Causal association between mitochondrial function and psychiatric disorders: Insights from a bidirectional two-sample Mendelian randomization study

doi:10.1016/j.jad.2024.09.039

科研成果详情

题名	Causal association between mitochondrial function and psychiatric disorders: Insights from a bidirectional two-sample Mendelian randomization study
作者	Lin, Yun-Lu1,2; Yao, Tao1,2; Wang, Ying-Wei1,2; Lu, Jia-Hao1,2; Chen, Yan-Min1,2; Wu, Yu-Qing1,2; Qian, Xin-Ge1,2; Liu, Jing-Chen1,2; Fang, Luo-Xiang1,2; Zheng, Cheng1,2; Wu, Chun-Hui3,4,5; Lin, Jia-Feng1,2
发表日期	2025
发表期刊	Journal of Affective Disorders 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Psychiatric disorders Mitochondria Mendelian randomization Single-nucleotide polymorphism
其他关键词	ASPARTATE/GLUTAMATE CARRIER SLC25A12 ; TRANSFER-RNA ; INSTRUMENTS ; IDENTIFICATION ; STRESS ; AUTISM ; RISK ; GENE ; BIAS
摘要	Background: Previous observational studies have suggested that there appears to be a close association between mitochondrial function and psychiatric disorders, but whether a causal role exists remains unclear. Methods: We extracted genetic instruments for 67 mitochondrial-related proteins and 10 psychiatric disorders from publicly available genome-wide association studies, and employed five distinct MR methods and false discovery rate correction to detect causal associations between them. Additionally, we conducted a series of sensitivity tests and additional model analysis to ensure the robustness of the results. For potential causal associations, we further performed reverse MR analyses to assess the impact of reverse causality. Results: We identified a total of 2 significant causal associations and 24 suggestive causal associations. Specifically, Phenylalanine-tRNA ligase was found to increase the risk of Alzheimer's disease, while Mitochondrial glutamate carrier 2 decreased the risk of autism spectrum disorder. Furthermore, there was no evidence of significant pleiotropy, heterogeneity, or reverse causality. Limitations: This study was limited to individuals of European ancestry, and the conclusions drawn are merely revelatory. Conclusion: This study provides novel insights into the relationship between mitochondria and psychiatric disorders, as well as the pathogenesis and treatment strategies for psychiatric disorders.
资助项目	National Natural Science Foundation of China [82070333]; Zhejiang Provincial Natural Sci-ence Foundation [LY21H020011]; Wenzhou Munic-ipal Science and Technology Bureau [ZY2020018, Y2020698, Y20220472]
出版者	ELSEVIER
ISSN	0165-0327
EISSN	1573-2517
卷号	368 页码:55-66
DOI	10.1016/j.jad.2024.09.039
页数	12
WOS类目	Clinical Neurology ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:001317637900001
收录类别	SCIE ; SCOPUS ; PUBMED ; SSCI
URL	查看原文
PubMed ID	39265869
SCOPUSEID	2-s2.0-85203661299
通讯作者地址	[Wu, Chun-Hui;Lin, Jia-Feng]109 Xueyuan Rd, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Clinical Psychology;Psychiatry and Mental Health
SCOPUS_ID	SCOPUS_ID:85203661299
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218739
专题	附属第二医院附属第二医院_儿童心血管科附属第一医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Wu, Chun-Hui; Lin, Jia-Feng
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Childrens Heart Ctr, Wenzhou 325027, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Yuying Childrens Hosp, Inst Cardiovasc Dev & Translat Med, Wenzhou 325027, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Ultrasonog, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Lin, Yun-Lu,Yao, Tao,Wang, Ying-Wei,et al. Causal association between mitochondrial function and psychiatric disorders: Insights from a bidirectional two-sample Mendelian randomization study[J]. Journal of Affective Disorders,2025,368:55-66.
APA	Lin, Yun-Lu., Yao, Tao., Wang, Ying-Wei., Lu, Jia-Hao., Chen, Yan-Min., ... & Lin, Jia-Feng. (2025). Causal association between mitochondrial function and psychiatric disorders: Insights from a bidirectional two-sample Mendelian randomization study. Journal of Affective Disorders, 368, 55-66.
MLA	Lin, Yun-Lu,et al."Causal association between mitochondrial function and psychiatric disorders: Insights from a bidirectional two-sample Mendelian randomization study".Journal of Affective Disorders 368(2025):55-66.