科研成果详情

题名Escitalopram moderately outperforms citalopram towards anti-neuroinflammation and neuroprotection in 6-hydroxydopamine-in-duced mouse model of Parkinson's disease
作者
发表日期2024-09-30
发表期刊International Immunopharmacology   影响因子和分区
语种英语
原始文献类型Article
关键词Parkinson's disease Escitalopram Citalopram Neuroinflammation Neuroprotection
其他关键词ANTIDEPRESSANTS ; TOLERABILITY ; PAROXETINE ; EFFICACY ; VENLAFAXINE ; DEPRESSION ; SYMPTOMS ; MEMORY ; MICE ; SSRI
摘要Citalopram and escitalopram are structurally close-related antidepressants and both forms are widely used in the world. We aimed to comparatively evaluate the anti-neuroinflammatory and neuroprotective effects of escitalopram and citalopram in Parkinson's disease (PD) mouse model. Mice were randomly divided into six groups and received 6-hydroxydopamine (6-OHDA) or vehicle administration. The mice were then treated with escitalopram, citalopram or saline for consecutive 7 days. Behaviors, neuroinflammation, neurotransmitters, and neurotoxicity were assessed. Results showed that citalopram but not escitalopram worsened body weight loss and increased freezing time in the PD mice. Both drugs had no impact on the anxiety-like behaviors but ameliorated the depressive-like behaviors as in elevated plus maze and sucrose splash tests. Escitalopram but not citalopram ameliorated motor discoordination in the PD mice as in rotarod test. In accordance, escitalopram but not citalopram attenuated the 6-OHDA-induced nigrostriatal dopaminergic loss. Further mechanistic investigations showed that both drugs mitigated activations of microglia and astrocytes and/or levels of pro-inflammatory cytokines in the PD mice, but escitalopram showed appreciably better effects in the substantia nigra. Neurotransmitter examination in the prefrontal cortex suggested that the two drugs had comparable effects on the disturbed neurotransmitters in the PD mice, but citalopram was prone to disrupt certain normal homeostasis. In conclusion, escitalopram is moderately superior than citalopram to suppress neuroinflammation and to protect against dopaminergic neuronal death and motor discoordination in the 6-OHDA-induced PD mice. Our findings imply that escitalopram shall be prescribed with priority over citalopram to treat PD patients with depression as escitalopram may meanwhile provide greater additional benefits to the patients.
资助项目Zhejiang Pro-vincial Natural Science Foundation [LD19H090001]; National Nat-ural Science Foundation of China [82071585, 82271282]
出版者ELSEVIER
ISSN1567-5769
EISSN1878-1705
卷号139
DOI10.1016/j.intimp.2024.112715
页数12
WOS类目Immunology ; Pharmacology & Pharmacy
WOS研究方向Immunology ; Pharmacology & Pharmacy
WOS记录号WOS:001275765400001
收录类别SCIE ; SCOPUS ; PUBMED
URL查看原文
PubMed ID39032471
SCOPUSEID2-s2.0-85198994907
通讯作者地址[Zhang, Xiong]Wenzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Wenzhou 325027, Zhejiang, Peoples R China. ; [Zhang, Xiong]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China. ; [Zhu, Jian-Hong]Wenzhou Med Univ, Biomed Res Bldg B305 B307, Wenzhou 325035, Zhejiang, Peoples R China.
Scopus学科分类Immunology and Allergy;Immunology;Pharmacology
SCOPUS_IDSCOPUS_ID:85198994907
TOP期刊TOP期刊
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/216845
专题公共卫生学院_预防医学系
公共卫生学院
附属第二医院
附属第二医院_神经内科
第二临床医学院、附属第二医院、育英儿童医院
通讯作者Zhang, Xiong; Zhu, Jian-Hong
作者单位
1.Wenzhou Med Univ, Sch Publ Hlth, Dept Prevent Med, Wenzhou, Zhejiang, Peoples R China;
2.Wenzhou Med Univ, Inst Nutr & Dis, Sch Publ Hlth, Wenzhou, Zhejiang, Peoples R China;
3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Wenzhou, Zhejiang, Peoples R China;
4.Wenzhou Med Univ, Affiliated Hosp 2, Inst Geriatr Neurol, Wenzhou, Zhejiang, Peoples R China;
5.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China
第一作者单位公共卫生学院;  预防医学系;  附属第二医院;  第二临床医学院,附属第二医院、育英儿童医院;  神经内科
通讯作者单位附属第二医院;  第二临床医学院,附属第二医院、育英儿童医院;  神经内科;  温州医科大学
第一作者的第一单位公共卫生学院
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Ovlyakulov, Begench,Hu, Bei-Lei,Kan, Hong-Yang,et al. Escitalopram moderately outperforms citalopram towards anti-neuroinflammation and neuroprotection in 6-hydroxydopamine-in-duced mouse model of Parkinson's disease[J]. International Immunopharmacology,2024,139.
APA Ovlyakulov, Begench., Hu, Bei-Lei., Kan, Hong-Yang., Guo, Qing., Li, Xiao-Fen., ... & Zhu, Jian-Hong. (2024). Escitalopram moderately outperforms citalopram towards anti-neuroinflammation and neuroprotection in 6-hydroxydopamine-in-duced mouse model of Parkinson's disease. International Immunopharmacology, 139.
MLA Ovlyakulov, Begench,et al."Escitalopram moderately outperforms citalopram towards anti-neuroinflammation and neuroprotection in 6-hydroxydopamine-in-duced mouse model of Parkinson's disease".International Immunopharmacology 139(2024).

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