科研成果详情

题名Investigating how blood cadmium levels influence cardiovascular health scores across sexes and dose responses
作者
发表日期2024-08-21
发表期刊FRONTIERS IN PUBLIC HEALTH   影响因子和分区
语种英语
原始文献类型Article
关键词cadmium cardiovascular health sex factors risk factors NHANES
其他关键词GENDER-DIFFERENCES ; ALL-CAUSE ; MORTALITY ; ADULTS ; ASSOCIATIONS ; POLLUTION ; EXPOSURE ; DISEASES ; BURDEN ; TRENDS
摘要Background The association between exposure to cadmium (Cd) and cardiovascular health (CVH) has received considerable scientific interest. However, findings thus far have been inconclusive, particularly regarding sex-specific effects and dose-response relationships. The aim of our study was to investigate the relationships of blood Cd levels with the overall and component CVH scores.Methods We used data from the 2011-2018 NHANES to assess CVH using indicators such as BMI, blood pressure, lipid profiles, glucose levels, diet, physical activity, nicotine use, and sleep quality, each rated on a 0-100 scale. The overall CVH score was calculated as the average of these indicators. We employed both multiple linear and restricted cubic spline analyses to examine the relationship between blood Cd levels and CVH scores, including nonlinear patterns and subgroup-specific effects.Results Our analysis revealed that higher blood Cd levels were associated with lower overall CVH, nicotine exposure, sleep, and diet scores, with nonlinear decreases observed in overall CVH and nicotine exposure scores at specific thresholds (-1.447 and -1.752 log mu g/dL, respectively). Notably, sex differences were evident; females experienced more adverse effects of Cd on CVH and lipid scores, while in males, Cd exposure was positively correlated with BMI, a link not observed in females.Conclusion Our study highlights the complex interplay between blood Cd levels and various aspects of CVH, revealing significant dose-response relationships and sex disparities. These findings enhance our understanding of the biobehavioral mechanisms linking Cd exposure to cardiovascular risk.
出版者FRONTIERS MEDIA SA
EISSN2296-2565
卷号12
DOI10.3389/fpubh.2024.1427905
页数9
WOS类目Public, Environmental & Occupational Health
WOS研究方向Public, Environmental & Occupational Health
WOS记录号WOS:001303861400001
收录类别SCIE ; SSCI
PubMed ID39234072
通讯作者地址[Zhang, Yu;Chen, Shaohe]Wenzhou Peoples Hosp, Dept Child Healthcare, Wenzhou, Peoples R China.
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/218697
专题附属第二医院
附属第二医院_儿童心血管科
第二临床医学院、附属第二医院、育英儿童医院
其他_附属平阳医院(平阳县人民医院)
通讯作者Zhang, Yuansi; Chen, Shaohe
作者单位
1.Wenzhou Peoples Hosp, Dept Child Healthcare, Wenzhou, Peoples R China;
2.Wenzhou Med Univ, Affiliated Hosp 2, Childrens Heart Ctr, Wenzhou, Peoples R China;
3.Wenzhou Med Univ, Yuying Childrens Hosp, Inst Cardiovasc Dev & Translat Med, Wenzhou, Peoples R China;
4.Wenzhou Med Univ, Dept Gastroenterol, Pingyang Affiliated Hosp, Wenzhou, Peoples R China;
5.Wenzhou Yebo Proctol Hosp, Dept Tradit Chinese Med, Wenzhou, Peoples R China
第一作者单位附属第二医院;  第二临床医学院,附属第二医院、育英儿童医院;  儿童心血管科
推荐引用方式
GB/T 7714
Chen, Feng,Lin, Hao,Zhang, Yuansi,et al. Investigating how blood cadmium levels influence cardiovascular health scores across sexes and dose responses[J]. FRONTIERS IN PUBLIC HEALTH,2024,12.
APA Chen, Feng, Lin, Hao, Zhang, Yuansi, Zhang, Yu, & Chen, Shaohe. (2024). Investigating how blood cadmium levels influence cardiovascular health scores across sexes and dose responses. FRONTIERS IN PUBLIC HEALTH, 12.
MLA Chen, Feng,et al."Investigating how blood cadmium levels influence cardiovascular health scores across sexes and dose responses".FRONTIERS IN PUBLIC HEALTH 12(2024).

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