Fabrication of co-delivery liposomal formulation incorporating carmustine and cabazitaxel displays improved cytotoxic potential and induced apoptosis in ovarian cancer cells

doi:10.1080/09205063.2024.2387949

科研成果详情

题名	Fabrication of co-delivery liposomal formulation incorporating carmustine and cabazitaxel displays improved cytotoxic potential and induced apoptosis in ovarian cancer cells
作者	Jianming Gong; Renqian Feng; Xiaoqing Fu; Qi Lin; Bicheng Wu
发表日期	2024-08-29
发表期刊	Journal of biomaterials science. Polymer edition 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Ovarian cancer cabazitaxel carmustine combination therapy liposomes
其他关键词	POLYMERIC NANOCARRIERS ; COMBINATION ; CHEMOTHERAPY ; RESISTANT ; THERAPY
摘要	Ovarian cancer is the primary cause of death from cancer in female patients. The existing treatments for ovarian cancer are restricted and ineffective in achieving a cure for the disease. To address this issue, we provide a novel approach to treating ovarian cancer by utilizing a liposomal carrier that effectively delivers the chemotherapeutic drugs carmustine (BCNU) and cabazitaxel (CTX). Initially, the combined impact of BCNU and CTX was confirmed, revealing that this impact reaches its maximum at a ratio of 1:2 mol/mol (BCNU/CTX). After that, the BC-Lipo co-delivery system was developed, which has a high capability for loading drugs (97.48% ± 1.14 for BCNU, 86.29% ± 3.03 for CTX). This system also has a sustained release profile and a beneficial long-circulating feature. The accumulation of BC-Lipo in tumors was dramatically enhanced compared to the accumulation of the free drug. Furthermore, BC-Lipo demonstrated similar levels of cytotoxicity to free BCNU and CTX (BCNU/CTX) when tested on HeLa cells in an in vitro model. Biochemical staining methods investigated the cancer cell's morphological examination. The apoptosis was confirmed by FITC-Annexin-V/PI staining by flow cytometry analysis. In addition, the investigation of fluorescence and protein markers examined the apoptosis mechanistic pathway, and the results indicated that BC-Lipo induced apoptosis due to mitochondrial membrane potential variation. This proof-of-concept study has established the probability of these BCNU-CTX combined treatments as active drug delivery nanocarriers for poorly soluble BCNU and CTX
出版者	TAYLOR & FRANCIS LTD
ISSN	0920-5063
EISSN	1568-5624
DOI	10.1080/09205063.2024.2387949
页数	21
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials ; Polymer Science
WOS研究方向	Engineering ; Materials Science ; Polymer Science
WOS记录号	WOS:001300324700001
收录类别	PUBMED ; SCIE ; EI
EI入藏号	20243616986065
EI主题词	Computerized tomography
EI分类号	102.1.1 ; 102.1.2 ; 102.2.1 ; 103 ; 1106.5 ; 746 Imaging Techniques ; 941.2 Acoustic Variables Measurements
URL	查看原文
PubMed ID	39207251
通讯作者地址	[Gong, Jianming]3 Fuxue Xiang, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217687
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
作者单位	Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
第一作者单位	附属第一医院; 妇产科学; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Jianming Gong,Renqian Feng,Xiaoqing Fu,et al. Fabrication of co-delivery liposomal formulation incorporating carmustine and cabazitaxel displays improved cytotoxic potential and induced apoptosis in ovarian cancer cells[J]. Journal of biomaterials science. Polymer edition,2024.
APA	Jianming Gong, Renqian Feng, Xiaoqing Fu, Qi Lin, & Bicheng Wu. (2024). Fabrication of co-delivery liposomal formulation incorporating carmustine and cabazitaxel displays improved cytotoxic potential and induced apoptosis in ovarian cancer cells. Journal of biomaterials science. Polymer edition.
MLA	Jianming Gong,et al."Fabrication of co-delivery liposomal formulation incorporating carmustine and cabazitaxel displays improved cytotoxic potential and induced apoptosis in ovarian cancer cells".Journal of biomaterials science. Polymer edition (2024).