Research Progress on Mechanisms of Modulating Gut Microbiota to Improve Symptoms of Major Depressive Disorder

doi:10.24976/Discov.Med.202436186.125

科研成果详情

题名	Research Progress on Mechanisms of Modulating Gut Microbiota to Improve Symptoms of Major Depressive Disorder
作者	Lin, Jixin 1; Chen, Yan 1; Li, Ting 2; Zhu, Cheng 3; Qiu, Yaju 4; Yu, Enyan 4
发表日期	2024-07
发表期刊	DISCOVERY MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	microbiota major depressive disorder
其他关键词	METAANALYSIS ; PROBIOTICS ; BEHAVIOR ; TRANSPLANTATION ; INFLAMMATION ; ACUPUNCTURE ; PATHWAY ; IMMUNE ; ACIDS ; RATS
摘要	Major depressive disorder (MDD) is a clinical condition that significantly impacts patients' physical and mental well-being, quality of life, and social functioning. The pathogenesis of MDD remains unclear, but accumulating evidence suggests a close relationship between gut microbiota and the occurrence and progression of MDD. Gut microbiota refers to the microbial community in the human intestine, which engages in bidirectional communication with the host via the gut-brain axis and plays a pivotal role in influencing the host's metabolism, immune system, endocrine system, and nervous system. Modulating gut microbiota entails restoring the balance and function of the intestinal flora through methods such as probiotic intake, fecal transplantation, and dietary intervention. Such modulation has been shown to effectively alleviate depressive symptoms in the host. This review synthesizes recent advancements in research on gut microbiota modulation for ameliorating depressive symptoms and can serve as a foundation for further exploration of the gut microbiota's role in MDD and its potential therapeutic benefits.
资助项目	Science and Tech-nology Plan Project of Zhejiang Province [2021C03106]
出版者	DISCOVERY MEDICINE
ISSN	1539-6509
EISSN	1944-7930
卷号	36 期号:186 页码:1354-1362
DOI	10.24976/Discov.Med.202436186.125
页数	9
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:001273743700004
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39054706
通讯作者地址	[Yu, Enyan]Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Psychol Med, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216706
专题	第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Yu, Enyan
作者单位	1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Zhejiang, Peoples R China; 2.Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Dept Rehabil Med, Affiliated Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Coll Psychiat, Wenzhou 325035, Zhejiang, Peoples R China; 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Psychol Med, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Lin, Jixin,Chen, Yan,Li, Ting,et al. Research Progress on Mechanisms of Modulating Gut Microbiota to Improve Symptoms of Major Depressive Disorder[J]. DISCOVERY MEDICINE,2024,36(186):1354-1362.
APA	Lin, Jixin, Chen, Yan, Li, Ting, Zhu, Cheng, Qiu, Yaju, & Yu, Enyan. (2024). Research Progress on Mechanisms of Modulating Gut Microbiota to Improve Symptoms of Major Depressive Disorder. DISCOVERY MEDICINE, 36(186), 1354-1362.
MLA	Lin, Jixin,et al."Research Progress on Mechanisms of Modulating Gut Microbiota to Improve Symptoms of Major Depressive Disorder".DISCOVERY MEDICINE 36.186(2024):1354-1362.