关键词	SYSTEMATIC LYMPHADENECTOMY ; METASTASIS ; PREDICTION
摘要	AIM: This study aimed to investigate the impact of lymph node dissection on the prognosis of early epithelial ovarian cancer and to assess the factors associated with lymph node metastasis. METHODS: In this retrospective study, we collected and analyzed the demographic characteristics, clinical pathological data, and perioperative adverse events in newly diagnosed early epithelial ovarian cancer (EOC) patients, Federation International of Gynecology and Obstetrics (FIGO) stage IA-IIA. The patients underwent surgical treatment at the First, Second, and Third Affiliated Hospitals of Wenzhou Medical University in Zhejiang Province, China, between June 2012 and June 2022. The survival analysis was performed. RESULTS: We enrolled 284 patients in this study, including 246 stage I, 28 stage II, and 10 stage III patients after surgery. Among them, 42 patients did not undergo lymph node dissection, 113 underwent pelvic lymph node dissection only, and 129 underwent pelvic plus para-aortic lymph node dissection. Among the lymph node dissection group, only 8 patients had lymph node metastasis (8/242, 3.3%), including 6 with pelvic lymph node metastasis and 2 with pelvic plus para-aortic lymph node metastasis. The median follow-up duration was 63 months. The systematic lymph node dissection group significantly prolonged the median operation duration and increased intraoperative blood loss and postoperative complications (p <0.05). Postoperative multivariate Cox regression analysis revealed FIGO stage III as an independent risk factor for Progression-Free-Survival (PFS) and Overall Survival (OS) (p < 0.05). Furthermore, the preoperative cancer antigen 125 (CA125) level was observed as an independent factor affecting lymph node metastasis. CONCLUSIONS: Systematic lymph node dissection showed minimal effect on the survival rate of patients with clinically apparent early epithelial ovarian cancer and increased the postoperative complications of patients.
出版者	EDIZIONI LUIGI POZZI
ISSN	0003-469X
EISSN	2239-253X
卷号	95 期号:4 页码:628-635
DOI	10.62713/aic.3353
页数	8
WOS类目	Surgery
WOS研究方向	Surgery
WOS记录号	WOS:001300260600023
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	39186355
SCOPUSEID	2-s2.0-85202267242
通讯作者地址	[Yan, Xiaojian]Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Surgery
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218765
专题	其他_附属第三医院（瑞安市人民医院）附属第一医院_妇科
通讯作者	Yan, Xiaojian
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 3, Dept Gynecol, Ruian 325200, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	其他_附属第三医院（瑞安市人民医院）
通讯作者单位	附属第一医院_妇科
第一作者的第一单位	其他_附属第三医院（瑞安市人民医院）
推荐引用方式 GB/T 7714	Bao, Ruru,Olivier, Mpano,Xiang, Junmiao,et al. The Significance of Lymph Node Dissection in Patients with Early Epithelial Ovarian Cancer[J]. ANNALI ITALIANI DI CHIRURGIA,2024,95(4):628-635.
APA	Bao, Ruru, Olivier, Mpano, Xiang, Junmiao, Ye, Piaopiao, & Yan, Xiaojian. (2024). The Significance of Lymph Node Dissection in Patients with Early Epithelial Ovarian Cancer. ANNALI ITALIANI DI CHIRURGIA, 95(4), 628-635.
MLA	Bao, Ruru,et al."The Significance of Lymph Node Dissection in Patients with Early Epithelial Ovarian Cancer".ANNALI ITALIANI DI CHIRURGIA 95.4(2024):628-635.