Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases

doi:10.1002/smsc.202400236

科研成果详情

题名	Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases
作者	Chen, Qizhu1,2,3; Zheng, Zitian 4,5,6; Lin, Mian7; Guo, Zhengyu 1,2; Huang, Hongjie 4,5; Xue, Qingyun 6; Jiang, Shengdan 3; Wang, Jianquan 4,5; Wu, Aimin1,2
发表日期	2024-09-03
发表期刊	SMALL SCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	bone tissue engineering applications cartilage defects degenerative joint diseases intervertebral disc degenerations nanocomposite hydrogels osteoarthritis
其他关键词	INTERVERTEBRAL DISC DEGENERATION ; CONTROLLED DRUG-RELEASE ; MESENCHYMAL STEM-CELLS ; EXTRACELLULAR-MATRIX ; INJECTABLE HYDROGEL ; COMPOSITE HYDROGEL ; NUCLEUS PULPOSUS ; ANNULUS FIBROSUS ; THERMOSENSITIVE HYDROGEL ; REGENERATIVE MEDICINE
摘要	Degenerative joint diseases, as a global public health issue, impose significant burdens on patients' lives and substantial economic costs on society. Currently, the primary modalities include physical therapy, pharmaceutical intervention, and surgical procedures. None of these approaches can alter the course of this degenerative process. Due to their commendable biocompatibility, biodegradability, and heightened efficacy in drug delivery, hydrogels present themselves as a novel noninvasive remedy for degenerative joint ailments. However, the clinical application of hydrogels still faces some challenges, including the uncontrolled discharge of encapsulated medications, the absence of adequate mechanical reinforcement for destabilized joints, and adaptability to fluctuating microenvironments. Recently, nanocomposite hydrogels, formed by introducing nanomaterials into hydrogels by physical or chemical means, can improve the limitations of hydrogels and extend their potential for biological applications in degenerative joint diseases. In this study, the pathologic features of degenerative joint diseases and the multiple applications of different types of nanocomposite hydrogels in targeting these different pathologic features are briefly described. It also concludes with an outlook on the use of nanocomposite hydrogels in clinical settings and discusses their challenges and limitations. By combining various nanomaterials with hydrogels, multifunctional nanocomposite hydrogels are developed for treating degenerative joint diseases. In osteoarthritis, they provide lubrication and anti-inflammatory effects; in cartilage defect, they adhere to and repair damaged cartilage, promoting regeneration; in degenerative intervertebral disc, they offer mechanical support and recruit stem cells to facilitate nucleus pulposus regeneration.image (c) 2024 WILEY-VCH GmbH
资助项目	National Natural Science Foundation of China (NSFC) [82272555, 82072403, 82272571]; Non-profit Central Research Institute Fund of Beijing Hospital [BJ-2018-088]; Wenzhou Major Scientific and Technological Innovation Project [ZY2022010]
出版者	WILEY
ISSN	2688-4046
DOI	10.1002/smsc.202400236
页数	34
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001303619100001
收录类别	ESCI
通讯作者地址	[Wu, Aimin]Wenzhou Med Univ, Affiliated Hosp 2, Key Lab Orthopaed Zhejiang Prov, Dept Orthopaed,Key Lab Struct Malformat Children, Wenzhou 325000, Zhejiang, Peoples R China. ; [Wu, Aimin]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China. ; [Jiang, Shengdan]Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Clin Spine Ctr, Sch Med, Shanghai 200082, Peoples R China. ; [Wang, Jianquan]Peking Univ, Peking Univ Third Hosp, Inst Sports Med, Dept Sports Med, Beijing 100191, Peoples R China. ; [Wang, Jianquan]Minist Educ, Engn Res Ctr Sports Trauma Treatment Technol & De, Beijing Key Lab Sports Injuries, Beijing 100191, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218582
专题	附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第二医院_骨科重点学科实验室其他_温州市第三临床学院（温州市人民医院）其他_附属第三医院（瑞安市人民医院）
通讯作者	Jiang, Shengdan; Wang, Jianquan; Wu, Aimin
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Key Lab Orthopaed Zhejiang Prov, Dept Orthopaed,Key Lab Struct Malformat Children, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China; 3.Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Clin Spine Ctr, Sch Med, Shanghai 200082, Peoples R China; 4.Peking Univ, Peking Univ Third Hosp, Inst Sports Med, Dept Sports Med, Beijing 100191, Peoples R China; 5.Minist Educ, Engn Res Ctr Sports Trauma Treatment Technol & De, Beijing Key Lab Sports Injuries, Beijing 100191, Peoples R China; 6.Chinese Acad Med Sci, Inst Geriatr Med, Natl Ctr Gerontol, Dept Orthoped,Beijing Hosp, Beijing 100730, Peoples R China; 7.Wenzhou Med Univ, Affiliated Hosp 3, Dept Orthopaed Surg, 108 WanSong Rd, Wenzhou 325200, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 骨科重点学科实验室
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 骨科重点学科实验室
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Chen, Qizhu,Zheng, Zitian,Lin, Mian,et al. Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases[J]. SMALL SCIENCE,2024.
APA	Chen, Qizhu., Zheng, Zitian., Lin, Mian., Guo, Zhengyu., Huang, Hongjie., ... & Wu, Aimin. (2024). Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases. SMALL SCIENCE.
MLA	Chen, Qizhu,et al."Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases".SMALL SCIENCE (2024).