Amyloid-β but not tau accumulation is strongly associated with longitudinal cognitive decline

doi:10.1111/cns.14860

科研成果详情

题名	Amyloid-β but not tau accumulation is strongly associated with longitudinal cognitive decline
作者	Wang, Wenwen1; Huang, Jiani 2; Qian, Shuangjie2; Zheng, Yi 2; Yu, Xinyue 3; Jiang, Tao2; Ai, Ruixue 4; Hou, Jialong2; Ma, Enzi 5; Cai, Jinlai 2; He, Haijun2; Wang, XinShi2; Xie, Chenglong 2,6,7,8
发表日期	2024-07
发表期刊	CNS NEUROSCIENCE & THERAPEUTICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Alzheimer's disease amyloid-beta cognition function tau accumulation
其他关键词	ALZHEIMERS-DISEASE ; DEPOSITION ; PATHOLOGY
摘要	Objective: Alzheimer's disease (AD) pathology is featured by the extracellular accumulation of amyloid-beta (A beta) plaques and intracellular tau neurofibrillary tangles in the brain. We studied whether A beta and tau accumulation are independently associated with future cognitive decline in the AD continuum. Methods: Data were acquired from the Alzheimer's Disease Neuroimaging Initiative (ADNI) public database. A total of 1272 participants were selected based on the availability of A beta-PET and CSF tau at baseline and of those 777 participants with follow-up visits. Results: We found that A beta-PET and CSF tau pathology were related to cognitive decline across the AD clinical spectrum, both as potential predictors for dementia progression. Among them, A beta-PET (A + T- subjects) is an independent reliable predictor of longitudinal cognitive decline in terms of ADAS-13, ADNI-MEM, and MMSE scores rather than tau pathology (A - T+ subjects), indicating tau accumulation is not closely correlated with future cognitive impairment without being driven by A beta deposition. Of note, a high percentage of APOE epsilon 4 carriers with A beta pathology (A+) develop poor memory and learning capacity. Interestingly, this condition is not recurrence in terms of the ADNI-MEM domain when adding APOE epsilon 4 status. Finally, the levels of A beta-PET SUVR related to glucose hypometabolism more strongly in subjects with A + T- than A - T+ both happen at baseline and longitudinal changes. Conclusions: In conclusion, A beta-PET alone without tau pathology (A + T-) measure is an independent reliable predictor of longitudinal cognitive decline but may nonetheless forecast different status of dementia progression. However, tau accumulation alone without A beta pathology background (A - T+) was not enough to be an independent predictor of cognitive worsening.
资助项目	Natural Science Foundation of Zhejiang Province [LQ23H090007, LZ23H090001, Y19H090059]; National Natural Science Foundation of China [81600977, 82001363, 82271469]; Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2023R01002]
出版者	WILEY
ISSN	1755-5930
EISSN	1755-5949
卷号	30 期号:7
DOI	10.1111/cns.14860
页数	15
WOS类目	Neurosciences ; Pharmacology & Pharmacy
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS记录号	WOS:001268407200001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39014268
SCOPUSEID	2-s2.0-85198616316
通讯作者地址	[Wang, XinShi;Xie, Chenglong]Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Peoples R China.
Scopus学科分类	Pharmacology;Psychiatry and Mental Health;Physiology (medical);Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216696
专题	附属第二医院附属第一医院阿尔伯塔学院卓越中心_老年研究院
通讯作者	Wang, XinShi; Xie, Chenglong
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Yuying Childrens Hosp, Ctr Tradit Chinese Med, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Univ, Alberta Inst, Wenzhou, Zhejiang, Peoples R China; 4.Univ Oslo, Akershus Univ Hosp, Dept Clin Mol Biol, Lorenskog, Norway; 5.Tradit Chinese & Western Med Hosp Wenzhou, Dept Neurol, Wenzhou, Zhejiang, Peoples R China; 6.Oujiang Lab, Wenzhou, Zhejiang, Peoples R China; 7.Wenzhou Med Univ, Inst Aging, Key Lab Alzheimers Dis Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China; 8.Wenzhou Med Univ, Affiliated Hosp 1, Geriatr Med Ctr, Dept Geriatr, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Wang, Wenwen,Huang, Jiani,Qian, Shuangjie,et al. Amyloid-β but not tau accumulation is strongly associated with longitudinal cognitive decline[J]. CNS NEUROSCIENCE & THERAPEUTICS,2024,30(7).
APA	Wang, Wenwen., Huang, Jiani., Qian, Shuangjie., Zheng, Yi., Yu, Xinyue., ... & Xie, Chenglong. (2024). Amyloid-β but not tau accumulation is strongly associated with longitudinal cognitive decline. CNS NEUROSCIENCE & THERAPEUTICS, 30(7).
MLA	Wang, Wenwen,et al."Amyloid-β but not tau accumulation is strongly associated with longitudinal cognitive decline".CNS NEUROSCIENCE & THERAPEUTICS 30.7(2024).