Association of non-high-density lipoprotein to high-density lipoprotein ratio (NHHR) with prognosis in cancer survivors: a population-based study in the United States

doi:10.3389/fnut.2024.1430835

科研成果详情

题名	Association of non-high-density lipoprotein to high-density lipoprotein ratio (NHHR) with prognosis in cancer survivors: a population-based study in the United States
作者	Xie, Wenxia1; Liu, Huizhuo1; Lin, Qiaoxin1; Lian, Liyou 2; Liang, Bin1
发表日期	2024-09-04
发表期刊	FRONTIERS IN NUTRITION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	non-HDL-C/HDL-C (NHHR) cancer survivors all-cause mortality cardiac-specific mortality cancer-specific mortality NHANES
其他关键词	CARDIOVASCULAR-DISEASE ; TOTAL CHOLESTEROL ; RISK ; HDL
摘要	Background: Patients with cancer frequently exhibit alterations in serum lipid profiles associated with chemotherapy. It has been reported that lipid distribution in cancer correlates with tumor progression. However, the prognostic value of serum lipid biomarkers in cancer survivors remains a subject of debate. We aim to explore the relationship between non-high-density lipoprotein to high-density lipoprotein ratio (NHHR) and the prognosis of cancer survivors. Methods: In this study, we analyzed cancer survivor data from the National Health and Nutrition Examination Survey (NHANES) from 1999-2000 to 2017-2018. The study included prospective cohorts that included total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels as well as mortality data. Weighted multivariate cox regression models, competing risk models and restricted cubic spline (RCS) models were applied to investigate the association between NHHR and cancer survival. Subgroup and sensitivity analyses were performed to test the robustness of the results. Results: This study involved 4,177 participants, representing about 19.6 million U.S. adults. After adjustment for various factors, the lower NHHR group (<= 1.64) had a 31% (HR 1.31; 95% CI [1.11,1.54], p = 0.001) higher risk of death from any cause compared to the higher NHHR group. The link between NHHR and mortality remained stable across most subgroups, with notable interactions for smoking (p = 0.006) and diabetes status (p = 0.046). A J-shaped pattern was observed between NHHR and all-cause mortality, significantly among obesity-related cancer survivors (overall association test p-value = 0.0068, non-linear association test p-value = 0.0016). However, a non-significant negative correlation was observed for cancer-specific mortality (overall association test p-value = 0.48, non-linear association test p-value = 0.66). Considering the competitive risk of heart disease and cancer-specific mortality, there is no difference between the high and low NHHR groups, while the low NHHR group showed an increased risk of non-specific causes of death (p < 0.001). Conclusion: The results of this study suggest that NHHR is an important indicator that is strongly associated with all-cause mortality in cancer survivors, and that this relationship may be influenced by the interaction of diabetes and smoking status. This finding may provide important information for future research and patient management.
出版者	FRONTIERS MEDIA SA
ISSN	2296-861X
卷号	11
DOI	10.3389/fnut.2024.1430835
页数	15
WOS类目	Nutrition & Dietetics
WOS研究方向	Nutrition & Dietetics
WOS记录号	WOS:001315392000001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39296499
通讯作者地址	[Liang, Bin]Wenzhou Med Univ, Affiliated Hosp 1, Dept Oncol, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218751
专题	附属第一医院附属第一医院_肿瘤外科
通讯作者	Liang, Bin
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Oncol, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Internal Med, Wenzhou, Peoples R China
第一作者单位	附属第一医院; 肿瘤外科
通讯作者单位	附属第一医院; 肿瘤外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xie, Wenxia,Liu, Huizhuo,Lin, Qiaoxin,et al. Association of non-high-density lipoprotein to high-density lipoprotein ratio (NHHR) with prognosis in cancer survivors: a population-based study in the United States[J]. FRONTIERS IN NUTRITION,2024,11.
APA	Xie, Wenxia, Liu, Huizhuo, Lin, Qiaoxin, Lian, Liyou, & Liang, Bin. (2024). Association of non-high-density lipoprotein to high-density lipoprotein ratio (NHHR) with prognosis in cancer survivors: a population-based study in the United States. FRONTIERS IN NUTRITION, 11.
MLA	Xie, Wenxia,et al."Association of non-high-density lipoprotein to high-density lipoprotein ratio (NHHR) with prognosis in cancer survivors: a population-based study in the United States".FRONTIERS IN NUTRITION 11(2024).