题名 | Necessity of antiviral treatment for patients with chronic hepatitis B in the grey zone based on liver pathology analysis |
作者 | |
发表日期 | 2024-12-31 |
发表期刊 | ANNALS OF MEDICINE 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Chronic hepatitis B grey zone Ishak liver biopsy |
摘要 | Objective28-55% of chronic hepatitis B (CHB) patients belong to the grey zone (GZ). By analyzing the pathological characteristics of the liver of patients in the GZ, this study clarified whether the patients in the GZ need anti-hepatitis B virus treatment.MethodWe reviewed 324 cases of liver pathology that underwent liver biopsy between 2011 and 2022. According to the total score of inflammation G, 0-6 points are classified as mild, 7-12 points are classified as moderate, and 13-18 points are classified as severe. According to the total score of fibrosis F, 0-2 is mild, 3-4 is moderate, and 5-6 is severe. Significant histological diseases (SHD) are defined as the presence of inflammation G >= 6 and/or fibrosis F >= 2 in liver biopsy specimens.Result324 GZ patients were scored using the Ishak method, with G7-18 accounting for 9%, F3-6 accounting for 19.2%, and SHD accounting for 37%. The inflammation, fibrosis, and SHD in the HBeAg (+) group were more pronounced than those in the HBeAg (-) group. Among the GZ-A similar to GZ-D subgroups, the highest proportion of SHD in the GZ-B group was 58.35%.ConclusionMore than 1/3 of the patients in GZ need anti-hepatitis B virus treatment. More than half of GZ-B patients need anti-hepatitis B virus treatment. It is very necessary to carry out rescue anti-hepatitis B virus treatment for patients in GZ as soon as possible. |
资助项目 | Zhejiang Province Major Science and Technology Project for Medicine and Health [WKJ-ZJ-2329]; Public Welfare Science and Technology Project of Wenzhou [Y2020267] |
出版者 | TAYLOR & FRANCIS LTD |
ISSN | 0785-3890 |
EISSN | 1365-2060 |
卷号 | 56期号:1 |
DOI | 10.1080/07853890.2024.2399757 |
页数 | 9 |
WOS类目 | Medicine, General & Internal |
WOS研究方向 | General & Internal Medicine |
WOS记录号 | WOS:001313903100001 |
收录类别 | SCIE ; PUBMED |
URL | 查看原文 |
PubMed ID | 39283046 |
通讯作者地址 | [Huang, Yu]Wenzhou Med Univ, Affiliated Hosp 1, Dept Infect Dis, Wenzhou 325000, Peoples R China. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/218724 |
专题 | 附属第一医院 附属第一医院_肾内科 其他_附属舟山医院(舟山医院) |
通讯作者 | Huang, Yu |
作者单位 | 1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Nephrol, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Zhoushan Hosp, Dept Infect Dis, Zhoushan, Peoples R China; 3.Taizhou First Peoples Hosp, Dept Infect Dis, Taizhou, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Infect Dis, Wenzhou 325000, Peoples R China |
第一作者单位 | 附属第一医院; 肾内科 |
通讯作者单位 | 附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Zhang, Jianna,Yu, Sijie,Zhu, Kailu,et al. Necessity of antiviral treatment for patients with chronic hepatitis B in the grey zone based on liver pathology analysis[J]. ANNALS OF MEDICINE,2024,56(1). |
APA | Zhang, Jianna, Yu, Sijie, Zhu, Kailu, Li, Shibo, & Huang, Yu. (2024). Necessity of antiviral treatment for patients with chronic hepatitis B in the grey zone based on liver pathology analysis. ANNALS OF MEDICINE, 56(1). |
MLA | Zhang, Jianna,et al."Necessity of antiviral treatment for patients with chronic hepatitis B in the grey zone based on liver pathology analysis".ANNALS OF MEDICINE 56.1(2024). |
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