Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy

doi:10.1186/s12951-024-02778-w

科研成果详情

题名	Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy
作者	Zhang, Qingfei 1,2; Kuang, Gaizhen1,2; Wang, Li 2; Fan, Lu 2; Zhou, Yechao1; Shang, Luoran 4,5; Zhao, Yuanjin 1,3; Sun, Weijian1
发表日期	2024-08-20
发表期刊	Journal of Nanobiotechnology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Microfluidics Compartmental microparticle Biorthogonal chemistry Chemotherapy Photothermal therapy
摘要	Microcarrier is a promising drug delivery system demonstrating significant value in treating cancers. One of the main goals is to devise microcarriers with ingenious structures and functions to achieve better therapeutic efficacy in tumors. Here, inspired by the nucleus-cytoplasm structure of cells and the material exchange reaction between them, we develop a type of biorthogonal compartmental microparticles (BCMs) from microfluidics that can separately load and sequentially release cyclooctene-modified doxorubicin prodrug (TCO-DOX) and tetrazine-modified indocyanine green (Tz-ICG) for tumor therapy. The Tz-ICG works not only as an activator for TCO-DOX but also as a photothermal agent, allowing for the combination of bioorthogonal chemotherapy and photothermal therapy (PTT). Besides, the modification of DOX with cyclooctene significantly decreases the systemic toxicity of DOX. As a result, the developed BCMs demonstrate efficient in vitro tumor cell eradication and exhibit notable tumor growth inhibition with favorable safety. These findings illustrate that the formulated BCMs establish a platform for bioorthogonal prodrug activation and localized delivery, holding significant potential for cancer therapy and related applications.
资助项目	National Natural Science Foundation of China
出版者	BMC
ISSN	1477-3155
EISSN	1477-3155
卷号	22 期号:1
DOI	10.1186/s12951-024-02778-w
页数	12
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号	WOS:001294484200004
收录类别	SCIE ; SCOPUS ; PUBMED ; EI
EI入藏号	20243416921552
EI主题词	Chemotherapy
EI分类号	102.1.1 ; 102.1.2.1 ; 102.2.1
URL	查看原文
PubMed ID	39164657
SCOPUSEID	2-s2.0-85201713155
通讯作者地址	[Zhao, Yuanjin;Sun, Weijian]Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Wenzhou 325035, Peoples R China. ; [Zhao, Yuanjin]Southeast Univ, Nanjing Drum Tower Hosp, Sch Biol Sci & Med Engn, Dept Rheumatol & Immunol, Nanjing 210096, Peoples R China. ; [Shang, Luoran]Fudan Univ, Shanghai Xuhui Cent Hosp, Zhongshan Xuhui Hosp, Shanghai 200032, Peoples R China. ; [Shang, Luoran]Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Shanghai 200032, Peoples R China.
Scopus学科分类	Bioengineering;Medicine (miscellaneous);Molecular Medicine;Biomedical Engineering;Applied Microbiology and Biotechnology;Pharmaceutical Science
SCOPUS_ID	SCOPUS_ID:85201713155
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217323
专题	附属第一医院附属第一医院_胃肠外科
通讯作者	Shang, Luoran; Zhao, Yuanjin; Sun, Weijian
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Wenzhou 325035, Peoples R China; 2.Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325001, Peoples R China; 3.Southeast Univ, Nanjing Drum Tower Hosp, Sch Biol Sci & Med Engn, Dept Rheumatol & Immunol, Nanjing 210096, Peoples R China; 4.Fudan Univ, Shanghai Xuhui Cent Hosp, Zhongshan Xuhui Hosp, Shanghai 200032, Peoples R China; 5.Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Shanghai 200032, Peoples R China
第一作者单位	附属第一医院; 胃肠外科
通讯作者单位	附属第一医院; 胃肠外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Qingfei,Kuang, Gaizhen,Wang, Li,et al. Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy[J]. Journal of Nanobiotechnology,2024,22(1).
APA	Zhang, Qingfei., Kuang, Gaizhen., Wang, Li., Fan, Lu., Zhou, Yechao., ... & Sun, Weijian. (2024). Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy. Journal of Nanobiotechnology, 22(1).
MLA	Zhang, Qingfei,et al."Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy".Journal of Nanobiotechnology 22.1(2024).