Identification of inflammatory response-related molecular mechanisms based on the ATM/ATR/p53 pathway in tumor cells

doi:10.1016/j.compbiomed.2024.108776

科研成果详情

题名	Identification of inflammatory response-related molecular mechanisms based on the ATM/ATR/p53 pathway in tumor cells
作者	Chengye Li1; Hanbin Chen 2; Xiaojian Chen3; Peizhen Wang4; Yunjiao Shi2; Xiaona Xie 2; Yanfan Chen1; Xueding Cai5
发表日期	2024-07-31
发表期刊	Computers in Biology and Medicine 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	ATM/ATR/p53 pathway Cancer Cell apoptosis DNA damage ROS inflammation
摘要	Inflammatory response is a crucial factor that affects prognosis and therapeutic effect in tumor cells. Although some studies have shown that inflammation could make DNA more vulnerable to external attacks, resulting in serious DNA damage, the underlying mechanism remains unknown. Then, using tumor necrosis factor α (TNF-α) and lipopolysaccharide (LPS), this research elevated the level of inflammation in cancer cells, and hydrogen peroxide (H2O2) and ultraviolet (UV) were utilized as common reactive oxygen species (ROS)-induced DNA damage agents. We show that either H2O2 or UV achieved a more substantial antiproliferative effect in the inflammation environment compared with H2O2 or UV treatment alone. The inflammation environment enhanced H2O2- or UV-induced cell apoptosis and ROS production. Although the phenomenon that inflammation itself could trigger ROS-dependent DNA damage was well known, the underlying mechanism for the sensitization of inflammation to trigger intense DNA damage via ROS in cancer cells remains unclear. In this study, the inflammation-related genes and the corresponding expression information were obtained from the TCGA and fetched genes associated with inflammatory factors. Screening of thirteen inflammatory-related, including ATM, and prognostic genes. In addition, KEGG analysis of prognostic genes shows that biological processes such as DNA replication. ATM and ATR, which belong to the PI3/PI4-kinase family, can activate p53. Inflammation promotes the vulnerability of DNA by activating the ATM/ATR/p53 pathway, while not affecting the DNA damage repair pathway. In brief, this research suggested that inflammation made DNA vulnerable due to the amplifying H2O2- or UV-induced ROS production and the motoring ATM/ATR/p53 pathway. In addition, our findings revealed that inflammation's motoring of the ATM/ATR/p53 pathway plays a crucial role in DNA damage. Therefore, exploring the mechanism between inflammation and ROS-dependent DNA damage would be extremely valuable and innovative. This study would somewhat establish a better understanding of inflammation, DNA damage, and cancer
资助项目	National Natural Science Funding of China[82303105];National Natural Science Foundation of Zhejiang Province[LTGY23H160019];Wenzhou Municipal Science and Technology Bureau[Y2023102];
出版者	Elsevier Ltd
ISSN	0010-4825
EISSN	1879-0534
卷号	180
DOI	10.1016/j.compbiomed.2024.108776
收录类别	PUBMED ; SCOPUS ; EI
EI入藏号	20243216804116
EI主题词	Genes
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology
URL	查看原文
PubMed ID	39089116
SCOPUSEID	2-s2.0-85200111675
通讯作者地址	[Cai, Xueding]Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
Scopus学科分类	Health Informatics;Computer Science Applications
SCOPUS_ID	SCOPUS_ID:85200111675
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217096
专题	附属第一医院药学院（分析测试中心）第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_病理科附属第一医院_肿瘤内科
作者单位	1.Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.; 2.Department of Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.; 3.School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, People's Republic of China.; 4.Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.; 5.Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China. Electronic address: xueding514@126.com.
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chengye Li,Hanbin Chen,Xiaojian Chen,et al. Identification of inflammatory response-related molecular mechanisms based on the ATM/ATR/p53 pathway in tumor cells[J]. Computers in Biology and Medicine,2024,180.
APA	Chengye Li., Hanbin Chen., Xiaojian Chen., Peizhen Wang., Yunjiao Shi., ... & Xueding Cai. (2024). Identification of inflammatory response-related molecular mechanisms based on the ATM/ATR/p53 pathway in tumor cells. Computers in Biology and Medicine, 180.
MLA	Chengye Li,et al."Identification of inflammatory response-related molecular mechanisms based on the ATM/ATR/p53 pathway in tumor cells".Computers in Biology and Medicine 180(2024).