Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways

doi:10.1007/s10856-024-06811-0

科研成果详情

题名	Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways
作者	Cheng, Jing 1; Yu, Han 2; Zhang, Zhi-Feng 3; Jiang, Hong-Xiang 1; Wu, Ping 4; Wang, Zhou-Guang 4; Chen, Zhi-Biao 1; Wu, Li-Quan 1
发表日期	2024-12-01
发表期刊	Journal of Materials Science: Materials in Medicine 影响因子和分区
语种	英语
原始文献类型	Article
关键词	bpV (HOpic) ischemia-reperfusion injury M2 microglial polarization Mxene(Ti3C2Tx) PTEN
其他关键词	TUMOR-SUPPRESSOR ; NMDA RECEPTORS ; PTEN ; STROKE
摘要	Studies have shown that the inhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN)was neuroprotective against ischemia/reperfusion(I/R) injury. Bisperoxovanadium (bpV), a derivative of vanadate, is a well-established inhibitor of PTEN. However, its function islimited due to its general inadequacy in penetrating cell membranes. Mxene(Ti3C2Tx) is a novel two-dimensional lamellar nanomaterial with an excellent ability to penetrate the cell membrane. Yet, the effects of this nanomaterial on nervous system diseases have yet to be scrutinized. Here, Mxene(Ti3C2Tx) was used for the first time to carry bpV(HOpic), creating a new nanocomposite Mxene-bpV that was probed in a cerebral I/R injury model. The findings showed that this synthetic Mxene-bpV was adequately stable and can cross the cell membraneeasily. We observed that Mxene-bpV treatment significantly increased the survival rate of oxygen glucose deprivation/reperfusion(OGD/R)--insulted neurons, reduced infarct sizes and promoted the recovery of brain function after mice cerebral I/R injury. Crucially, Mxene-bpV treatment was more therapeutically efficient than bpV(HOpic) treatment alone over the same period. Mechanistically, Mxene-bpV inhibited the enzyme activity of PTEN in vitro and in vivo. It also promoted the expression of phospho-Akt (Ser473) by repressing PTEN and then activated the Akt pathway to boost cell survival. Additionally, in PTEN transgenic mice, Mxene-bpV suppressed I/R-induced inflammatory response by promoting M2 microglial polarization through PTEN inhibition. Collectively, the nanosynthetic Mxene-bpV inhibited PTEN’ enzymatic activity by activating Akt pathway and promoting M2 microglial polarization, and finally exerted neuroprotection against cerebral I/R injury. Graphical Abstract: (Figure presented.)
资助项目	NSFC[82201515];Natural Science Foundation of Hubei Province[2022CFB890];Natural Science Foundation of Hubei Provincial Department of Education[Q20212105];Hubei Province health and family planning scientific research project[WJ2023F076];
出版者	SPRINGER
ISSN	0957-4530
EISSN	1573-4838
卷号	35 期号:1
DOI	10.1007/s10856-024-06811-0
页数	17
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:001281440900007
收录类别	SCOPUS ; PUBMED ; SCIE ; EI
EI入藏号	20243116796427
EI主题词	Polarization
EI分类号	461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 761 Nanotechnology ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 933.1 Crystalline Solids
URL	查看原文
PubMed ID	39073469
SCOPUSEID	2-s2.0-85199936703
通讯作者地址	[Chen, Zhi-Biao]Department of Neurosurgery,Renmin Hospital of Wuhan University,99 Zhang Zhidong Street,Wuhan,430060,China ; [Wu, Li-Quan]Department of Neurosurgery,Renmin Hospital of Wuhan University,99 Zhang Zhidong Street,Wuhan,430060,China ; [Wang, Zhou-Guang]Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision,and Brain Health),School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Biophysics;Bioengineering;Biomaterials;Biomedical Engineering
SCOPUS_ID	SCOPUS_ID:85199936703
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216920
专题	药学院（分析测试中心）其他_瓯江实验室
通讯作者	Wang, Zhou-Guang; Chen, Zhi-Biao; Wu, Li-Quan
作者单位	1.Department of Neurosurgery,Renmin Hospital of Wuhan University,99 Zhang Zhidong Street,Wuhan,430060,China; 2.Department of Pathology,Xiangyang No.1 People’s Hospital,Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City,Department of Obstetrics and Gynaecology,Hubei Provincial Clinical Research Center for Accurate Fetus Malformation Diagnosis,Hubei University of Medicine,Xiangyang,441000,China; 3.Department of Physiology,School of Basic Medical Sciences,Hubei University of Medicine,Shiyan,442000,China; 4.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision,and Brain Health),School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325000,China
通讯作者单位	药学院（分析测试中心）; 瓯江实验室
推荐引用方式 GB/T 7714	Cheng, Jing,Yu, Han,Zhang, Zhi-Feng,et al. Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways[J]. Journal of Materials Science: Materials in Medicine,2024,35(1).
APA	Cheng, Jing., Yu, Han., Zhang, Zhi-Feng., Jiang, Hong-Xiang., Wu, Ping., ... & Wu, Li-Quan. (2024). Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways. Journal of Materials Science: Materials in Medicine, 35(1).
MLA	Cheng, Jing,et al."Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways".Journal of Materials Science: Materials in Medicine 35.1(2024).