Correlation between ratio of fasting blood glucose to high density lipoprotein cholesterol in serum and non-alcoholic fatty liver disease in American adults: a population based analysis

doi:10.3389/fmed.2024.1428593

科研成果详情

题名	Correlation between ratio of fasting blood glucose to high density lipoprotein cholesterol in serum and non-alcoholic fatty liver disease in American adults: a population based analysis
作者	Jin, Xianjing 1; Xu, Jing2; Weng, Xiaochun 3
发表日期	2024-09-04
发表期刊	FRONTIERS IN MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	fasting blood glucose fatty liver obesity diabetes dyslipidemia
其他关键词	GLOBAL EPIDEMIOLOGY ; PREVALENCE ; STEATOHEPATITIS ; METABOLISM ; APOPTOSIS
摘要	Background: Based on previous research, elevated fasting blood glucose (FBG) and decreased high-density lipoprotein cholesterol (HDL-C) levels are associated with non-alcoholic fatty liver disease (NAFLD). It is hypothesized that the prevalence of NAFLD may be proportional to the FBG-to-HDL-C ratio (GHR). Methods: In this study, 3,842 participants from the National Health and Nutrition Examination Survey (NHANES) (2013-2020) were investigated. Liver steatosis was assessed using vibration-controlled transient elastography (VCTE). NAFLD was defined as controlled attenuation parameter (CAP) >= 288 dB/m. Results: After adjusting for race, gender, age, diabetes, BMI, moderate activities, uric acid, albumin, ALT, GGT, ALP, total bilirubin and creatinine, multiple logistic regression analysis indicated a positive correlation between GHR and the prevalence of NAFLD (OR = 1.22, 95% CI = 1.17-1.28). Additionally, multiple linear regression analysis showed a positive correlation between GHR and the severity of liver steatosis according to CA p-values (beta = 4.97, 95% CI: 4.28, 5.66). According to the subgroup analysis, the correlation was stronger in other race, participants at the age <50 years old and those with non-diabetes. In this study, a non-linear relationship and saturation effect between GHR and the prevalence of NAFLD was also revealed, characterized by an inverted L-shaped curve, with an inflection point of 7.443. Finally, the receiver operating characteristic (ROC) analysis suggested that the area under the curve (AUC) of GHR (AUC = 0.731) significantly exceeded that of FBG and HDL-C. Conclusion: Elevated GHR levels are independently associated with the severity of liver steatosis and the increased prevalence of NAFLD in American adults.
出版者	FRONTIERS MEDIA SA
ISSN	2296-858X
EISSN	2296-858X
卷号	11
DOI	10.3389/fmed.2024.1428593
页数	8
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:001315387900001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39296907
通讯作者地址	[Weng, Xiaochun]Wenzhou Med Univ, Affiliated Hosp 2, Dept Ultrasound, Yuying Childrens Hosp, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218725
专题	附属第二医院附属第二医院_内分泌科第二临床医学院、附属第二医院、育英儿童医院附属第二医院_超声影像科
通讯作者	Weng, Xiaochun
作者单位	1.Wenzhou Yongjia Cty Tradit Chinese Med Hosp, Dept Ultrasound, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 2, Dept Endocrinol, Yuying Childrens Hosp, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Ultrasound, Yuying Childrens Hosp, Wenzhou, Peoples R China
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 超声影像科
推荐引用方式 GB/T 7714	Jin, Xianjing,Xu, Jing,Weng, Xiaochun. Correlation between ratio of fasting blood glucose to high density lipoprotein cholesterol in serum and non-alcoholic fatty liver disease in American adults: a population based analysis[J]. FRONTIERS IN MEDICINE,2024,11.
APA	Jin, Xianjing, Xu, Jing, & Weng, Xiaochun. (2024). Correlation between ratio of fasting blood glucose to high density lipoprotein cholesterol in serum and non-alcoholic fatty liver disease in American adults: a population based analysis. FRONTIERS IN MEDICINE, 11.
MLA	Jin, Xianjing,et al."Correlation between ratio of fasting blood glucose to high density lipoprotein cholesterol in serum and non-alcoholic fatty liver disease in American adults: a population based analysis".FRONTIERS IN MEDICINE 11(2024).