Development and application of a mechanical arm-based in situ 3D bioprinting method for the repair of skin wounds

doi:10.1007/s42452-024-06043-5

科研成果详情

题名	Development and application of a mechanical arm-based in situ 3D bioprinting method for the repair of skin wounds
作者	Zhou, Xue 1,2; Luo, Yichen 1,2; Gao, Yuanzhong 1,2; Ma, Jien 3; Lin, Cai4; Zhou, Xuhui 1,2; Li, Qi 1,2; Yang, Huayong 1,2; Zhang, Bin 1,2
发表日期	2024-08-12
发表期刊	DISCOVER APPLIED SCIENCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Wound repair In situ 3D bioprinting Mechanical arm control
其他关键词	SCAFFOLDS ; TISSUE ; EPIDEMIOLOGY ; BURNS
摘要	Current treatments for skin wounds typically involve multiple surgical procedures that require complex processes and expensive costs, making it difficult to achieve timely treatment in field environments. We developed an innovative in situ printing method, utilizing robotic arm control, to address the significant challenges of large-scale skin wound repair resulting from natural disasters such as earthquakes, fires, and explosions during relief efforts. Our portable 3D printing equipment, which integrates debridement, precise 3D scanning and modeling of wounds, and compatibility with cell-loaded bioink, facilitates rapid repair of large-area skin wounds in specialized field environments. Compared with traditional methods, this in situ printing method has significant advantages, including the ability to customize treatment according to the unique needs of the wound, achieve rapid healing, and the potential to reduce the total cost. We conducted experiments on rats with full-thickness dorsal skin defects and compared the performance of in situ bioprinting method with commercial skin defect repair dressings. Our results demonstrate that the in situ bioprinted skin achieved faster wound healing and more uniform re-epithelialization than the commercial dressing treatment. This study demonstrates the potential of in situ bioprinting method as a promising and effective strategy for rapid skin wound healing, especially for patients in remote environments where traditional wound treatment methods may not be readily available or practical. The development of a portable 3D skin printer that can operate in harsh field environments and meet the customized needs of individuals quickly.The printer utilizes the flexibility of a mechanical arm, providing a larger printing area and smaller size that can be easily collapsed into a suitcase-sized package when not in use.The portable printer offers significant advantages over traditional skin injury treatment methods, contributing to expedited skin wound recovery.
资助项目	Key Science and Technology Program of Zhejiang Province
出版者	SPRINGER
ISSN	3004-9261
EISSN	3004-9261
卷号	6 期号:8
DOI	10.1007/s42452-024-06043-5
页数	16
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001294076200001
收录类别	ESCI ; SCOPUS ; EI
EI入藏号	20243416898813
EI主题词	Robotic arms
EI分类号	101.1 ; 101.2.1 ; 101.6.1 ; 102.1.2.1 ; 1501.2.1 ; 1502.1 ; 731.5 Robotics ; 745.1 Printing ; 745.1.1 Printing Equipment ; 746 Imaging Techniques ; 802.2 Chemical Reactions ; 914 Safety Engineering
URL	查看原文
SCOPUSEID	2-s2.0-85201281819
通讯作者地址	[Zhang, Bin]Zhejiang Univ, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310058, Peoples R China. ; [Zhang, Bin]Zhejiang Univ, Sch Mech Engn, Hangzhou 310058, Peoples R China.
Scopus学科分类	Chemical Engineering (all);Earth and Planetary Sciences (all);Engineering (all);Environmental Science (all);Materials Science (all);Physics and Astronomy (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217374
专题	附属第一医院附属第一医院_烧伤科
通讯作者	Zhang, Bin
作者单位	1.Zhejiang Univ, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310058, Peoples R China; 2.Zhejiang Univ, Sch Mech Engn, Hangzhou 310058, Peoples R China; 3.Zhejiang Univ, Coll Elect Engn, Hangzhou 310058, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Burn, Wenzhou 325000, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Xue,Luo, Yichen,Gao, Yuanzhong,et al. Development and application of a mechanical arm-based in situ 3D bioprinting method for the repair of skin wounds[J]. DISCOVER APPLIED SCIENCES,2024,6(8).
APA	Zhou, Xue., Luo, Yichen., Gao, Yuanzhong., Ma, Jien., Lin, Cai., ... & Zhang, Bin. (2024). Development and application of a mechanical arm-based in situ 3D bioprinting method for the repair of skin wounds. DISCOVER APPLIED SCIENCES, 6(8).
MLA	Zhou, Xue,et al."Development and application of a mechanical arm-based in situ 3D bioprinting method for the repair of skin wounds".DISCOVER APPLIED SCIENCES 6.8(2024).