Clinical characteristics and prognosis analysis in septic patients with a high level of serum procalcitonin

doi:10.26914/c.cnkihy.2019.103052

科研成果详情

题名	Clinical characteristics and prognosis analysis in septic patients with a high level of serum procalcitonin
作者	Pan, Chuli 1,2; Zhou, Feifei 2,3; Lin, Xiuhui2,4; Wang, Dongying 2; Xuan, Nanxia 2; Tian, Baoping 2; Tu, Junwei 1; Cui, Wei 2; Zhang, Gensheng 2
发表日期	2021-01
会议录名称	BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 影响因子和分区
语种	英语
原始文献类型	Meeting Abstract
关键词	High level of serum PCT (> 100 mu g/L) Sepsis Clinical characteristics Prognostic factors
摘要	Background:Although the application of serum procalcitonin(PCT) in guiding the diagnosis and treatment of sepsis becomes more and more widely,its significance in a subgroup of septic patients with a high level of serum PCT(>100μg/L) remains largely unknown.Herein,we investigated the clinical characteristics and prognosis of such patients.Methods:A retrospective study for septic patients with a high level of serum PCT within 48 hours of hospitalization was conducted in our hospital from February 2013 to December 2016.Clinical characteristics including the demographics,main laboratory examinations and outcomes were extracted from the medical records.These patients were divided into survivors and non-survivors based on 28-day outcome.The differences of these variables were compared between groups of survivors and non-survivors.A multi-factorial logistic regression analysis was used for the evaluation of independent risk factors of mortality.Results:149 cases of such septic patients were included.There were 98 males and 51 females with an average age of 63(52,77) years.98(65.8%) patients were treated in intensive care unit(ICU),and 51(34.2%) patients were treated in general ward.The total mortality rate was 32.2%(48/149).The median acute physiology and chronic health evaluation II(APACHE II) score was 15(11,19),and the median sequential organ failure assessment(SOFA) score was 10(7,14).The APACHE II [20(18,27) vs.14(10,16),P<0.001]and SOFA scores [14(12,18) vs.8(6,11),P<0.001],and the incidence of complications including multiple organ dysfunction syndrome(MODS)(87.5% vs.37.6%,P<0.001),septic shock(100% vs.60.4%,P<0.001) and respiratory failure(72.9% vs.38.6%,P<0.001) were significantly higher in non-survivors than in survivors.In addition,some laboratory indexes including liver dysfunction,coagulation dysfunction,levels of myocardial enzymes and lactic acid were higher in non-survivors than in survivors(all P<0.05),whereas the platelet(PLT) count was significantly lower [72.0(20.8,123.0) vs.101.0(63.5,141.0),P=0.003] in non-survivors.The multi-factorial logistic regression analysis showed that high APACHE II scores [odds ratio(OR) 1.444,95% confidence interval(95%CI) 1.158-1.800,P=0.001] and the incidence of MODS(OR 26.040,95%CI 2.952-229.738,P=0.003) were independent predictors of mortality.Conclusions:The majority of septic patients with a high level of serum PCT(>100μg/L) were complicated with MODS,especially respiratory and circulatory dysfunction.Some laboratory indexes including PLT count,lactic acid,liver function,coagulation indexes and cardiac enzymes were correlated with the prognosis of such patients.High APACHE II scores and the incidence of MODS were independent predictors of poor prognosis in these septic patients with a high level of serum PCT.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570017]; Medical and Health Research Program of Zhejiang Province [2017KY371]
出版者	WILEY
出版地	HOBOKEN
ISSN	1742-7835
EISSN	1742-7843
卷号	128
页码	70-70
DOI	10.26914/c.cnkihy.2019.103052
页数	1
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000614873400125
收录类别	SCIE ; CNKI
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/21594
专题	附属第二医院_呼吸内科
作者单位	1.Jinhua Municipal Cent Hosp, Dept Resp Med, Jinhua, Zhejiang, Peoples R China; 2.Zhejiang Univ, Affiliated Hosp 2, Dept Crit Care Med, Sch Med, Hangzhou, Peoples R China; 3.Ningbo City Med Treatment Ctr Lihuili Hosp, Dept Crit Care Med, Ningbo, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 2, Dept Resp Med, Wenzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Pan, Chuli,Zhou, Feifei,Lin, Xiuhui,et al. Clinical characteristics and prognosis analysis in septic patients with a high level of serum procalcitonin[C]. HOBOKEN:WILEY,2021:70-70.