Decreased Serum CTRP3 level was associated with connective tissue diseases

doi:10.1016/j.heliyon.2024.e36322

科研成果详情

题名	Decreased Serum CTRP3 level was associated with connective tissue diseases
作者	Ma, Lisha 1; Lin, Jiangbo 3; Shao, Miaoli 1; Chen, Binxuan 1; Zhou, Renfang 1; Shi, Jianfeng 2
发表日期	2024-08-30
发表期刊	Heliyon; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Connective tissue diseases CTRP3 CTRP9 RA SLE
其他关键词	CLASSIFICATION CRITERIA ; SJOGRENS-SYNDROME ; ARTHRITIS
摘要	Objective: Complement C1q tumor necrosis factor-related protein 3 (CTRP3) and 9 (CTRP9) are two of the most extensively studied adipokines, known for their diverse biological functions. However, it remains unclear whether serum levels of CTRP3 or CTRP9 are associated with connective tissue diseases (CTD). Methods: Serum CTRP3 and CTRP9 levels were measured by enzyme-linked immune sorbent assay (ELISA) and analyzed in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary Sjogren's syndrome (pSS), ankylosing spondylitis (AS), undifferentiated connective tissue disease (UCTD), as well as in healthy controls (HCs). Results: Serum CTRP3 levels were all significantly lower in patients with RA, SLE, pSS and AS compared with HCs. However, there were no significant differences in serum CTRP9 levels between patients with RA, SLE, pSS, or AS and HCs. In pSS patients, CTRP3 showed a weak correlation with blood glucose, creatinine, and urine acid in pSS patients, while no correlations were observed between serum CTRP3 levels and clinical or laboratory indices in RA, SLE or AS patients. Stable associations between CTRP3 and RA, SLE, pSS and AS were evaluated using multivariate logistics regression analysis. Receiver operating characteristic (ROC) curves were plotted to evaluated CTRP3 as a marker for RA, SLE, pSS and AS, yielding area under curve (AUC) values of 0.691, 0.727, 0.658 and 0.694, respectively. Conclusion: Decreased serum CTRP3 levels were associated with RA, SLE, pSS and AS.
资助项目	National Natural Science Foundation of China [82300365]; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission [2020RC148, 2022ky1413]
出版者	CELL PRESS
ISSN	2405-8440
EISSN	2405-8440
卷号	10 期号:16
DOI	10.1016/j.heliyon.2024.e36322
页数	10
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001298958700001
收录类别	SCOPUS ; SCIE
URL	查看原文
PubMed ID	39253249
SCOPUSEID	2-s2.0-85201456753
通讯作者地址	[Shi, Jianfeng]State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Cancer Institute,Shanghai Jiao Tong University,Shanghai,200127,China
Scopus学科分类	Multidisciplinary
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217582
专题	第一临床医学院（信息与工程学院）、附属第一医院_临床检验诊断学附属台州医院其他_附属台州医院（浙江省台州医院）
通讯作者	Shi, Jianfeng
作者单位	1.Department of Clinical Laboratory,The First People's Hospital of Wenling,Affiliated to Wenzhou Medical University,Zhejiang Province,Taizhou,China; 2.State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Cancer Institute,Shanghai Jiao Tong University,Shanghai,200127,China; 3.Department of Cardiology,Taizhou Hospital,Affiliated to Wenzhou Medical University,Zhejiang Province,Taizhou,China
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Ma, Lisha,Lin, Jiangbo,Shao, Miaoli,et al. Decreased Serum CTRP3 level was associated with connective tissue diseases[J]. Heliyon;,2024,10(16).
APA	Ma, Lisha, Lin, Jiangbo, Shao, Miaoli, Chen, Binxuan, Zhou, Renfang, & Shi, Jianfeng. (2024). Decreased Serum CTRP3 level was associated with connective tissue diseases. Heliyon;, 10(16).
MLA	Ma, Lisha,et al."Decreased Serum CTRP3 level was associated with connective tissue diseases".Heliyon; 10.16(2024).