Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study

doi:10.1007/s00277-024-05875-w

科研成果详情

题名	Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study
作者	Jin, Yue 1; Zhao, Peng 1; Zhang, Yuan-Yuan 1; Ye, Yi-Shan 2; Zhou, Fang 3; Wan, Ding-Ming 4; Chen, Yi5; Zhou, Jian 6,7; Li, Xin 8; Wang, Yan 9,10; Liu, Yue 3; Bian, Zhi-Lei 4; Yang, Kai-Qian5; Li, Zhen 6,7; Zhang, Jian 8; Xu, Wen-Wei 9,10; Zhou, Jian-Ying 1; An, Zhuo-Yu 1; Fu, Hai-Xia 1; Chen, Yu-Hong 1; Chen, Qi 1; Wu, Jin 1; Wang, Jing-Zhi 1; Mo, Xiao-Dong 1; Chen, Huan 1; Chen, Yao 1; Wang, Yu 1; Chang, Ying-Jun 1; Huang, He 2; Huang, Xiao-Jun 1; Zhang, Xiao-Hui 1
发表日期	2024-07-11
发表期刊	ANNALS OF HEMATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Allogeneic hematopoietic stem cell transplantation Membranous nephropathy Chronic graft-versus-host disease Quality of life
其他关键词	VERSUS-HOST-DISEASE ; CONSENSUS DEVELOPMENT PROJECT ; NEPHROTIC SYNDROME ; CHRONIC GRAFT ; RENAL PATHOLOGY ; THROMBOTIC MICROANGIOPATHY ; MARROW-TRANSPLANTATION ; DIAGNOSIS ; RITUXIMAB ; ANTIGEN
摘要	Membranous nephropathy (MN) is a rare complication that can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT). MN patients may develop nephrotic syndrome or even kidney failure, which greatly affects their quality of life and prognosis. However, current knowledge regarding MN after allo-HSCT is limited. Thus, a multicenter nested case-control study was conducted. Patients who had been diagnosed with MN after allo-HSCT were retrospectively identified at 8 HSCT centers. A total of 51 patients with MN after allo-HSCT were included. The median age of MN patients after allo-HSCT was 38 years, and the median duration from HSCT to MN was 18 months. The use of HLA-matched donors (P = 0.0102) and peripheral blood as the graft source (P = 0.0060) were identified as independent predisposing risk factors for the onset of MN after allo-HSCT. Compared to those in the control group, the incidence of extensive chronic graft-versus-host disease was greater in the MN patients (P = 0.0002). A total of 31 patients developed nephrotic syndrome. Patients receiving combination treatments of corticosteroids and immunosuppressants appeared to have better outcomes. In conclusion, MN is a rare but occasionally severe complication following HSCT and may require active treatment.
资助项目	National Key Research and Development Program of China [2021YFC2500304]; Key Program of National Natural Science Foundation of China [82230004]; National Natural Science of Foundation of China [81970113]; Capital Health Research and Development of Special [2022-1-4082]
出版者	SPRINGER
ISSN	0939-5555
EISSN	1432-0584
卷号	103 期号:10 页码:4261-4270
DOI	10.1007/s00277-024-05875-w
页数	10
WOS类目	Hematology
WOS研究方向	Hematology
WOS记录号	WOS:001270595100001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38990296
SCOPUSEID	2-s2.0-85198046058
通讯作者地址	[Zhang, Xiao-Hui]Peking Univ, Peking Univ Peoples Hosp, Natl Clin Res Ctr Hematol Dis,Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplantat, Beijing, Peoples R China.
Scopus学科分类	Hematology
SCOPUS_ID	SCOPUS_ID:85198046058
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216681
专题	附属第一医院_血液内科
通讯作者	Zhang, Xiao-Hui
作者单位	1.Peking Univ, Peking Univ Peoples Hosp, Natl Clin Res Ctr Hematol Dis,Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplantat, Beijing, Peoples R China; 2.Zhejiang Univ, Affiliated Hosp 1, Dept Hematol, Sch Med, Hangzhou, Peoples R China; 3.Hosp Peoples Liberat Army, Dept Hematol, Jinan, Peoples R China; 4.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Hematol, Wenzhou, Peoples R China; 6.Zhengzhou Univ, Affiliated Canc Hosp, Dept Hematol, Zhengzhou, Henan, Peoples R China; 7.Henan Canc Hosp, Zhengzhou, Henan, Peoples R China; 8.Cent South Univ, Xiangya Hosp 3, Dept Hematol, Changsha, Peoples R China; 9.Shandong First Med Univ, Affiliated Hosp 1, Hematol Dept, Jinan, Peoples R China; 10.Shandong Prov Qianfoshan Hosp, Jinan, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yue,Zhao, Peng,Zhang, Yuan-Yuan,et al. Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study[J]. ANNALS OF HEMATOLOGY,2024,103(10):4261-4270.
APA	Jin, Yue., Zhao, Peng., Zhang, Yuan-Yuan., Ye, Yi-Shan., Zhou, Fang., ... & Zhang, Xiao-Hui. (2024). Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study. ANNALS OF HEMATOLOGY, 103(10), 4261-4270.
MLA	Jin, Yue,et al."Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study".ANNALS OF HEMATOLOGY 103.10(2024):4261-4270.