Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy

doi:10.1186/s13098-024-01418-5

科研成果详情

题名	Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy
作者	Yu, Xinyue 1; Jin, Tianyu2,3; Zhu, Luyi4; Guo, Shunyuan 2; Deng, Binbin4; Cheng, Yifan1,2
发表日期	2024-07-25
发表期刊	Diabetology and Metabolic Syndrome 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Diabetic neuropathy Iron status Causality Mendelian randomization
其他关键词	MENDELIAN RANDOMIZATION ; SERUM FERRITIN ; JIANGSU ; ADULTS ; STORES
摘要	Background Diabetic neuropathy (DN), a frequent complication in individuals with diabetes mellitus (DM), is hypothesized to have a correlation with systemic iron status, though the nature of this relationship remains unclear. This study employs two-sample Mendelian randomization (MR) analysis to explore this potential genetic association. Methods We used genetic instruments significant associated with iron status including serum iron, ferritin, transferrin, and transferrin saturation, derived from an extensive Genome-Wide Association Study (GWAS) undertaken by the Genetics of Iron Status Consortium, involving a cohort of 48,972 European ancestry individuals. Summary statistics for DN were collected from a public GWAS, including 1,415 patients and 162,201 controls of European descent. Our MR analysis used the inverse-variance-weighted (IVW) method, supplemented by MR-Egger, weighted-median (WM) methods, Cochran's Q test, MR-Egger intercept analysis, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO) method, and leave-one-out analysis to ensure robustness and consistency of the findings. Results No genetic causal relationship was found between iron status markers and DN (all IVW p value > 0.05). Interestingly, a causative effect of DN on ferritin (IVW: OR = 0.943, 95% CI = 0.892-0.996, p = 0.035) and transferrin saturation (IVW: OR = 0.941, 95% CI = 0.888-0.998, p = 0.044) emerged. Sensitivity analyses confirmed the absence of significant heterogeneity and horizontal pleiotropy. Conclusion While systemic iron status was not found to be causally related to DN, our findings suggest that DN may increase the risk of iron deficiency. These results provide further evidence supporting iron supplementation in patients with DN.
资助项目	State Administration of Traditional Chinese Medicine of the People's Republic of China - Zhejiang Provincial Administration of Traditional Chinese Medicine Joint Science and Technology Program Project
出版者	BMC
ISSN	1758-5996
EISSN	1758-5996
卷号	16 期号:1
DOI	10.1186/s13098-024-01418-5
页数	8
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001277668800002
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39054539
SCOPUSEID	2-s2.0-85199485640
通讯作者地址	[Cheng, Yifan]Wenzhou Med Univ, Alberta Inst, Wenzhou, Peoples R China. ; [Cheng, Yifan]Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Ctr Rehabil Med,Dept Neurol, Hangzhou, Zhejiang, Peoples R China. ; [Deng, Binbin]Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China.
Scopus学科分类	Internal Medicine;Endocrinology, Diabetes and Metabolism
SCOPUS_ID	SCOPUS_ID:85199485640
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216793
专题	阿尔伯塔学院附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院附属第二医院_康复科
通讯作者	Deng, Binbin; Cheng, Yifan
作者单位	1.Wenzhou Med Univ, Alberta Inst, Wenzhou, Peoples R China; 2.Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Ctr Rehabil Med,Dept Neurol, Hangzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Yuying Childrens Hosp, Wenzhou, Peoples R China; 4.Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China
第一作者单位	阿尔伯塔学院
通讯作者单位	阿尔伯塔学院; 附属第一医院
第一作者的第一单位	阿尔伯塔学院
推荐引用方式 GB/T 7714	Yu, Xinyue,Jin, Tianyu,Zhu, Luyi,et al. Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy[J]. Diabetology and Metabolic Syndrome,2024,16(1).
APA	Yu, Xinyue, Jin, Tianyu, Zhu, Luyi, Guo, Shunyuan, Deng, Binbin, & Cheng, Yifan. (2024). Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy. Diabetology and Metabolic Syndrome, 16(1).
MLA	Yu, Xinyue,et al."Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy".Diabetology and Metabolic Syndrome 16.1(2024).