Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children

doi:10.1002/cnr2.2136

科研成果详情

题名	Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children
作者	Lin, Qianru1,2; Chen, Wei 3; Tan, Jiating1,2; Qian, Sifan1,2; Su, Huarong1,2; Zhao, Liang1,2; Yuan, Li 4; Ruan, Jichen1,2,5; Huang, Xiaokai 1,2,5; Zhou, Haixia1,2,5
发表日期	2024-07
发表期刊	CANCER REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	glioma polymorphism RAN RANBP2 susceptibility
其他关键词	M(6)A MODIFICATION ; PROGRESSION ; PROMOTE ; RISK
摘要	Background: Glioma is the most prevalent pediatric central nervous system malignancy. RAN, member RAS oncogene family (RAN), is a key signaling molecule that regulates the polymerization of microtubules during mitosis. RAN binding protein 2 (RANBP2) is involved in DNA replication, mitosis, metabolism, and tumorigenesis. The effects of RAN and RANBP2 gene polymorphisms on glioma susceptibility in Chinese children are currently unknown. Aims: This study aimed to evaluate the association between RAN and RANBP2 gene polymorphisms and glioma susceptibility in Chinese children. Methods and Results: We recruited 191 patients with glioma and 248 children without cancer for this case-control study. Polymerase chain reaction-based TaqMan was applied to gene sequencing and typing. Logistic regression model-calculated odds ratio and 95% confidence interval were used to verify whether the gene polymorphisms (RAN rs56109543 C>T, rs7132224 A>G, rs14035 C>T, and RANBP2 rs2462788 C>T) influence glioma susceptibility. Based on age, gender, tumor subtype, and clinical stage, stratified analyses of risk and protective genotypes were conducted. p values for mutant genotype analyses were all >0.05, indicating no significant correlation between these gene polymorphisms and glioma risk. Conclusion: RAN and RANBP2 gene polymorphisms were not found to be statistically significantly associated with glioma susceptibility in Chinese children. Other potential functional gene polymorphism loci of RAN and RANBP2 will need to be evaluated in the search for novel glioma biomarkers.
资助项目	Wenzhou Science and Technology Project
出版者	WILEY
ISSN	2573-8348
EISSN	2573-8348
卷号	7 期号:7
DOI	10.1002/cnr2.2136
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001274548200001
收录类别	ESCI ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39041645
SCOPUSEID	2-s2.0-85199185613
通讯作者地址	[Huang, Xiaokai;Zhou, Haixia]Wenzhou Med Univ, Affiliated Hosp 2, Dept Hematol, Wenzhou, Zhejiang, Peoples R China. ; [Huang, Xiaokai;Zhou, Haixia]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China. ; [Huang, Xiaokai;Zhou, Haixia]Wenzhou Med Univ, Affiliated Hosp 2, Key Lab Pediat Hematol & Oncol Dis Wenzhou, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216765
专题	附属第二医院_血液内科附属第二医院第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Huang, Xiaokai; Zhou, Haixia
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Hematol, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China; 3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Pediat Surg, Guangzhou, Guangdong, Peoples R China; 4.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Pathol, Guangzhou, Guangdong, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 2, Key Lab Pediat Hematol & Oncol Dis Wenzhou, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第二医院_血液内科; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	附属第二医院_血液内科; 第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	附属第二医院_血液内科
推荐引用方式 GB/T 7714	Lin, Qianru,Chen, Wei,Tan, Jiating,et al. Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children[J]. CANCER REPORTS,2024,7(7).
APA	Lin, Qianru., Chen, Wei., Tan, Jiating., Qian, Sifan., Su, Huarong., ... & Zhou, Haixia. (2024). Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children. CANCER REPORTS, 7(7).
MLA	Lin, Qianru,et al."Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children".CANCER REPORTS 7.7(2024).