Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study

doi:10.2147/NDT.S458106

科研成果详情

题名	Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study
作者	Mou, Shaoqi1; Yan, Shiyu1; Shen, Shanhong 2; Shuai, Yibin 2; Li, Gang 3; Shen, Zhongxia 2; Shen, Ping 2
发表日期	2024
发表期刊	NEUROPSYCHIATRIC DISEASE AND TREATMENT 影响因子和分区
语种	英语
原始文献类型	Article
关键词	electroencephalogram EEG disease course anxiety disorder brain function machine learning
其他关键词	GENERALIZED ANXIETY ; UNTREATED ILLNESS ; PRIMARY-CARE ; LIFE-SPAN ; DSM-IV ; CONNECTIVITY ; MACHINE ; PREVALENCE ; CLASSIFICATION ; DEPRESSION
摘要	Objective: Anxiety disorder (AD) is a common disabling disease. The prolonged disease course may lead to impaired cognitive performance, brain function, and a bad prognosis. Few studies have examined the effect of disease course on brain function by Methods: Resting-state EEG analysis was performed in 34 AD patients. The 34 patients with AD were divided into two groups according to the duration of their illness: anxious state (AS) and generalized anxiety disorder (GAD). Then, EEG features, including univariate power spectral density (PSD), fuzzy entropy (FE), and multivariable functional connectivity (FC), were extracted and compared between AS and GAD. These features were evaluated by three previously validated machine learning methods to test the accuracy of classification in AS and GAD. Results: Significant decreased PSD and FE in GAD were detected compared with AS, especially in the Alpha 2 band. In addition, FC analysis indicated that GAD patients' connection between the left and right hemispheres decreased. Based on machine learning, AS and GAD are classified on a six-month criterion with the highest classification accuracy of up to 0.99 +/- 0.0015. Conclusion: The brain function of patients is more severely impaired in AD patients with longer illness duration. Resting-state EEG demonstrated to be a promising examination in the classification in GAD and AS using machine learning methods with better classification accuracy.
资助项目	Huzhou Public Welfare Research Project Social Development (Key Medical and Health) Category [2023GZB07]
出版者	DOVE MEDICAL PRESS LTD
ISSN	1176-6328
EISSN	1178-2021
卷号	20 页码:1409-1419
DOI	10.2147/NDT.S458106
页数	11
WOS类目	Clinical Neurology ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:001271753900001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39049937
通讯作者地址	[Shen, Zhongxia;Shen, Ping]Huzhou Univ, Huzhou Municipal Hosp 3, Affiliated Hosp, Dept Sleep Med Ctr, Huzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216769
专题	精神医学学院_精神医学系
通讯作者	Shen, Zhongxia; Shen, Ping
作者单位	1.Wenzhou Med Univ, Dept Psychiat, Wenzhou, Peoples R China; 2.Huzhou Univ, Huzhou Municipal Hosp 3, Affiliated Hosp, Dept Sleep Med Ctr, Huzhou, Peoples R China; 3.Zhejiang Normal Univ, Coll Engn, Jinhua, Peoples R China
第一作者单位	精神医学学院_精神医学系
第一作者的第一单位	精神医学学院_精神医学系
推荐引用方式 GB/T 7714	Mou, Shaoqi,Yan, Shiyu,Shen, Shanhong,et al. Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2024,20:1409-1419.
APA	Mou, Shaoqi., Yan, Shiyu., Shen, Shanhong., Shuai, Yibin., Li, Gang., ... & Shen, Ping. (2024). Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study. NEUROPSYCHIATRIC DISEASE AND TREATMENT, 20, 1409-1419.
MLA	Mou, Shaoqi,et al."Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study".NEUROPSYCHIATRIC DISEASE AND TREATMENT 20(2024):1409-1419.