The effect of remimazolam-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia on emergence delirium in children undergoing tonsillectomy and adenoidectomy: study protocol for a prospective randomized controlled trial

doi:10.3389/fphar.2024.1373006

科研成果详情

题名	The effect of remimazolam-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia on emergence delirium in children undergoing tonsillectomy and adenoidectomy: study protocol for a prospective randomized controlled trial
作者	Ma, Hong-Yu 1,2,3,4; Cai, Yu-Hang1,2,3,4; Zhong, John Wei 5; Chen, Jia1,2,3,4; Wang, Zhen 6; Lin, Chao-Yi1,2,3,4; Wang, Qiao-Qiao1,2,3,4; Liu, Hua-Cheng1,2,3,4
发表日期	2024-06-25
发表期刊	FRONTIERS IN PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	remimazolam emergence delirium sevoflurane children general anesthesia
其他关键词	PROPOFOL ; PHARMACOKINETICS ; REMIFENTANIL ; AGITATION ; EFFICACY ; SAFETY ; SCALE ; PAIN
摘要	Background: Remimazolam, a new ultrashort-acting benzodiazepine, is becoming increasingly applied in general anesthesia. This study is designed to investigate the effect of remimazolam-based total intravenous anesthesia and sevoflurane-based inhalation anesthesia on emergence delirium in pediatric tonsillectomy and adenoidectomy. Methods and analysis: This is a monocentric, prospective, randomized, double-blind clinical trial. A total of 90 pediatric patients will be randomized to receive remimazolam-based total intravenous anesthesia (remimazolam group, n = 45) or sevoflurane-based inhalation anesthesia (sevoflurane group, n = 45). The primary outcome will be the incidence of emergence delirium, which will be evaluated using the Pediatric Anesthesia Emergence Delirium (PAED) scale. The secondary outcomes include the extubation time, recovery time, behavior change using the post-hospitalization behavior questionnaire for ambulatory surgery (PHBQ-AS), and adverse events. Ethics and dissemination: This study has been approved by the Institutional Review Board (IRB) of the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University (2023-K-262-02). Clinical trial registration: ClinicalTrials.gov, identifier NCT06214117.
资助项目	Major Science Technology Projects of Wenzhou, Zhejiang, China [ZY2023030]; Wenzhou Science and Technology Bureau [Y20220948]
出版者	FRONTIERS MEDIA SA
ISSN	1663-9812
EISSN	1663-9812
卷号	15
DOI	10.3389/fphar.2024.1373006
页数	9
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001265251800001
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	38983921
SCOPUSEID	2-s2.0-85197793984
通讯作者地址	[Liu, Hua-Cheng]Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol & Perioperat Med, Wenzhou 325027, Zhejiang, Peoples R China. ; [Liu, Hua-Cheng]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China. ; [Liu, Hua-Cheng]Wenzhou Med Univ, Key Lab Pediat Anesthesiol, Minist Educ, Wenzhou, Zhejiang, Peoples R China. ; [Liu, Hua-Cheng]Wenzhou Med Univ, Key Lab Anesthesiol Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216725
专题	附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第二医院_麻醉重点学科实验室
通讯作者	Liu, Hua-Cheng
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol & Perioperat Med, Wenzhou 325027, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Key Lab Pediat Anesthesiol, Minist Educ, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Key Lab Anesthesiol Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China; 5.Univ Texas Southwestern Med Ctr, Dept Anesthesiol & Pain Management, Dallas, TX USA; 6.Hangzhou Med Coll, Affiliated Peoples Hosp, Zhejiang Prov Peoples Hosp, Ctr Lab Med,Allergy Ctr,Dept Transfus Med, Hangzhou, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 麻醉科; 温州医科大学; 麻醉重点学科实验室
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 麻醉科; 温州医科大学; 麻醉重点学科实验室
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Ma, Hong-Yu,Cai, Yu-Hang,Zhong, John Wei,et al. The effect of remimazolam-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia on emergence delirium in children undergoing tonsillectomy and adenoidectomy: study protocol for a prospective randomized controlled trial[J]. FRONTIERS IN PHARMACOLOGY,2024,15.
APA	Ma, Hong-Yu., Cai, Yu-Hang., Zhong, John Wei., Chen, Jia., Wang, Zhen., ... & Liu, Hua-Cheng. (2024). The effect of remimazolam-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia on emergence delirium in children undergoing tonsillectomy and adenoidectomy: study protocol for a prospective randomized controlled trial. FRONTIERS IN PHARMACOLOGY, 15.
MLA	Ma, Hong-Yu,et al."The effect of remimazolam-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia on emergence delirium in children undergoing tonsillectomy and adenoidectomy: study protocol for a prospective randomized controlled trial".FRONTIERS IN PHARMACOLOGY 15(2024).