Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth

doi:10.1016/j.expneurol.2024.114886

科研成果详情

题名	Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth
作者	Hu, Zhenxin 1,2,3; Tan, Huixin3; Zhang, Yu3; Qi, Tengfei3; Li, Yijun4; Li, Na 3; Zhou, Ziheng 3; Wang, Yining3; Wang, Haoli 3; Zhang, Hongyu3; Wang, Qingqing 1,2,3
发表日期	2024-09
发表期刊	Experimental Neurology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Irisflorentin Spinal cord injury Blood-spinal cord barrier Axonal growth Pericytes Endoplasmic reticulum stress
其他关键词	PERICYTES ; CELLS
摘要	Spinal cord injury (SCI) induces the disruption of the blood-spinal cord barrier (BSCB) and the failure of axonal growth. SCI activates a complex series of responses, including cell apoptosis and endoplasmic reticulum (ER) stress. Pericytes play a critical role in maintaining BSCB integrity and facilitating tissue growth and repair. However, the roles of pericytes in SCI and the potential mechanisms underlying the improvements in functional recovery in SCI remain unclear. Recent evidence indicates that irisflorentin exerts neuroprotective effects against Parkinson's disease; however, whether it has potential protective roles in SCI or not is still unknown. In this study, we found that the administration of irisflorentin significantly inhibited pericyte apoptosis, protected BSCB integrity, promoted axonal growth, and ultimately improved locomotion recovery in a rat model of SCI. In vitro, we found that the positive effects of irisflorentin on axonal growth were likely to be mediated by regulating the crosstalk between pericytes and neurons. Furthermore, irisflorentin effectively ameliorated ER stress caused by incubation with thapsigargin (TG) in pericytes. Meanwhile, the protective effect of irisflorentin on BSCB disruption is strongly related to the reduction of pericyte apoptosis via inhibition of ER stress. Collectively, our findings demonstrate that irisflorentin is beneficial for functional recovery after SCI and that pericytes are a valid target of interest for future SCI therapies.
资助项目	National Natural Science Foun-dation of China [82102313]; Natural Science Foundation of Zhejiang Province [LQ21H060009]
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN	0014-4886
EISSN	1090-2430
卷号	379
DOI	10.1016/j.expneurol.2024.114886
页数	11
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:001274621700001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38996862
SCOPUSEID	2-s2.0-85198587951
通讯作者地址	[Zhang, Hongyu;Wang, Qingqing]Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315302, Peoples R China.
Scopus学科分类	Neurology;Developmental Neuroscience
SCOPUS_ID	SCOPUS_ID:85198587951
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216811
专题	附属第二医院附属第一医院第二临床医学院，附属第二医院、育英儿童医院其他_温州医科大学慈溪生物医药研究院
通讯作者	Zhang, Hongyu; Wang, Qingqing
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthoped, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325088, Peoples R China; 3.Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315302, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325015, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 其他_温州医科大学慈溪生物医药研究院
通讯作者单位	其他_温州医科大学慈溪生物医药研究院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Hu, Zhenxin,Tan, Huixin,Zhang, Yu,et al. Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth[J]. Experimental Neurology,2024,379.
APA	Hu, Zhenxin., Tan, Huixin., Zhang, Yu., Qi, Tengfei., Li, Yijun., ... & Wang, Qingqing. (2024). Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth. Experimental Neurology, 379.
MLA	Hu, Zhenxin,et al."Irisflorentin improves functional recovery after spinal cord injury by protecting the blood-spinal cord barrier and promoting axonal growth".Experimental Neurology 379(2024).