Unraveling the role of bisphenol A in osteosarcoma biology: insights into prognosis and immune microenvironment modulation

doi:10.1007/s12672-024-01280-x

科研成果详情

题名	Unraveling the role of bisphenol A in osteosarcoma biology: insights into prognosis and immune microenvironment modulation
作者	Liao, Shiyao 1; Kang, Yao 2,3; Lv, Jun 2,3; Lin, Yichen 4; Zhao, Tingxiao 2,3; Yao, Longtao2,5,6; Zhou, Hong 1; Zhou, Kai 7
发表日期	2024-09-04
发表期刊	Discover Oncology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Bisphenol A Osteosarcoma Prognosis Immune microenvironment Single-cell sequencing
其他关键词	EXPOSURE ; EXPRESSION
摘要	BackgroundBisphenol A (BPA) is a common environmental pollutant, and its specific mechanisms in cancer development and its impact on the tumor immune microenvironment are not yet fully understood.MethodsTranscriptome data from osteosarcoma (OS) patients were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. BPA-related genes were identified through the Comparative Toxicogenomics Database (CTD), yielding 177 genes. Differentially expressed genes were analyzed using the GSE162454 dataset from the Tumor Immune Single Cell Hub 2 (TISCH2). We constructed the prognostic model using univariate Cox regression and LASSO analysis. The model was validated using the GSE16091 dataset. GO, KEGG, and GSEA analyses were performed to investigate the mechanisms of BPA-related genes.ResultsA total of 15 BPA-related genes were identified as differentially expressed in OS. Univariate Cox regression and LASSO analysis identified four key prognostic genes (FOLR1, MYC, ESRRA, VEGFA). The prognostic model exhibited strong predictive performance with area under the curve (AUC) values of 0.89, 0.6, and 0.79 for predicting 1-, 2-, and 3-year survival, respectively. External validation using the GSE16091 dataset confirmed the model's high accuracy with AUC values exceeding 0.88. Our results indicated that the prognosis of the high-risk population is generally poorer, which may be associated with alterations in the tumor immune microenvironment. In the high-risk group, immune cells showed predominantly low expression levels, while immune checkpoint genes were significantly overexpressed, along with markedly elevated tumor purity. These findings revealed a correlation between upregulation of BPA-related genes and formation of an immunosuppressive microenvironment, leading to unfavorable patient outcomes.ConclusionOur study highlighted the significant association of BPA with OS biology, particularly in its potential role in modulating the tumor immune microenvironment. We offered a fresh insight into the influence of BPA on cancer development, thus providing valuable insights for future clinical interventions and treatment strategies.
资助项目	Zhejiang Provincial Health Bureau Science Foundation of China [2022ky034]; Zhejiang Provincial Natural Science Foundation [LTGY24H060009]
出版者	SPRINGER
ISSN	2730-6011
EISSN	2730-6011
卷号	15 期号:1
DOI	10.1007/s12672-024-01280-x
页数	14
WOS类目	Oncology ; Endocrinology & Metabolism
WOS研究方向	Oncology ; Endocrinology & Metabolism
WOS记录号	WOS:001306497700004
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39230832
SCOPUSEID	2-s2.0-85203242423
通讯作者地址	[Zhou, Kai]Wenzhou Med Univ, Dept Orthopaed, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China.
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Oncology;Endocrinology;Endocrine and Autonomic Systems;Cancer Research
SCOPUS_ID	SCOPUS_ID:85203242423
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218625
专题	附属第一医院附属第一医院_骨科
通讯作者	Zhou, Kai
作者单位	1.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Plast & Reconstruct Surg,Dept Orthoped, Hangzhou, Zhejiang, Peoples R China; 2.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Canc Ctr,Dept Orthoped, Hangzhou, Zhejiang, Peoples R China; 3.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Lab Med, Hangzhou, Zhejiang, Peoples R China; 4.Chinese Med Univ, Clin Med Coll Zhejiang 2, Hangzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Postgrad Training Base Alliance, Wenzhou 325000, Zhejiang, Peoples R China; 6.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Sports Med, Hangzhou 310000, Zhejiang, Peoples R China; 7.Wenzhou Med Univ, Dept Orthopaed, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China
通讯作者单位	附属第一医院; 骨科
推荐引用方式 GB/T 7714	Liao, Shiyao,Kang, Yao,Lv, Jun,et al. Unraveling the role of bisphenol A in osteosarcoma biology: insights into prognosis and immune microenvironment modulation[J]. Discover Oncology,2024,15(1).
APA	Liao, Shiyao., Kang, Yao., Lv, Jun., Lin, Yichen., Zhao, Tingxiao., ... & Zhou, Kai. (2024). Unraveling the role of bisphenol A in osteosarcoma biology: insights into prognosis and immune microenvironment modulation. Discover Oncology, 15(1).
MLA	Liao, Shiyao,et al."Unraveling the role of bisphenol A in osteosarcoma biology: insights into prognosis and immune microenvironment modulation".Discover Oncology 15.1(2024).