Effect of vascular compression and drug injection time on thrombolytic therapy: Numerical simulation and validation

doi:10.1016/j.jbiomech.2024.112283

科研成果详情

题名	Effect of vascular compression and drug injection time on thrombolytic therapy: Numerical simulation and validation
作者	Zhou, Hongming 1,2; Cheng, Hongyu 1; Lin, Boyuan 1; Li, Sisi3; Zhang, Xianglei 1
发表日期	2024-10
发表期刊	Journal of Biomechanics 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Numerical modeling Biofluid mechanics Venous thrombosis Vascular pressure level In vitro experiments
其他关键词	PREVENT POSTTHROMBOTIC SYNDROME ; STOCKINGS ; FLOW ; THROMBUS
摘要	Venous thromboembolism (VTE) has been occurring frequently in human society. There is an urgent need to study the influence of several factors on thrombolytic therapy, such as the effects of vascular pressure levels (VPL) and the drug injection time (DIT). Considering blood as a non-Newtonian fluid, valve as a hyperelastic material, and thrombus as a porous medium, a new numerical simulation model of biofluid mechanics incorporating fluid-solid coupling phenomena and biochemical substance reactions is established based on the N-S equations and the convection-diffusion reaction equations. Then, a unique in vitro experimental platform is established to verify the correctness of the constructed mathematical model. The results showed that vascular compression resulted in significant differences in blood flow status localized within the vessel. Vascular compression causes the blood boosting index to fluctuate and the valve displacement values are 135% and 158% greater than the lower VPL, respectively. At the same time, vascular compression weakened vortex intensity, accelerated material transport and response, and improved the treatment. Compared with low VPL, the therapeutic efficacy increased by 7% and 15%, respectively. In addition, when the dose of the drug is high, different injection times can increase the therapeutic effect to different degrees, with a maximum difference of 12%. Our in vitro experiments are similar to the results obtained by numerical simulation, which can verify the reliability of numerical simulation. The computational model proposed and the experimental platform designed in this study have the potential to assist in clinical medication prediction in different venous thromboembolism patients.
资助项目	Scientific Research Project of Zhejiang Provincial Department of Education [Y202351981]; Laboratory Open Project of Wenzhou University
出版者	ELSEVIER SCI LTD
ISSN	0021-9290
EISSN	1873-2380
卷号	175
DOI	10.1016/j.jbiomech.2024.112283
页数	8
WOS类目	Biophysics ; Engineering, Biomedical
WOS研究方向	Biophysics ; Engineering
WOS记录号	WOS:001307916700001
收录类别	SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号	20243616990942
EI主题词	Vortex flow
EI分类号	1106.2 ; 1106.3.1 ; 1201.2 ; 1301.1.2 ; 301 ; 301.1 ; 301.1.5
URL	查看原文
PubMed ID	3923245
SCOPUSEID	2-s2.0-85202802516
通讯作者地址	[Lin, Boyuan]Wenzhou Univ, Coll Mech & Elect Engn, Wenzhou 325035, Peoples R China.
Scopus学科分类	Biophysics;Biomedical Engineering;Orthopedics and Sports Medicine;Rehabilitation
SCOPUS_ID	SCOPUS_ID:85202802516
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218652
专题	附属第一医院附属第一医院_耳鼻咽喉科
通讯作者	Lin, Boyuan
作者单位	1.Wenzhou Univ, Coll Mech & Elect Engn, Wenzhou 325035, Peoples R China; 2.Wenzhou Vocat & Tech Coll, Wenzhou 325035, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Wenzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Hongming,Cheng, Hongyu,Lin, Boyuan,et al. Effect of vascular compression and drug injection time on thrombolytic therapy: Numerical simulation and validation[J]. Journal of Biomechanics,2024,175.
APA	Zhou, Hongming, Cheng, Hongyu, Lin, Boyuan, Li, Sisi, & Zhang, Xianglei. (2024). Effect of vascular compression and drug injection time on thrombolytic therapy: Numerical simulation and validation. Journal of Biomechanics, 175.
MLA	Zhou, Hongming,et al."Effect of vascular compression and drug injection time on thrombolytic therapy: Numerical simulation and validation".Journal of Biomechanics 175(2024).