The clinical outcome of minor changes in serum creatinine for patients after curative gastrectomy: a prospective study

doi:10.3389/fonc.2024.1416888

科研成果详情

题名	The clinical outcome of minor changes in serum creatinine for patients after curative gastrectomy: a prospective study
作者	Cai, Wen-Tao1; Zeng, Xiu-Ya 2; Huang, Yun-Shi1; Chen, Wei-Sheng 3; Chen, Xiang-Jian1; Xie, Xian-Hai1
发表日期	2024-08-21
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	gastric cancer serum creatinine changes postoperative outcomes nomogram prospective study
其他关键词	PREOPERATIVE RENAL-INSUFFICIENCY ; ACUTE KIDNEY INJURY ; GASTRIC-CANCER ; LAPAROSCOPIC GASTRECTOMY ; COMPLICATIONS ; SURGERY ; ASSOCIATION ; SARCOPENIA ; DISEASE ; IMPACT
摘要	Introduction: Patients with renal insufficiency are more prone to postoperative complications (PCs). Studies have shown that minor changes in serum creatinine (SCr), immediately post-surgery, can aid in assessing patients' renal function. This study aimed to explore the relationship between the changes in SCr and PCs in patients with gastric cancer (GC). Materials and methods: We prospectively collected data regarding the SCr of 530 GC patients, within 2 weeks before surgery and within 24 hours after surgery in our hospital (2014-2016). The patients were divided into three groups according to the level of SCr change after surgery: reduced (<10%), normal (10%), and elevated (>10%) creatinine groups. Univariate and multivariate logistic analysis were performed to evaluate its correlation with short-term PCs in the patients. The R language was used to construct a nomogram. Results: 83, 217, and 230 patients were assigned to the elevated, reduced, and normal SCr groups, respectively. Multivariate analysis showed that the reduced and elevated SCr groups were independently associated with the occurrence of PCs and severe postoperative complications (SPCs), respectively. Additionally, postsurgical SCr change, age, hypoalbuminemia, total gastrectomy, combined resection, and laparoscopy, were independently related to PCs. Combining the above influential factors, the predictive model can distinguish patients with PCs more reliably (c-index is 0.715). Conclusion: Post-surgery, reduced SCr is a protective factor for PCs, while elevated serum creatinine is an independent risk factor for SPCs. Our nomogram can identify GC patients with high risks of PCs.
出版者	FRONTIERS MEDIA SA
ISSN	2234-943X
卷号	14
DOI	10.3389/fonc.2024.1416888
页数	13
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001304928000001
收录类别	SCIE
PubMed ID	39234398
通讯作者地址	[Chen, Xiang-Jian;Xie, Xian-Hai]Wenzhou Med Univ, Affiliated Hosp 1, Dept Traumat Surg, Wenzhou, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218740
专题	附属第一医院附属第一医院_胃肠外科
通讯作者	Chen, Xiang-Jian; Xie, Xian-Hai
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Traumat Surg, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Acupuncture Massage & Phys Therapy, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Cai, Wen-Tao,Zeng, Xiu-Ya,Huang, Yun-Shi,et al. The clinical outcome of minor changes in serum creatinine for patients after curative gastrectomy: a prospective study[J]. FRONTIERS IN ONCOLOGY,2024,14.
APA	Cai, Wen-Tao, Zeng, Xiu-Ya, Huang, Yun-Shi, Chen, Wei-Sheng, Chen, Xiang-Jian, & Xie, Xian-Hai. (2024). The clinical outcome of minor changes in serum creatinine for patients after curative gastrectomy: a prospective study. FRONTIERS IN ONCOLOGY, 14.
MLA	Cai, Wen-Tao,et al."The clinical outcome of minor changes in serum creatinine for patients after curative gastrectomy: a prospective study".FRONTIERS IN ONCOLOGY 14(2024).