The efficacy and safety of inhaled antibiotics for pneumonia: A systematic review and meta-analysis

doi:10.1016/j.pupt.2024.102315

科研成果详情

题名	The efficacy and safety of inhaled antibiotics for pneumonia: A systematic review and meta-analysis
作者	Zhang, Zengzeng 1; Li, Hong 1; Hu, Yutao1; Sun, Binhui 1; Ke, Tingting 1; Wu, Qihuan 1; Lian, Xiang 1; Yu, Wei 2
发表日期	2024-09
发表期刊	Pulmonary Pharmacology and Therapeutics 影响因子和分区
语种	英语
原始文献类型	Review
关键词	inhaled antibiotics Aminoglycosides Polymyxins Ventilator -associated pneumonia Clinical cure
其他关键词	VENTILATOR-ASSOCIATED PNEUMONIA ; PLUS INTRAVENOUS COLISTIN ; GRAM-NEGATIVE PNEUMONIA ; AEROSOLIZED COLISTIN ; ADJUNCTIVE THERAPY ; NEBULIZED COLISTIN ; CRITICALLY-ILL ; NOSOCOMIAL PNEUMONIA ; POLYMYXIN-B ; AMIKACIN
摘要	Objectives: The aim of this study was to evaluate the efficacy and safety of inhaled antibiotics for adults with pneumonia by meta-analysis. Methods: Literature retrieval was completed through five databases (PubMed, Embase, Cochrane Library, Web of Science and Scopus) by the deadline of May 31, 2024. The process of study selection and data extraction were performed independently by two reviewers. The quality of observational studies and randomized controlled trial (RCT) studies were evaluated by Newcastle Ottawa scale and Jadad scale, respectively. The primary outcomes included mortality, clinical cure, and microbiological cure. Secondary outcomes were recurrence and renal impairment. Results: There were 30 studies were analyzed, including 12 RCT studies and 18 observational studies. Inhaled antibiotics did not significantly reduce mortality in RCT studies (odds ratio (OR) = 1.06, 95 % confidence interval (CI): 0.80-1.41). Inhaled antibiotics were associated with higher rates of clinical cure (OR = 1.47 95%CI: 0.82-2.66 in RCT studies and OR = 2.09, 95%CI: 1.36-3.21 in observational studies) and microbiological cure (OR = 7.00 in RCT studies and OR = 2.20 in observational studies). Subgroup analysis showed patients received inhaled antibiotics combined with intravenous administration and inhaled amikacin had better improvements of mortality, clinical cure and microbiological cure. Inhaled antibiotics were not associated with recurrence. The pooled OR of renal impairment were 0.65 (95%CI: 0.27-1.13;I-squared = 43.5 %, P = 0.124) and 0.63(95%CI: 0.26-1.11;I-squared = 69.0 %, P = 0.110) in RCT studies and observational studies, respectively. Conclusions: Inhaled antibiotics decreased risk of renal impairment and achieved significant improvements of clinical and microbiological cure in patients with pneumoniae.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LTGY24H190002]; Department of Health of Zhejiang province [2024XY041]
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
ISSN	1094-5539
EISSN	1522-9629
卷号	86
DOI	10.1016/j.pupt.2024.102315
页数	8
WOS类目	Pharmacology & Pharmacy ; Respiratory System
WOS研究方向	Pharmacology & Pharmacy ; Respiratory System
WOS记录号	WOS:001273814300001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	3900924
SCOPUSEID	2-s2.0-85198699192
通讯作者地址	[Lian, Xiang]Wenzhou Med Univ, Ningbo Hosp 4, Xiangshan Peoples Hosp Med & Hlth Grp 1, Dept Infect Dis,Affiliated Xiangshan Hosp, Ningbo, Peoples R China. ; [Yu, Wei]Zhejiang Univ, Affiliated Hosp 1,Sch Med, Natl Clin Res Ctr Infect Dis,State Key Lab Diag &, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Hangzhou, Peoples R China.
Scopus学科分类	Pulmonary and Respiratory Medicine;Biochemistry (medical);Pharmacology (medical)
SCOPUS_ID	SCOPUS_ID:85198699192
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216767
专题	其他_附属象山医院（象山县第一人民医院）
通讯作者	Lian, Xiang; Yu, Wei
作者单位	1.Wenzhou Med Univ, Ningbo Hosp 4, Xiangshan Peoples Hosp Med & Hlth Grp 1, Dept Infect Dis,Affiliated Xiangshan Hosp, Ningbo, Peoples R China; 2.Zhejiang Univ, Affiliated Hosp 1,Sch Med, Natl Clin Res Ctr Infect Dis,State Key Lab Diag &, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Hangzhou, Peoples R China
第一作者单位	其他_附属象山医院（象山县第一人民医院）
通讯作者单位	其他_附属象山医院（象山县第一人民医院）
第一作者的第一单位	其他_附属象山医院（象山县第一人民医院）
推荐引用方式 GB/T 7714	Zhang, Zengzeng,Li, Hong,Hu, Yutao,et al. The efficacy and safety of inhaled antibiotics for pneumonia: A systematic review and meta-analysis[J]. Pulmonary Pharmacology and Therapeutics,2024,86.
APA	Zhang, Zengzeng., Li, Hong., Hu, Yutao., Sun, Binhui., Ke, Tingting., ... & Yu, Wei. (2024). The efficacy and safety of inhaled antibiotics for pneumonia: A systematic review and meta-analysis. Pulmonary Pharmacology and Therapeutics, 86.
MLA	Zhang, Zengzeng,et al."The efficacy and safety of inhaled antibiotics for pneumonia: A systematic review and meta-analysis".Pulmonary Pharmacology and Therapeutics 86(2024).