Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases

doi:10.3389/fcell.2024.1431883

科研成果详情

题名	Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases
作者	Li, Hui1; Chen, Lixia1; Liu, Meikuai 1; Bao, Meng1; Zhang, Quanbo2; Xu, Shihao1
发表日期	2024-09-05
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	breast cancer multimodal ultrasound lymph node metastases LASSO regression shear wave elastography contrast-enhanced ultrasound
其他关键词	LESIONS
摘要	Background: Sentinel lymph node metastasis (SLNM) is a critical factor in the prognosis and treatment planning for breast cancer (BC), as it indicates the potential spread of cancer to other parts of the body. The accurate prediction and diagnosis of SLNM are essential for improving clinical outcomes and guiding treatment decisions. Objective: This study aimed to construct a Lasso regression model by integrating multimodal ultrasound (US) techniques, including US, shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS), to improve the predictive accuracy of sentinel lymph node metastasis in breast cancer and provide more precise guidance for clinical treatment. Results: A total of 253 eligible samples were screened, of which 148 were group benign and 105 were group malignant. There were statistically significant differences (p < 0.05) between group malignant patients in terms of age, palpable mass, body mass index, distance to nipple, maximum diameter, blood flow, microcalcification, 2D border, 2D morphology, and 2D uniformity and group benign. The Lasso regression model was useful in the diagnosis of benign and malignant nodules with an AUC of 0.966 and in diagnosing SLNM with an AUC of 0.832. Conclusion: In this study, we successfully constructed and validated a Lasso regression model based on the multimodal ultrasound technique for predicting whether SLNM occurs in BCs, showing high diagnostic accuracy.
资助项目	Wenzhou Municipal Bureau of Science and Technology, Diagnostic Value of Multimodal Ultrasound for Breast Cancer and Model Establishment for Predicting Sentinel Lymph Node Metastasis [Y20220451]; Key Research and Development Program of Zhejiang Province [2021C03003]
出版者	FRONTIERS MEDIA SA
ISSN	2296-634X
卷号	12
DOI	10.3389/fcell.2024.1431883
页数	15
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
WOS记录号	WOS:001316240300001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39300993
通讯作者地址	[Xu, Shihao]Wenzhou Med Univ, Affiliated Hosp 1, Dept Ultrasound Imaging, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218763
专题	附属第一医院_超声影像科附属第一医院_病理科
通讯作者	Xu, Shihao
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Ultrasound Imaging, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou, Peoples R China
第一作者单位	附属第一医院_超声影像科
通讯作者单位	附属第一医院_超声影像科
第一作者的第一单位	附属第一医院_超声影像科
推荐引用方式 GB/T 7714	Li, Hui,Chen, Lixia,Liu, Meikuai,et al. Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2024,12.
APA	Li, Hui, Chen, Lixia, Liu, Meikuai, Bao, Meng, Zhang, Quanbo, & Xu, Shihao. (2024). Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 12.
MLA	Li, Hui,et al."Diagnostic value of multimodal ultrasound for breast cancer and prediction of sentinel lymph node metastases".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 12(2024).