Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway

doi:10.1080/13510002.2024.2392329

科研成果详情

题名	Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway
作者	Lin, Zhihui1,2; Wu, Chang1,2; Song, Dongyan1,2; Zhu, Chenxi1,2; Wu, Bosen1,2; Wang, Jie 2,3; Xue, Yangjing1,2
发表日期	2024-12-31
发表期刊	REDOX REPORT 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Sarmentosin Doxorubicin cardiotoxicity autophagy ferroptosis
其他关键词	CELL-DEATH ; AUTOPHAGY ; PROTECTS
摘要	Doxorubicin (Dox) is extensively used as an antitumor agent, but its severe cardiotoxicity significantly limits its clinical use. Current treatments for Dox-induced cardiotoxicity are inadequate, necessitating alternative solutions. This study evaluated the effects of sarmentosin, a compound from Sedum sarmentosum, on Dox-induced cardiotoxicity and dysfunction. Sarmentosin was administered as a pretreatment to both mice and H9c2 cells before Dox exposure. Subsequently, markers of Dox-induced cardiotoxicity and ferroptosis in serum and cell supernatants were measured. Western blot analysis was utilized to detect levels of ferroptosis, oxidative stress, and autophagy proteins. Additionally, echocardiography, hematoxylin-eosin staining, ROS detection, and immunofluorescence techniques were employed to support our findings. Results demonstrated that sarmentosin significantly inhibited iron accumulation, lipid peroxidation, and oxidative stress, thereby reducing Dox-induced ferroptosis and cardiotoxicity in C57BL/6 mice and H9c2 cells. The mechanism involved the activation of autophagy and the Nrf2 signaling pathway. These findings suggest that sarmentosin may prevent Dox-induced cardiotoxicity by mitigating ferroptosis. The study underscores the potential of compounds like sarmentosin in treating Dox-induced cardiotoxicity.
资助项目	Major Science and Technology Special Project of Wenzhou [2018ZY018]
出版者	TAYLOR & FRANCIS LTD
ISSN	1351-0002
EISSN	1743-2928
卷号	29 期号:1
DOI	10.1080/13510002.2024.2392329
页数	12
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
WOS记录号	WOS:001292964800001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39150892
通讯作者地址	[Xue, Yangjing]Wenzhou Med Univ, Affiliated Hosp 2, Dept Cardiol, Wenzhou 325000, Zhejiang, Peoples R China. ; [Wang, Jie;Xue, Yangjing]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China. ; [Wang, Jie]Wenzhou Med Univ, Affiliated Hosp 2, Dept Endocrinol, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217473
专题	附属第二医院附属第二医院_耳鼻咽喉科附属第二医院_内分泌科第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Wang, Jie; Xue, Yangjing
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Cardiol, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Endocrinol, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 耳鼻咽喉科
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 耳鼻咽喉科; 内分泌科
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Lin, Zhihui,Wu, Chang,Song, Dongyan,et al. Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway[J]. REDOX REPORT,2024,29(1).
APA	Lin, Zhihui., Wu, Chang., Song, Dongyan., Zhu, Chenxi., Wu, Bosen., ... & Xue, Yangjing. (2024). Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway. REDOX REPORT, 29(1).
MLA	Lin, Zhihui,et al."Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway".REDOX REPORT 29.1(2024).