Combined Chemo- and Photothermal Therapies of Non-Small Cell Lung Cancer Using Polydopamine/Au Hollow Nanospheres Loaded with Doxorubicin

doi:10.2147/IJN.S473137

科研成果详情

题名	Combined Chemo- and Photothermal Therapies of Non-Small Cell Lung Cancer Using Polydopamine/Au Hollow Nanospheres Loaded with Doxorubicin
作者	Zhang, Xinbo; Xu, Bin; Ni, Jiangwei; Xiang, Yucheng; He, Zhifeng
发表日期	2024
发表期刊	INTERNATIONAL JOURNAL OF NANOMEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	non-small cell lung cancer chemotherapy photothermal therapy doxorubicin Au nanoparticles
其他关键词	NANOPARTICLES ; ATLANTIS
摘要	Purpose: The chemotherapeutic agent doxorubicin (DOX) is limited by its cardiotoxicity, posing challenges in its application for nonsmall cell lung cancer (NSCLC). This study aims to explore the efficacy of polydopamine/Au nanoparticles loaded with DOX for chemotherapy and photothermal therapy in NSCLC to achieve enhanced efficacy and reduced toxicity. Methods: Hollow polydopamine (HPDA)/Au@DOX was synthesized via polydopamine chemical binding sacrificial template method. Morphology was characterized using transmission electron microscopy, particle size and potential were determined using dynamic light scattering, and photothermal conversion efficiency was assessed using near-infrared (NIR) thermal imaging. Drug loading rate and in vitro drug release were investigated. In vitro, anti-tumor experiments were conducted using CCK-8 assay, flow cytometry, and live/dead cell staining to evaluate the cytotoxicity of HPDA/Au@DOX on A549 cells. Uptake of HPDA/Au@DOX by A549 cells was detected using the intrinsic fluorescence of DOX. The in vivo anti-metastasis and anti-tumor effects of HPDA/ Au@DOX were explored in mouse lung metastasis and subcutaneous tumor models, respectively. Results: HPDA/Au@DOX with a particle size of (164.26 +/- 3.25) nm, a drug loading rate of 36.31%, and an encapsulation efficiency of 90.78% was successfully prepared. Under 808 nm laser irradiation, HPDA/Au@DOX accelerated DOX release and enhanced uptake by A549 cells. In vitro photothermal performance assessment showed excellent photothermal conversion capability and stability of HPDA/Au@DOX under NIR laser irradiation. Both in vitro and in vivo experiments demonstrated that the photothermalchemotherapy combination group (HPDA/Au@DOX+NIR) exhibited stronger anti-metastatic and anti-tumor activities compared to the monotherapy group (DOX). Conclusion: HPDA/Au@DOX nanosystem demonstrated excellent photothermal effect, inhibiting the growth and metastasis of A549 cells. This nanosystem achieves the combined effect of chemotherapy and photothermal, making it promising for NSCLC treatment.
资助项目	Wenzhou Science and Technology Bureau Project [2022Y0370]
出版者	DOVE MEDICAL PRESS LTD
ISSN	1178-2013
EISSN	1178-2013
卷号	19 页码:9597-9612
DOI	10.2147/IJN.S473137
页数	16
WOS类目	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS记录号	WOS:001314914000001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39296938
通讯作者地址	[He, Zhifeng]Wenzhou Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Wenzhou, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218757
专题	附属第一医院附属第一医院_心胸外科
通讯作者	He, Zhifeng
作者单位	Wenzhou Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 心胸外科
通讯作者单位	附属第一医院; 心胸外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Xinbo,Xu, Bin,Ni, Jiangwei,et al. Combined Chemo- and Photothermal Therapies of Non-Small Cell Lung Cancer Using Polydopamine/Au Hollow Nanospheres Loaded with Doxorubicin[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2024,19:9597-9612.
APA	Zhang, Xinbo, Xu, Bin, Ni, Jiangwei, Xiang, Yucheng, & He, Zhifeng. (2024). Combined Chemo- and Photothermal Therapies of Non-Small Cell Lung Cancer Using Polydopamine/Au Hollow Nanospheres Loaded with Doxorubicin. INTERNATIONAL JOURNAL OF NANOMEDICINE, 19, 9597-9612.
MLA	Zhang, Xinbo,et al."Combined Chemo- and Photothermal Therapies of Non-Small Cell Lung Cancer Using Polydopamine/Au Hollow Nanospheres Loaded with Doxorubicin".INTERNATIONAL JOURNAL OF NANOMEDICINE 19(2024):9597-9612.