CD147 protein molecule expression and chromosomal instability in the pathogenesis and prognosis of thyroid cancer

doi:10.1016/j.ijbiomac.2024.133944

科研成果详情

题名	CD147 protein molecule expression and chromosomal instability in the pathogenesis and prognosis of thyroid cancer
作者	Zhou, Yuying 1; Fang, Jiayu2; Chi, Yili 1; Wu, Linfeng 1; Chen, Weike 1; Xiao, Rongyao 1; Xue, Rong 1; Qian, Ziliang 3,4; Dai, Chan 3; Shen, Shurong 5
发表日期	2024-09
发表期刊	International Journal of Biological Macromolecules 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Thyroid cancer Chromosomal instability Tumor size High risk Disease-free survival
其他关键词	TUMOR-SUPPRESSOR GENE ; DETERMINANTS ; ASSOCIATION ; MORTALITY ; SURVIVAL ; TRENDS
摘要	Low-coverage whole genome sequencing was performed for tissue samples from thyroid patients who received surgery treatment from 2015 to 2021. The potential biological significance of CD147 protein in thyroid cancer was explored through correlation analysis of CD147 protein expression level and clinical features of thyroid cancer patients. Low coverage whole genome sequencing was performed on the extracted DNA samples. The copy number analysis software was used to analyze the sequencing data, calculate the copy number of CD147 gene, further verify the expression of CD147 gene, and analyze its association with clinical features. The relationship between CIN and high risk was evaluated in the internal cohort. The association of CIN with the diseasefree survival was validated in the cohort from The Cancer Genome Atlas Program. Thyroglobulin plays a key role in regulating thyroid function and maintaining normal metabolic rate. By sequencing tissue samples from this study, we can gain a deeper understanding of the association between cin and thyroid disease. The percentage of high risk patients in the multiple CIN group (77.8 %) was significantly higher than that in the 22q negative group (31.3 %), BRAF V600E group (22.2 %) and all negative group (25.0 %; p = 0.043).
资助项目	Major Scientific and Technological Innovation Tackling Medical and Health Projects [ZY2021008]
出版者	ELSEVIER
ISSN	0141-8130
EISSN	1879-0003
卷号	276 期号:Pt 2
DOI	10.1016/j.ijbiomac.2024.133944
页数	10
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001275664400001
收录类别	SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号	20243016738010
EI主题词	Proteins
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	39029817
SCOPUSEID	2-s2.0-85198912875
通讯作者地址	[Shen, Shurong]Wenzhou Cent Hosp, Breast Surg, Wenzhou 325000, Peoples R China.
Scopus学科分类	Structural Biology;Biochemistry;Molecular Biology
SCOPUS_ID	SCOPUS_ID:85198912875
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216771
专题	第二临床医学院，附属第二医院、育英儿童医院_中医系
通讯作者	Shen, Shurong
作者单位	1.Wenzhou Hosp Integrated Tradit Chinese & Western M, Oncol & Hematol, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Sch Tradit Chinese Med, Wenzhou 325000, Peoples R China; 3.Suzhou Hongyuan Biotech Inc, Suzhou 215125, Peoples R China; 4.Prophet Genom Inc, San Jose, CA USA; 5.Wenzhou Cent Hosp, Breast Surg, Wenzhou 325000, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yuying,Fang, Jiayu,Chi, Yili,et al. CD147 protein molecule expression and chromosomal instability in the pathogenesis and prognosis of thyroid cancer[J]. International Journal of Biological Macromolecules,2024,276(Pt 2).
APA	Zhou, Yuying., Fang, Jiayu., Chi, Yili., Wu, Linfeng., Chen, Weike., ... & Shen, Shurong. (2024). CD147 protein molecule expression and chromosomal instability in the pathogenesis and prognosis of thyroid cancer. International Journal of Biological Macromolecules, 276(Pt 2).
MLA	Zhou, Yuying,et al."CD147 protein molecule expression and chromosomal instability in the pathogenesis and prognosis of thyroid cancer".International Journal of Biological Macromolecules 276.Pt 2(2024).