Rare-Earth Metal-Based Nanosystems for Facilitating Neural Stem Cell Differentiation into Neurons and Enhancing Axonal Stability

doi:10.1021/acsanm.4c02057

科研成果详情

题名	Rare-Earth Metal-Based Nanosystems for Facilitating Neural Stem Cell Differentiation into Neurons and Enhancing Axonal Stability
作者	Zhang, Yuan 1,2,3; Zheng, Zhibo 2,4; Gao, Jun 1; Bao, Xinjie 1; Zhang, Wenjing5; Liu, Lei 6,7,8; Sun, Yulong 9; Li, Yongning 1,2
发表日期	2024-07-11
发表期刊	ACS APPLIED NANO MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	axonal growth neuronaldifferentiation neuralstem cells nerve injury repair rare-earth metal upconversion nanoparticles
其他关键词	UP-CONVERSION NANOPARTICLES
摘要	Overcoming neural injury and facilitating effective repair pose considerable challenges in the field of neural rehabilitation, characterized by extensive disability and limited recovery rates. A critical aspect of reconstructing a functional nervous system revolves around the successful development of operational axons. In our investigation of rare-earth metal-based upconversion nanoparticles (UCNPs), we have discovered their ability to induce the differentiation of PC-12 cells into neurons. Expanding our inquiry into the implications of UCNPs in neural rehabilitation, we have also applied them in primary mouse neurogenesis, resulting in a significant increase in both neural length and quantity. Furthermore, when used during the induction of primary neural stem cells (NSCs), UCNP treatment has shown a dual effect: it enhances the expression of the neuronal marker TUBB3 while simultaneously inhibiting differentiation into astrocytes. This multifaceted impact was sustained in a prolonged neural sphere differentiation experiment, where UCNPs notably enhance the stability of neuronal axons and facilitate the establishment of intercellular connections. In summary, at the cellular level, introducing UCNPs not only promotes neuronal differentiation in NSCs but also sustains axonal growth, stability, and the formation of intercellular connections. These collective findings highlight the significant potential of UCNPs in advancing the frontiers of neural rehabilitation.
资助项目	Project of the National Natural Science Foundation of China [82201247, 32293212, 92254301]; Ministry of Science and Technology of China [2020YFA0803702]; Project for Young Scientists in Basic Research of the Chinese Academy of Sciences [YSBR-075]
出版者	AMER CHEMICAL SOC
ISSN	2574-0970
EISSN	2574-0970
卷号	7 期号:14 页码:16154-16161
DOI	10.1021/acsanm.4c02057
页数	8
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001266678700001
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20242916715541
EI主题词	Stem cells
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 547.2 Rare Earth Metals ; 761 Nanotechnology ; 804.2 Inorganic Compounds ; 913.5 Maintenance
URL	查看原文
SCOPUSEID	2-s2.0-85198552807
通讯作者地址	[Li, Yongning]Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China. ; [Li, Yongning]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Int Med Serv, Beijing 100730, Peoples R China. ; [Liu, Lei]Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, State Key Lab Membrane Biol, Beijing 100101, Peoples R China. ; [Liu, Lei]Univ Chinese Acad Sci, Beijing 100049, Peoples R China. ; [Liu, Lei]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China. ; [Sun, Yulong]Macquarie Univ, Fac Sci & Engn, Sch Nat Sci, Macquarie Pk, NSW 2109, Australia.
Scopus学科分类	Materials Science (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216685
专题	眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_医学工程系
通讯作者	Liu, Lei; Sun, Yulong; Li, Yongning
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China; 2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Int Med Serv, Beijing 100730, Peoples R China; 3.Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China; 4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Thorac Surg, Dept Int Med Serv, Beijing 100730, Peoples R China; 5.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Sch Biomed Engn, Wenzhou 325027, Peoples R China; 6.Chinese Acad Sci, Inst Zool, Key Lab Organ Regenerat & Reconstruct, State Key Lab Membrane Biol, Beijing 100101, Peoples R China; 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 8.Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China; 9.Macquarie Univ, Fac Sci & Engn, Sch Nat Sci, Macquarie Pk, NSW 2109, Australia
推荐引用方式 GB/T 7714	Zhang, Yuan,Zheng, Zhibo,Gao, Jun,et al. Rare-Earth Metal-Based Nanosystems for Facilitating Neural Stem Cell Differentiation into Neurons and Enhancing Axonal Stability[J]. ACS APPLIED NANO MATERIALS,2024,7(14):16154-16161.
APA	Zhang, Yuan., Zheng, Zhibo., Gao, Jun., Bao, Xinjie., Zhang, Wenjing., ... & Li, Yongning. (2024). Rare-Earth Metal-Based Nanosystems for Facilitating Neural Stem Cell Differentiation into Neurons and Enhancing Axonal Stability. ACS APPLIED NANO MATERIALS, 7(14), 16154-16161.
MLA	Zhang, Yuan,et al."Rare-Earth Metal-Based Nanosystems for Facilitating Neural Stem Cell Differentiation into Neurons and Enhancing Axonal Stability".ACS APPLIED NANO MATERIALS 7.14(2024):16154-16161.