Mechanical properties, corrosion behavior, and in vitro and in vivo biocompatibility of hot-extruded Zn-5RE (RE = Y, Ho, and Er) alloys for biodegradable bone-fixation applications

doi:10.1016/j.actbio.2024.07.006

科研成果详情

题名	Mechanical properties, corrosion behavior, and in vitro and in vivo biocompatibility of hot-extruded Zn-5RE (RE = Y, Ho, and Er) alloys for biodegradable bone-fixation applications
作者	Tong, Xian1,2; Miao, Daoyi 3; Zhou, Runqi 4; Shen, Xinkun3; Luo, Peng5; Ma, Jianfeng1; Li, Yuncang 6; Lin, Jixing1; Wen, Cuie 6; Sun, Xuecheng7
发表日期	2024
发表期刊	Acta Biomaterialia 影响因子和分区
语种	英语
原始文献类型	Article in Press
关键词	Binary alloys Biocompatibility Compressive strength Corrosion resistance Corrosion resistant alloys Corrosive effects Degradation Elongation Erbium alloys Gadolinium alloys Magnesium alloys Rare earths Tensile strength Yield stress Zinc alloys Biodegradable metals Bone fixation Compression properties In-vitro In-vivo Osteogenesis Osteogenic differentiation Osteogenic differentiation ability Tensile and compression property Zn-RE alloy
其他关键词	RARE-EARTH-ELEMENTS ; MAGNESIUM ALLOYS ; ANTIBACTERIAL ABILITY ; HIGH-STRENGTH ; ZN ; MICROSTRUCTURE ; CYTOTOXICITY ; PERFORMANCE ; TOXICITY ; IMPLANT
摘要	Biodegradable Zn alloys have significant application potential for hard-tissue implantation devices owing to their suitable degradation behavior and favorable biocompatibility. Nonetheless, pure Zn and its alloys in the as-cast state are mechanically instable and low in strength, which restricts their clinical applicability. Here, we report the exceptional mechanical, corrosion, and biocompatibility properties of hot-extruded Zn-5RE (wt.%, RE = rare earth of Y; or Ho; or Er) alloys intended for use in biodegradable bone substitutes. The microstructural characteristics, mechanical behavior, corrosion resistance, cytocompatibility, osteogenic differentiation, and capacity of osteogenesis in vivo of the Zn-5RE alloys are comparatively investigated. The Zn-5Y alloy demonstrates the best tensile properties, encompassing a 138 MPa tensile yield strength, a 302 MPa ultimate tensile strength, and 63% elongation, while the Zn-5Ho alloy shows the highest compression yield strength of 260 MPa and Vickers hardness of 104 HV. The Zn-5Er alloy shows a 126 MPa tensile yield strength, a 279 MPa ultimate tensile strength, 52% elongation, a 196 MPa compression yield strength, and a 101 HV Vickers microhardness. Further, the Zn-5Er alloy has a 130 µm per year corrosion rate in electrochemical tests and a 26 µm per year degradation rate in immersion tests, which is the lowest among the tested alloys. It also has the best in vitro osteogenic differentiation ability and capacity for osteogenesis and osteointegration in vivo after implantation in rat femurs among the Zn-5RE alloys, indicating promising potential in load-bearing biodegradable internal bone-fixation applications. Statement of significance: This work reports the exceptional mechanical, corrosion, and biocompatibility properties of hot-extruded (HE) Zn-5 wt.%–rare earth (Zn-5RE) alloys using single yttrium (Y), holmium (Ho), and erbium (Er) alloying for biodegradable bone-implant applications. Our findings demonstrate that the HE Zn-5Er alloy showed σuts of 279 MPa, tensile yield strength of 126 MPa, elongation of 51.6%, compression yield strength of 196 MPa, and microhardness of 101.2 HV. Further, HE Zn-5Er showed the lowest electrochemical corrosion rate of 130 µm/y and lowest degradation rate of 26 µm/y, and the highest in vitro osteogenic differentiation ability, in vivo osteogenesis, and osteointegration ability after implantation in rat femurs among the Zn-5RE alloys, indicating promising potential in load-bearing biodegradable internal bone-fixation applications. © 2024 The Author(s)
资助项目	Zhejiang Public Welfare Technology Application Research Project of China[LTGY24H140002,LGF22H140008];Australian Research Council[DP240101131];
出版者	Acta Materialia Inc
ISSN	1742-7061
EISSN	1878-7568
卷号	185 页码:55-72
DOI	10.1016/j.actbio.2024.07.006
页数	18
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:001309176300001
收录类别	EI ; SCOPUS ; PUBMED ; SCIE
EI入藏号	20243016742329
EI主题词	Corrosion rate
EI分类号	461.9.1 Immunology ; 531 Metallurgy and Metallography ; 539.1 Metals Corrosion ; 542.2 Magnesium and Alloys ; 546.3 Zinc and Alloys ; 547.2 Rare Earth Metals ; 549.2 Alkaline Earth Metals ; 802.2 Chemical Reactions ; 804.2 Inorganic Compounds ; 951 Materials Science
URL	查看原文
PubMed ID	38997078
SCOPUSEID	2-s2.0-85199045757
通讯作者地址	[Luo, Peng]Department of Orthopaedics,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Biotechnology;Biomaterials;Biochemistry;Biomedical Engineering;Molecular Biology
SCOPUS_ID	SCOPUS_ID:85199045757
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216902
专题	口腔医学院、附属口腔医院附属第二医院附属第一医院第二临床医学院，附属第二医院、育英儿童医院其他_附属第三医院（瑞安市人民医院）
通讯作者	Luo, Peng; Lin, Jixing; Wen, Cuie; Sun, Xuecheng
作者单位	1.Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou; 325000, China 2.School of Materials Science and Engineering, Xiangtan University, Xiangtan; 411105, China 3.Department of Orthopaedics, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital), Wenzhou; 325016, China 4.Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering, Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing; 401174, China 5.Department of Orthopaedics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou; 325000, China 6.Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne; VIC; 3001, Australia 7.Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou; 325000, China
第一作者单位	口腔医学院、附属口腔医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Tong, Xian,Miao, Daoyi,Zhou, Runqi,et al. Mechanical properties, corrosion behavior, and in vitro and in vivo biocompatibility of hot-extruded Zn-5RE (RE = Y, Ho, and Er) alloys for biodegradable bone-fixation applications[J]. Acta Biomaterialia,2024,185:55-72.
APA	Tong, Xian., Miao, Daoyi., Zhou, Runqi., Shen, Xinkun., Luo, Peng., ... & Sun, Xuecheng. (2024). Mechanical properties, corrosion behavior, and in vitro and in vivo biocompatibility of hot-extruded Zn-5RE (RE = Y, Ho, and Er) alloys for biodegradable bone-fixation applications. Acta Biomaterialia, 185, 55-72.
MLA	Tong, Xian,et al."Mechanical properties, corrosion behavior, and in vitro and in vivo biocompatibility of hot-extruded Zn-5RE (RE = Y, Ho, and Er) alloys for biodegradable bone-fixation applications".Acta Biomaterialia 185(2024):55-72.