Sustained-release of SOD from multivesicular liposomes accelerated the colonic mucosal healing of colitis mice by inhibiting oxidative stress

doi:10.1016/j.colsurfb.2024.114143

科研成果详情

题名	Sustained-release of SOD from multivesicular liposomes accelerated the colonic mucosal healing of colitis mice by inhibiting oxidative stress
作者	Ran, Kunjie1,2; Wang, Jie1,2; Li, Dingwei1,2; Jiang, Zhijiang1,2; Ding, Bingyu1,2; Yu, Fengnan1,2; Hu, Sunkuan3; Wang, Lifen 4; Sun, Wenwen5; Xu, Helin1,2
发表日期	2024-11
发表期刊	Colloids and Surfaces B: Biointerfaces 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Multivesicular liposome Sustained release Ulcerative colitis Oxidative stress Superoxide dismutase
其他关键词	ULCERATIVE-COLITIS ; DELIVERY
摘要	Oxidative stress has long been known as a pathogenic factor of ulcerative colitis. Superoxide dismutase (SOD) has been demonstrated to mitigate gut mucosal injury via combating oxidative stress. Herein, we developed SODloaded multivesicular liposomes (S-MVLs) as sustained-release depot for ulcerative colitis treatment. S-MVLs were spherical honeycomb-like particles with average particle size of 27.3 +/- 5.4 mu m and encapsulating efficiency of 78.7 +/- 2.6 %. Moreover, the two-phase release profiles of SOD from S-MVLs were exhibited, that was, the burst release phase within 4 h and the sustained-release phase within 96 h. After intraperitoneally injecting SMVLs, in situ retention time of SOD at bowel cavity extended by 4-fold in comparison with SOD solution. In vitro cells experiment showed that S-MVLs had the protective effect on LPS-treated RAW 264.7 cells via scavenging ROS and inhibiting pro-inflammatory cytokines production. S-MVLs ameliorated the body weight loss, DAI score and the colon shortening of colitis mice. Meanwhile, the colonic morphology and the epithelial barrier of colitis mice were effectively recovered after S-MVLs treatment. The therapeutic mechanism might be associated with polymerizing M1 macrophages to M2 phenotypes and alleviating oxidative stress. Collectively, multivesicular liposomes might be a promising sustained-release depot of SOD for ulcerative colitis treatments.
资助项目	Wenzhou Scientific and Technolog-ical innovation project [ZY2022025]; Ningbo Science and Technology Bureau [2022J047]; Zhejiang Provincial Foun-dation for Health Department [2024KY1236]; Wenzhou Sci-ence and Technology Bureau [2023HZSY0012]; Hainan Provincial Natural Science Foundation Youth Fund [824QN260]; Scientific Research Center of Wenzhou Medical University
出版者	ELSEVIER
ISSN	0927-7765
EISSN	1873-4367
卷号	243
DOI	10.1016/j.colsurfb.2024.114143
页数	14
WOS类目	Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS研究方向	Biophysics ; Chemistry ; Materials Science
WOS记录号	WOS:001294568300001
收录类别	SCIE ; SCOPUS ; PUBMED ; EI
EI入藏号	20243316869000
EI主题词	Superoxide dismutase
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 815.1 Polymeric Materials
URL	查看原文
PubMed ID	39128435
SCOPUSEID	2-s2.0-85200890726
通讯作者地址	[Xu, Helin]Wenzhou Med Univ, Sch Pharmaceut Sci, Dept pharmaceut, Wenzhou 325035, Zhejiang, Peoples R China. ; [Wang, Lifen]Hainan Med Univ, Res Ctr Drug Safety Evaluat, Haikou, Hainan, Peoples R China. ; [Sun, Wenwen]Wenzhou Med Univ, Affiliated Hosp 1, Pathol Dept, Wenzhou 325035, Zhejiang, Peoples R China.
Scopus学科分类	Biotechnology;Surfaces and Interfaces;Physical and Theoretical Chemistry;Colloid and Surface Chemistry
SCOPUS_ID	SCOPUS_ID:85200890726
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217454
专题	药学院（分析测试中心）附属第一医院附属第一医院_病理科药学院（分析测试中心）_药学系附属第一医院_消化内科其他_温州医科大学慈溪生物医药研究院
通讯作者	Wang, Lifen; Sun, Wenwen; Xu, Helin
作者单位	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Dept pharmaceut, Wenzhou 325035, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Cixi Biomed Res Inst, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou 325000, Zhejiang, Peoples R China; 4.Hainan Med Univ, Res Ctr Drug Safety Evaluat, Haikou, Hainan, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Pathol Dept, Wenzhou 325035, Zhejiang, Peoples R China
第一作者单位	药学院（分析测试中心）; 药学系; 温州医科大学慈溪生物医药研究院
通讯作者单位	药学院（分析测试中心）; 药学系; 附属第一医院; 病理科
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Ran, Kunjie,Wang, Jie,Li, Dingwei,et al. Sustained-release of SOD from multivesicular liposomes accelerated the colonic mucosal healing of colitis mice by inhibiting oxidative stress[J]. Colloids and Surfaces B: Biointerfaces,2024,243.
APA	Ran, Kunjie., Wang, Jie., Li, Dingwei., Jiang, Zhijiang., Ding, Bingyu., ... & Xu, Helin. (2024). Sustained-release of SOD from multivesicular liposomes accelerated the colonic mucosal healing of colitis mice by inhibiting oxidative stress. Colloids and Surfaces B: Biointerfaces, 243.
MLA	Ran, Kunjie,et al."Sustained-release of SOD from multivesicular liposomes accelerated the colonic mucosal healing of colitis mice by inhibiting oxidative stress".Colloids and Surfaces B: Biointerfaces 243(2024).