Neutrophil-lymphocyte ratio predict outcome of upper gastrointestinal bleeding in emergency

doi:10.3389/fmed.2024.1366715

科研成果详情

题名	Neutrophil-lymphocyte ratio predict outcome of upper gastrointestinal bleeding in emergency
作者	Chen, Xinyi1; Li, Xinqun1; Zhao, Guangju1; Xu, Wen2
发表日期	2024-08-08
发表期刊	FRONTIERS IN MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	upper gastrointestinal bleeding neutrophil-lymphocyte ratio outcome Glasgow-Blatchford score full Rockall score
其他关键词	MORTALITY ; INFLAMMATION ; ULCER
摘要	Background: The neutrophil-lymphocyte ratio (NLR) is a simple marker of systemic inflammatory responses. The present study aims to evaluate the prognostic significance of the NLR on admission day in predicting outcomes for patients with upper gastrointestinal bleeding (UGIB), which is a prevalent medical emergency. Methods: 726 patients who were admitted to our clinic between January 2019 and December 2022 diagnosed with UGIB, and who underwent necessary examinations, were included in the study. The patients' Glasgow-Blatchford Score (GBS), Full Rockall Score (FRS), and NLR levels were calculated at the first admission. Outcomes were defined as in-hospital mortality, need for blood transfusion, surgical treatment and endoscopic therapy. Patients were categorized into four groups using NLR quartile levels to compare their clinical characteristics, Glasgow Blatchford Score, Full Rockall Score levels, and prognosis. Secondary, we modified FRS and GBS by adding NLR, respectively. We used area under the receiver operating characteristic curve (AUROC) to assess the accuracy of risk prediction for NLR, NLR-GBS, and NLR-FRS improved models. Results: Of 726 patients, 6% died in hospital, 23.9% received endoscopic interventon, 4.8% received surgical treatment, and 46.4% received transfusion therapy. Multifactorial logistic regression showed that a high level of NLR was a risk factor for death in patients with UGIB (p = 0.028). NLR, GBS, FRS, NLR-GBS, and NLR-FRS have sufficient accuracy in predicting inpatient mortality, endoscopic treatment, and transfusion treatment, and the differences are statistically significant (p < 0.05). In the comprehensive prediction of adverse outcomes, NLR-GBS has the highest AUROC, and in predicting inpatient mortality, NLR-FRS has the highest AUROC. Conclusion: For UGIB patients, a high NLR was strongly associated with high risk UGIB. Combined testing with the GBS and FRS can achieve good predictive results, which is valuable in guiding the pre-screening and triage of emergency nursing care and clinical treatment to ensure that patients receive rapid and effective treatment and improve the quality of care.
资助项目	Wenzhou Association of Science and Technology Service Innovation Project [kjfw23]
出版者	FRONTIERS MEDIA SA
ISSN	2296-858X
EISSN	2296-858X
卷号	11
DOI	10.3389/fmed.2024.1366715
页数	9
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:001295837400001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39175815
通讯作者地址	[Li, Xinqun]Wenzhou Med Univ, Dept Emergency, Affiliated Hosp 1, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217479
专题	附属第一医院基础医学院（机能实验教学中心）附属第一医院_急诊科
通讯作者	Li, Xinqun
作者单位	1.Wenzhou Med Univ, Dept Emergency, Affiliated Hosp 1, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Sch Basic Med Sci, Wenzhou, Peoples R China
第一作者单位	附属第一医院; 急诊科
通讯作者单位	附属第一医院; 急诊科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Xinyi,Li, Xinqun,Zhao, Guangju,et al. Neutrophil-lymphocyte ratio predict outcome of upper gastrointestinal bleeding in emergency[J]. FRONTIERS IN MEDICINE,2024,11.
APA	Chen, Xinyi, Li, Xinqun, Zhao, Guangju, & Xu, Wen. (2024). Neutrophil-lymphocyte ratio predict outcome of upper gastrointestinal bleeding in emergency. FRONTIERS IN MEDICINE, 11.
MLA	Chen, Xinyi,et al."Neutrophil-lymphocyte ratio predict outcome of upper gastrointestinal bleeding in emergency".FRONTIERS IN MEDICINE 11(2024).