Clinical evaluation of bispectral index-guided closed-loop infusion of propofol for preschool children: A multi-center randomized controlled study

doi:10.1002/ped4.12449

科研成果详情

题名	Clinical evaluation of bispectral index-guided closed-loop infusion of propofol for preschool children: A multi-center randomized controlled study
作者	Hua, Lei 1; Du, Bin 2; Zuo, Yunxia 2; Liu, Huacheng3,4,5,6; Zhang, Jianmin 1
发表日期	2024-08-27
发表期刊	PEDIATRIC INVESTIGATION 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Closed-loop Target-controlled infusion Bispectral index Preschool children
其他关键词	INTRAVENOUS ANESTHESIA ; REMIFENTANIL ; TITRATION ; SURGERY ; SYSTEM
摘要	Importance: The closed-loop infusion system can automatically adjust and maintain the depth of anesthesia by using the propofol target-controlled infusion (TCI) model under the feedback guidance of the bispectral index (BIS). Objective: To evaluate the safety and superiority of closed-loop TCI of propofol guided by BIS during maintenance of generalized intravenous anesthesia for preschool children. Methods: A total of 120 children aged 1-6 years were enrolled and were divided into a closed-loop feedback group (Group C) and an open-loop manual control group (Group O), with 60 participants in each group. For anesthesia maintenance, the propofol infusion rate was adjusted by the injection system under the guidance of BIS in Group C and was manually adjusted by anesthesiologists according to the BIS and clinical experience in Group O, to maintain a BIS level of 50. The time ratio of adequate anesthesia (40 <= BIS <= 60), light anesthesia (BIS > 60), and deep anesthesia (BIS < 40) were recorded. Results: A total of 119 patients (59 in Group C and 60 in Group O) were enrolled in the study. Group C demonstrated a higher time ratio of adequate anesthesia (P = 0.014) compared to Group O. The time ratio of light anesthesia and the global score was lower in Group C than in Group O (P = 0.010, P = 0.015, respectively). The frequency of adjustment per unit of time was higher in Group C for propofol (P < 0.001), while it was lower for remifentanil (P = 0.010). Interpretation: BIS-guided closed-loop infusion of propofol is safe and effective for preschool children. The depth of anesthesia is controlled more accurately and smoothly.
出版者	WILEY
ISSN	2096-3726
EISSN	2574-2272
DOI	10.1002/ped4.12449
页数	7
WOS类目	Pediatrics
WOS研究方向	Pediatrics
WOS记录号	WOS:001299829200001
收录类别	ESCI
通讯作者地址	[Zhang, Jianmin]Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Anesthesiol, Beijing 100045, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218648
专题	附属第二医院_麻醉科温州医科大学第二临床医学院，附属第二医院、育英儿童医院附属第二医院_麻醉重点学科实验室
通讯作者	Zhang, Jianmin
作者单位	1.Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Anesthesiol, Beijing 100045, Peoples R China; 2.Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu, Sichuan, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol & Perioperat Med, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Minist Educ, Key Lab Pediat Anesthesiol, Wenzhou, Zhejiang, Peoples R China; 6.Wenzhou Med Univ, Key Lab Anesthesiol Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Hua, Lei,Du, Bin,Zuo, Yunxia,et al. Clinical evaluation of bispectral index-guided closed-loop infusion of propofol for preschool children: A multi-center randomized controlled study[J]. PEDIATRIC INVESTIGATION,2024.
APA	Hua, Lei, Du, Bin, Zuo, Yunxia, Liu, Huacheng, & Zhang, Jianmin. (2024). Clinical evaluation of bispectral index-guided closed-loop infusion of propofol for preschool children: A multi-center randomized controlled study. PEDIATRIC INVESTIGATION.
MLA	Hua, Lei,et al."Clinical evaluation of bispectral index-guided closed-loop infusion of propofol for preschool children: A multi-center randomized controlled study".PEDIATRIC INVESTIGATION (2024).