The association between ferritin levels and all-cause mortality in stroke patients

doi:10.3389/fneur.2024.1386408

科研成果详情

题名	The association between ferritin levels and all-cause mortality in stroke patients
作者	Xia, Xuefen1; Liu, Jiongjiong 2; Fang, Wenqiang1; Chen, Zhibo1; Wang, Jie 3; Xu, Huiqin1
发表日期	2024-06-26
发表期刊	FRONTIERS IN NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ferritin all-cause mortality stroke mimic mortality risk
其他关键词	SERUM FERRITIN ; EPIDEMIOLOGY
摘要	Purpose: The purpose of study was to describe the association between ferritin and all-cause mortality of cases with stroke. Methods: Clinical data derived from Multiparameter Intelligent Monitoring in Intensive Care were analyzed. The primary endpoint was 30-day mortality. The potential prognostic roles of Ferritin L were analyzed by Cox proportional hazard models. The independent prognostic roles of Ferritin L in the cases were analyzed by smooth curve fitting. Results: Concerning 30-day mortality, the HR (95% CI) for a high Ferritin (>= 373) was 1.925 (1.298, 2.854; p = 0.00113), compared to a low ferritin (< 373). After adjusting for multiple confounders, the HR (95% CI) for a high Ferritin (>= 373) was 1.782 (1.126, 2.820; p = 0.01367), compared to a low Ferritin (< 373). A non-linear association between Ferritin and 30-day mortality was found. Using recursive algorithm and two-piecewise linear regression model, inflection point (IP) was calculated, which was 2,204. On the left side of the IP, there was a positive relationship between Ferritin and 30-day mortality, and the effect size, 95% CI and p value were 1.0006 (1.0004, 1.0009) p < 0.0001, respectively. On the right of the IP, the effect size, 95% CI and p value were 1.0000 (1.0000, 1.0000) and 0.3107, respectively. Conclusion: Ferritin was associated with increased risk of stroke; it is important to further examine the association if the increased uric acid would increase the outcome of stroke in a longitudinal study. The non-linear relationship between Ferritin and all-cause mortality of stroke was observed. Ferritin was a risk factor for the outcome of stroke when ferritin was <2204.
出版者	FRONTIERS MEDIA SA
ISSN	1664-2295
卷号	15
DOI	10.3389/fneur.2024.1386408
页数	7
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:001268919800001
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	38988599
SCOPUSEID	2-s2.0-85198032211
通讯作者地址	[Xu, Huiqin]Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China. ; [Wang, Jie]Second Affiliated Hosp Wenzhou Med Univ, Wenzhou, Peoples R China.
Scopus学科分类	Neurology;Neurology (clinical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216779
专题	附属第一医院附属第二医院_妇产科
通讯作者	Wang, Jie; Xu, Huiqin
作者单位	1.Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China; 2.Anhui Med Univ, Dept Gen Practice, Fuyang Hosp Affiliated, Hefei, Anhui, Peoples R China; 3.Second Affiliated Hosp Wenzhou Med Univ, Wenzhou, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院; 妇产科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xia, Xuefen,Liu, Jiongjiong,Fang, Wenqiang,et al. The association between ferritin levels and all-cause mortality in stroke patients[J]. FRONTIERS IN NEUROLOGY,2024,15.
APA	Xia, Xuefen, Liu, Jiongjiong, Fang, Wenqiang, Chen, Zhibo, Wang, Jie, & Xu, Huiqin. (2024). The association between ferritin levels and all-cause mortality in stroke patients. FRONTIERS IN NEUROLOGY, 15.
MLA	Xia, Xuefen,et al."The association between ferritin levels and all-cause mortality in stroke patients".FRONTIERS IN NEUROLOGY 15(2024).